Results 21 to 30 of about 3,672 (167)
Updated insights into the molecular pathogenesis of canine atopic dermatitis
Veterinary Dermatology, Volume 36, Issue 4, Page 375-384, August 2025.Abstract Atopic dermatitis (AD) is a common and chronic inflammatory skin disease with frequent relapses. The genomics revolution has greatly contributed and revolutionised our knowledge of human AD; understanding the molecular skin fingerprint of AD and associated pathogenic immune pathways has led to preclinical assessments of several novel ...
Frane Banovic
wiley +1 more source
The Oncologist, Volume 24, Issue 11, Page e1044-e1054, November 2019., 2019 Abstract Background The molecular phenotype of circulating tumor cells (CTCs) was associated with clinical outcome of patients with breast cancer. CTCs isolated from patients with metastatic breast cancer (MBC) display a unique microRNA (miRNA) expression profile.
Weige Tan +11 more
wiley +1 more source
Revisions to the Classification, Nomenclature, and Diversity of Eukaryotes
Journal of Eukaryotic Microbiology, Volume 66, Issue 1, Page 4-119, January/February 2019., 2019 Abstract This revision of the classification of eukaryotes follows that of Adl et al., 2012 [J. Euk. Microbiol. 59(5)] and retains an emphasis on protists. Changes since have improved the resolution of many nodes in phylogenetic analyses. For some clades even families are being clearly resolved.
Sina M. Adl +46 more
wiley +1 more source
Sfmbt2 10th intron hosted microRNA-669e-5p/3p promote cellular apoptosis by targeting anti-apoptotic gene Bcl2 [PDF]
, 2012 细胞凋亡是一个主动的由基因决定的自动结束生命的过程，对有机体的正常运行和体内稳态有重要作用。细胞凋亡一旦受到抑制，很可能导致肿瘤发生。然而，肿瘤发生发展过程中细胞凋亡调控的有关机制还不完全清楚。microRNAs（miRNAs）是一类非编码的小分子RNA，它们具有调节基因表达活性的功能，在细胞的各个进程（如细胞凋亡，分化和发育中）发挥着重要的作用。在肿瘤中miRNAs有可能通过调节与凋亡相关基因的表达，参与肿瘤细胞凋亡的调控。 miR-669e-5p和miR-669e ...
王涛
core
Methods in Ecology and Evolution, Volume 15, Issue 8, Page 1408-1421, August 2024.Abstract Environmental DNA (eDNA) monitoring of species distribution has become a critical tool in ecology, conservation biology and fisheries for identifying the presence and distribution of diverse organisms, including important, threatened and invasive species.
Jiwei Yang +4 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2010 目的探讨膀胱癌中微小RNA-21和肿瘤抑素表达与临床病理特征之间的关系。方法采用SABC法对98例膀胱癌患者分别进行微小RNA-21和肿瘤抑素的免疫组化染色,其与肿瘤临床分期和细胞分级间的关系及微小RNA-21和肿瘤抑素在瘤细胞中的共表达情况。结果膀胱癌患者中微小RNA-21和肿瘤抑素的阳性表达率分别是69.4%和43.9%。与浅表性和分化较好的膀胱癌相比,侵袭性和分化差的癌细胞中微小RNA-21表达上调明显,而肿瘤抑素表达则显著下调,组间比较 ...
李然伟 +5 more
doaj
A study about the impact of overpression of Oct4 and Sox2 gene on gastric cancer cell biology and oncology characteristics [PDF]
, 2015 目的：通过构建过表达干细胞因子Oct4和Sox2的胃癌SGC7901细胞株，研究过表达干细胞因子Oct4和Sox2对SGC7901胃癌细胞干细胞特性、肿瘤学特性、及生物学特性的影响，并探讨Oct4及Sox2在肿瘤细胞中的作用机制。 方法：1.构建携带Sox2基因的重组质粒，慢病毒载体感染SGC7901-OCT4细胞株得到SGC7901-OCT4-SOX2稳转细胞株。2.利用荧光定量PCR、western–bloting检测过表达Oct4及Sox2的胃癌SGC7901细胞中胃癌干细胞标志基因表达情况。3 ...
李文鹏
core
Zhongguo shiyan zhenduanxue, 2018 微小RNA（miRNAs）是一类内源性的高度保守的非编码蛋白质的单链小分子RNA。它们通过与靶基因结合,在转录后水平导致靶mRNA的翻译抑制或降解,调节靶基因的表达[1]。微小RNA-92（miR-92）是近年来发现的一种新型miRNA ...
郭凤军, 邹颖刚, 李丹, 田静岩
doaj