BRD4在宫颈癌中的表达及其抑制剂 JQ1对细胞增殖、迁移的影响
目的 探究溴结构域蛋白4(Bromodomain-containing protein 4,BRD4)在宫颈癌中的表达及其抑制剂JQ1对细胞增殖和迁移的影响。方法 收集51例宫颈癌患者及51例子宫良性病变患者的宫颈组织标本,应用免疫组织化学染色方法检测正常宫颈组织及宫颈癌组织BRD4的表达情况,并应用统计学方法分析BRD4表达与宫颈癌患者的FIGO分期、浸润间质深度、分化程度、盆腔淋巴结转移、淋巴脉管间隙浸润是否具有相关性;体外培养宫颈癌Hela和SiHa细胞,CCK ...
何居洋, 张印霞, 韩丽英
doaj
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