Zhongguo shiyan zhenduanxue, 2017 子宫内膜癌为女性常见恶性肿瘤之一,发病率仅次于宫颈癌,占生殖道恶性肿瘤20%-30%[1],其病因尚未完全明确。有研究认为子宫内膜癌与雌激素水平、内膜增生及遗传等因素相关[2]。子宫内膜癌早期诊断、早期治疗可取得良好疗效,其5年生存率可达70%[3]。溶血磷脂酸（LPA）为血小板、成纤维细胞、癌细胞等分泌的一种多功能的"磷脂信使",近年研究显示其作为肿瘤标志物有广阔的临床应用前景。本文回顾性分析2012年 ...
刘曼
doaj +1 more source
Mechanism of METTL14-mediated ERα m6A regulation of endometrial cancer metastasis [PDF]
, 2023 Background and purpose: Aberrant N6-methyladenosine (m6A) modification caused by dysregulation of methyltransferase-like factor 14 (METTL14) plays an important role in the progression of various cancers, and it is unclear whether it is involved in the ...
ZHAO Manying, WU Dongyue, DU Ruiting, YIN Lu, LUO Yulu
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Study on the Mediating Effect of Intimate Relationship between Dyadic Coping and Quality of Life in Gynecological Cancer Patients' Couples [PDF]
, 2022 BackgroundDyadic coping are associated with quality of life in gynecologic cancer patients, but the mechanism path of action is still unclear.ObjectiveTo explore the mechanism of intimate relationship between dyadic coping and quality of life in ...
YE Huihui, GE Lina, ZANG Shuang, HU Shuang
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, 2017 作为2型糖尿病的一线用药—二甲双胍,其作用被不断地挖掘,近年来科学家们发现二甲双胍不仅改善胰岛素抵抗(IR),还具有抗癌、抗炎、抗血栓形成、抗衰老等功效;其治疗的适应症不再局限于糖尿病,在肿瘤、甲状腺疾病、哮喘、心血管疾病、神经退行性病等领域上也开辟了新的疆土;现就关于二甲双胍对肿瘤、甲状腺疾病 ...
杨叔禹, 苏伟娟, 苏美梅
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The Inhibitory Effect of GSNO to Endometrial Cancer and Preliminary Study of the Mechanisms [PDF]
, 2017 目的：近年来子宫内膜癌发病率不断上升，严重影响女性健康，目前子宫内膜癌治疗手段仍以传统的手术治疗为主，辅以放疗、化疗、内分泌治疗等，毒副作用大，对患者的生活质量及恢复造成不良影响。分子靶向治疗药物具有特异性强，毒副作用小等优势，成为目前肿瘤治疗界的研究热点。S-亚硝基谷胱甘肽（GSNO）已被证实对多种恶性肿瘤有治疗作用。本课题拟通过体内外实验，探究GSNO对子宫内膜癌细胞生长的抑制作用，并对其可能的作用机制进行初步探讨，为子宫内膜癌的分子靶向治疗提供新的思路。 方法 ...
李清
core
Study on the tumor suppress mechanisms of ARID1A in hepatocellular carcinoma [PDF]
, 2015 肝细胞癌（Hepatocellularcarcinoma，HCC）（简称肝癌）是世界上，特别是中国，发病率最高的恶性肿瘤之一。据世界卫生组织估计，肝癌是世界上癌症相关死亡的第二大原因。应对肝癌，传统有效治疗手段就是肝癌切除或者肝移植。近些年射频消融和新兴化疗药物也被用来治疗肝癌。尽管对肝癌的诊断与治疗策略有长足的改进，但是肝癌晚期的病人还是容易发展转移，而且由于肝癌切除术后高频复发，病人的预后生存期才不足数月。鉴于现有的诊疗手段不足以彻底根治肝癌 ...
何飞
core
Progress in Epidemiological Research on Relationship Between Duration of Type 2 Diabetes and Risk of Malignant Tumors of Female Reproductive System [PDF]
The relationship between the duration of type 2 diabetes mellitus (T2DM) and the risk of female reproductive malignancies is complex and multifaceted. Large population cohort studies revealed a negative association between the duration of T2DM and the ...
Peiwen LU +6 more
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Preclinical studies of CD103 molecular imaging to guide cancer immunotherapy [PDF]
, 2023 In summary, this study aims to lay the foundation for the clinical application of CD103 immune PET by developing various tracer types and conducting preliminary in vivo exploration using animal models. It is our hope that these humanized CD103 immune PET
Fan, Xiaoyu
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Effects of olive oil on osteoporosis after artificial menopause [PDF]
, 2015 随着妇科恶性肿瘤发病率的逐年上升及越趋年轻化，给社会和家庭带来了巨大的经济和精神负担。妇科恶性肿瘤主要以手术为主，并辅以放化疗。随着手术切除双侧卵巢及放化疗对卵巢损害的发生，将会导致雌激素急剧下降，从而增加骨质疏松症的发病率。目前激素替代疗法（hormonereplacementtherapy，HRT）广泛用于防治人工绝经后骨质疏松症，但是有临床大样本研究表明，HRT虽然能够减缓绝经后骨质疏松症的发生，但也增加了心血管疾病、乳腺癌、中风、糖尿病、宫颈癌、子宫内膜癌、卵巢癌等的发病率 ...
刘慧兰
core
A case analysis of primary fallopian tube carcinoma [PDF]
目的 探讨原发性输卵管癌的诊断，减少漏诊率的发生。方法 复习1例原发性输卵管癌的临床资料，分析原发性输卵管癌漏诊的原因及在诊断中容易忽视的几个环节。结果 根据患者诊刮病理提示为子宫内膜中分化腺癌，未考虑输卵管癌的可能，术中忽视输卵管的改变，未送快速冰冻切片检查，因此导致漏诊。结论 输卵管癌发病率较低，患者症状表现不典型，盆腔未发现包块，医生警惕性不够，根据诊刮病理结果形成了先入为主的观念，以致术中亦忽略了剖视输卵管。因此对于考虑子宫内膜癌的患者，应警惕输卵管癌的可能。Objective: To ...
Jiang, Ling
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