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Journal of Diabetes, Volume 14, Issue 4, Page 236-246, April 2022., 2022 Highlights Diabetic kidney disease is a progressive disease with the pathology of glomerular damage and loss of podocytes. Sodium glucose cotransporter 2 inhibitors (SGLT2i) can be expected to decrease the amount of podocyte excretion. Male patients receiving SGLT2i have better diabetic kidney disease‐related parameters and podocyturia levels. Abstract
Emre Durcan +13 more
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Journal of Diabetes, Volume 14, Issue 1, Page 15-25, January 2022., 2022 Highlights Approximately 63.6% of diabetes patients with an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 have normal albuminuria. The factors related to normoalbuminuria and eGFR < 60 mL/min/1.73 m2 were male sex, older age, higher triglyceride levels, lower extremity arterial disease, and a longer duration of diabetes. Compared with
Xiaomeng Jia +8 more
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Developmental Medicine &Child Neurology, Volume 63, Issue 8, Page e1-e4, August 2021., 2021 目的 探討全基因體定序 (WGS) 對兒童神經疾病的診斷率及治療影響。 方法 從 2016 年 1 月至 2019 年 12 月, 使用全基因體定序對疑似患有遺傳性神經疾病的兒科病人進行評估。符合條件的病人依其臨床表現型分為四組: 神經發展障礙病人、癲癇病人、神經肌肉疾病病人及運動障礙病人。我們描述全基因體定序的診斷率及經全基因體定序確診後對病人治療的影響。 結果 共有 214 例病人 (男性 128 例, 女性 86 例) 接受了全基因體定序檢測, 病人平均 (SD) 發病年齡為 13.8 (27.6) 個月, 範圍為 1 天至 15 年 5 個月, 接受全基因體定序檢測的平均 (SD) 年齡為 71.7 (58.9) 個月, 範圍從 8 天到 18 歲。 43.9 ...
李 秀芬, 遲景 上, 蔡 啟仁
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早期糖尿病肾病血清β2-微球蛋白、尿微量白蛋白测定的临床意义 [PDF]
, 2018 目的:回顾性分析β2-微球蛋白、尿微量白蛋白表达及诊断情况与糖尿病肾病病情发展情况相关性,从而明确二者在早期糖尿病肾病中的诊断价值。方法:选取2016年5月-2017年10月在笔者所在医院治疗的糖尿病患者100例,将该100例患者按临床诊断分为临床无肾病组、早期肾病组、临床肾病组。选取40例来笔者所在医院做健康体检的正常个体作为对照组。对糖尿病肾病患者及正常个体血清β2-微球蛋白、尿微量白蛋白进行检测并进行对比分析。结果:血液检测中,对照组血清β2-微球蛋白水平为（2.24±1.08）mg/L ...
廖蕴惠, 赵军
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Journal of Diabetes, Volume 12, Issue 5, Page 406-416, May 2020., 2020 Highlights In patients with hypertension and diabetes, early detection and intervention of insulin resistance and related risk factors in patients with normal BMI may reduce the occurrence of urinary microalbumin and delay the progression of CKD. Abstract Background The relationship between albuminuria and insulin resistance (IR) has not been clarified
Shi Gu +4 more
wiley +1 more source
Is the Change of Cytokines Related to Renal Damage in Children with IgA Vasculitis？ [PDF]
, 2022 BackgroundThe long-term prognosis of IgA vasculitis (IgAV) depends on thedegreeof renal damage. Studies on the pathogenesis of renal injury in IgAV have found that cytokines play an important role in mediating and driving the process of renal damage ...
WANG Mengdi, DU Yue
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Journal of Diabetes, Volume 12, Issue 3, Page 224-236, March 2020., 2020 Highlights Diabetic conditions induce compositional dysbiosis of the gut microbiota and impair gut barrier integrity. Diabetic conditions markedly downregulate the abundance of Faecalibacterium prausnitzii in the gut. Under diabetic conditions, microbial anti‐inflammatory molecules from Faecalibacterium prausnitzii restore the gut barrier and ZO‐1 ...
Jihao Xu +7 more
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沙格列汀联合小剂量厄贝沙坦对30例早期糖尿病肾病患者预后的影响 [PDF]
, 2018 目的观察沙格列汀联合小剂量厄贝沙坦对早期糖尿病肾病患者预后的影响。方法 2017年6月—2018年3月选取该院60例早期糖尿病肾病患者为研究对象,随机分为治疗组(30例)与对照组(30例),对照组予以常规治疗+厄贝沙坦口服治疗,治疗组在对照组的基础上予以沙格列汀口服治疗,两组疗程均为3个月。检测两组患者治疗前后空腹血糖(GLU)、血清尿素氮水平、血清肌酐浓度以及瘤坏死因子-α(TNF-α)、超敏C-反应蛋白(hs-CRP)、白细胞介素-6(IL-6)炎性因子水平 ...
肖国鸣
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Identification of pathogenic mutations for a Wolfram syndrome pedigree by whole exome sequencing and analysis of its clinical characteristics [PDF]
, 2023 Objective·To identify the causative gene and mutations and describe the clinical traits in a Chinese diabetes pedigree suspected of Wolfram syndrome.Methods·A total of 12 subjects from one family were included.
CHEN Xianghui +9 more
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The Efficacy of Whole Course Management in Patients with Schizophrenia [PDF]
, 2022 BackgroundSchizophrenia is a common mental disease with high rates of recurrence and disability. The therapeutic effects of antipsychotic drugs monotherapy are insufficient on improving patients' ability to daily life and social functioning, with ...
ZULAYETI•Tuerxun, ZHANG Guiqing, YAO Yongkun, LU Keke
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