Results 11 to 20 of about 7,139 (162)
Highlights In the first trimester, the plasma mitochondrial DNA (mtDNA) was higher in women who developed gestational diabetes mellitus (GDM) than in women who did not develop GDM during their pregnancy. The increased levels of plasma mtDNA were independent of age and fasting plasma glucose levels in the first trimester.
Dushyant Kumar Sahu, Jessy Abraham
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Highlights Few studies have investigated the association of large‐scale biomarkers and pulse wave velocity (PWV) among diabetic patients. This study investigates the relationships of serum laboratory tests with PWV and explored the associations between PWV and all‐cause mortality among diabetic patients.
Yong‐Qi Liang +9 more
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Highlights Nattokinase rescued endothelial dysfunction and pericyte loss in the diabetic retina. Nattokinase attenuated diabetes‐induced retinal inflammation and neurodegeneration. High mobility group box 1 signaling was involved in nattokinase‐mediated retinal protection.
Zijing Huang +11 more
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Highlights The gender‐specific role of sphingolipids in obesity‐related metabolic dysfunctions is unclear. The aim of this study is to identify ceramide species by liquid chromatography‐mass spectrometry that accumulate in central fat in relation to status of diabetes and gender for subjects with a body mass index ≥40 kg/m2 or > 35 kg/m2 with ...
Michelle Brusatori +7 more
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Abstract Objective A trial comparing prenatal with postnatal open spina bifida (OSB) repair established that prenatal surgery was associated with better postnatal outcome. However, in the trial, fetal surgery was carried out through hysterotomy. Minimally invasive approaches are being developed to mitigate the risks of open maternal–fetal surgery.
D. A. Lapa +9 more
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目的 探討全基因體定序 (WGS) 對兒童神經疾病的診斷率及治療影響。 方法 從 2016 年 1 月至 2019 年 12 月, 使用全基因體定序對疑似患有遺傳性神經疾病的兒科病人進行評估。符合條件的病人依其臨床表現型分為四組: 神經發展障礙病人、癲癇病人、神經肌肉疾病病人及運動障礙病人。我們描述全基因體定序的診斷率及經全基因體定序確診後對病人治療的影響。 結果 共有 214 例病人 (男性 128 例, 女性 86 例) 接受了全基因體定序檢測, 病人平均 (SD) 發病年齡為 13.8 (27.6) 個月, 範圍為 1 天至 15 年 5 個月, 接受全基因體定序檢測的平均 (SD) 年齡為 71.7 (58.9) 個月, 範圍從 8 天到 18 歲。 43.9 ...
李 秀芬, 遲景 上, 蔡 啟仁
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Background – Oclacitinib is an effective systemic therapy for dogs with atopic dermatitis (AD). Few studies have evaluated concurrent topical treatment with oclacitinib in dogs. Objectives – To evaluate the efficacy and safety of combination therapy of oclacitinib and 0.0584% hydrocortisone aceponate (HCA) spray in dogs with AD.
Junko Takahashi +9 more
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Background Bacterial densities likely fluctuate during infection and may exceed the bacterial density used in susceptibility testing. As such, investigation of bacterial killing by antibiotics over a range of varying bacterial densities may provide important differences between compounds and could impact drug selection for therapy.
Joseph M. Blondeau, Shantelle D. Fitch
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Objective. To verify and evaluate the value of CD40 as a noninvasive biomarker of cisplatin‐resistant bladder cancer, we studied the expression of CD40 and the correlation between nucleophosmin (NPM1) and CD40 in cisplatin‐resistant bladder cancer. Methods.
Chenshuo Luo +5 more
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