Results 11 to 20 of about 353,846 (156)
目的: 有报道糖皮质激素( GCs)亦可加重肾脏病蛋白尿。本课题旨在探讨 GCs 是否加重激素不敏感肾病综合征 ( NS)蛋白尿及其机制, 以指导临床合理使用 GCs。方法: 19 例对激素不敏感的 NS 患儿予泼尼松每日 1. 5~ 2 mg/kg 隔日早上 08∶ 00顿服。同时检测激素日和无激素日的尿蛋白及其成分、白蛋白和免疫球蛋白 G 及肌酐的清除率、肾有效血浆流量 ( ERPF)、尿前列腺素等并进行比较。结果: 与无激素日比较, 激素日尿蛋白明显增加( 2. 4 g±0. 5 g vs 1.
莫 樱 陈述枚
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摘 要 研究37只病程1~ 6个月糖尿病及29只同龄对照大鼠血浆及肾组织肾素活性、ATⅡ 含量、肾组 织血管紧张素原基因m RN A表达水平等改变。发现仅在病程3个月时糖尿病鼠血浆ATⅡ 及肾组织血管紧张 素原mRN A表达水平升高,病程1~ 6个月糖尿病鼠肾组织ATⅡ 含量均升高。结果显示: 糖尿病鼠肾组织与血 浆肾素血管紧张素系统活性改变呈不平行现象; 肾组织肾素-血管紧张素系统活性增强可能是糖尿病肾病形成 及发展的重要因素之一。
杨荣泽 严 励 傅祖植 钟光恕 严 棠
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Enthalpic interactions of glycine in aqueous urea solutions at 298.15K(甘氨酸在尿素水溶液中的焓对相互作用)
用LKB-2277精密微热量计测定了298.15K时甘氨酸在尿素水溶液(尿素的质量分数为0.05~0.40,以0.05递增)中的稀释焓,并根据McMillan-Mayer过量焓理论关联得到焓对作用系数.结果表明,甘氨酸的焓对作用系数与溶剂结构密切相关,其数值随尿素浓度的增大而增大,且在尿素高浓度区由负变为正.
SHAOShuang(邵爽) +2 more
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纤维素经过活化、再生后可以溶解在氢氧化钠/尿素体系中。本文研究了乙二胺活化对细菌纤维素结晶度的影响规律,得到最佳活化条件;然后将活化后的细菌纤维素在LiCl/DMAc体系中溶解再生,得到再生细菌纤维素。最后,使用氢氧化钠/尿素溶液作为再生细菌纤维素的复合溶剂,得到的细菌纤维素的水溶液。通过红外光谱、X射线衍射仪、热重分析仪等分析了细菌纤维素不同处理阶段得到产物的性能。溶解与再生并没有发生化学变化,纤维素的结构基本保持不变,但结晶度有所降低 ...
王璨 +5 more
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【目的】 探讨胰岛素治疗改善2型糖尿病大鼠肝脏中色素上皮衍生因子(PEDF)的表达及其内在机制。【方法】 8周龄雄性Spraque-Dawley大鼠高脂喂养联合小剂量链脲佐菌素诱导糖尿病模型(12只),按随机数字表法分3组为:糖尿病模型组(DM,6只)胰岛素治疗组(INS,6只);另设正常对照组(N,6只)通过Western blotting法检测大鼠肝脏PEDF基质金属蛋白酶(MMP2)和肿瘤坏死因子-α(TNF-α)的蛋白表达【结果】 胰岛素治疗后降低了糖尿病大鼠空腹血糖及血清甘油三酯的含量 ...
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Abstract Incipient diagnosis and noninvasive forecasts using urinary biomarkers are important for preventing diabetic kidney disease (DKD) progression, but they are also controversial. Previous studies have shown a potential relationship between urinary tubular biomarkers (UTBs) and traditional Chinese medicine (TCM) syndrome in patients with DKD. Thus,
Wei Wu +11 more
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Highlights The Blood Pressure Control Target in Diabetes (BPROAD) study is a multicenter, randomized controlled trial conducted in mainland China to test the hypothesis of whether intensive blood pressure (BP) management (systolic BP <120 mm Hg) has additional benefits over standard BP management (systolic BP <140 mm Hg) over a follow‐up period of up ...
The BPROAD Study Group +18 more
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Highlights The optimal blood pressure (BP) target in patients with type 2 diabetes mellitus (T2DM) for the management of cognitive decline remains unknown. The Blood Pressure Control Target in Diabetes (BPROAD) Cognitive Study was designed to determine whether intensive BP treatment (systolic BP <120 mm Hg) reduces risk of dementia and mild cognitive ...
The BPROAD Study Group +18 more
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Highlights We identified that CGM can increase motivation for self‐management and confidence in treatments. A supportive treating team may help to reduce the practical and psychological burden in patients with type 1 and type 2 diabetes. Abstract Aims Blood glucose control is central to the management of diabetes, and continuous glucose monitoring (CGM)
Patrizia Natale +10 more
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Highlights Weight gain with insulin therapy in the early period may be negatively related to the occurrence and duration of remission by altering insulin sensitivity. Interventions to prevent rapid weight gain and conserve insulin sensitivity in the early stages of type 1 diabetes mellitus may be beneficial for the development and maintenance of ...
Dicle Canoruc Emet +9 more
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