本研究探讨抗原刺激粘膜免疫及封闭网状内皮系统与IgA于肾小球系膜沉积的关系实验用8-10周BALB/c雌性小鼠60只,分别口服饮食抗原(麦胶蛋白和牛-γ球蛋白),并于实验开始后前3周用或不用印度墨水尾静脉注射。实验第14周后杀检,作肾组织病理检查。结果表明:单纯口服饮食抗原组,免疫荧光显示,肾小球系膜IgA阳性率为(58%~67%);口服抗原加网状内皮系统封闭组,则为(73%~83%),IgA荧光稍强于IgG。光镜和电镜结果均提示肾小球系膜区增生;网状内皮系统功能在14周明显减弱。24h尿蛋白无异常 ...
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