Results 11 to 20 of about 8,549 (158)
Journal of Diabetes, Volume 15, Issue 12, Page 1081-1094, December 2023., 2023 Highlights Glucagon receptor (GCGR) monoclonal antibody (mAb) improves cardiac function and attenuates microvascular damage in db/db mice. GCGR mAb ameliorates the oxidative stress of cardiac microvascular endothelial cells in diabetic mice. GCGR mAb counteracts the diabetes‐induced upregulation of carnitine palmitoyltransferase 1B, optic atrophy type ...
Peng Wang +6 more
wiley +1 more source
Journal of Diabetes, Volume 15, Issue 4, Page 313-324, April 2023., 2023 Highlights Different microvascular phenotypes were detected by noninvasive optical coherence tomography angiography (OCTA) in metabolically healthy obesity and metabolic syndrome patients. Baseline blood pressure and insulin status may be key determinants for vascular benefit from bariatric surgery.
Yaying Chen +11 more
wiley +1 more source
Type 1 diabetes management: Room for improvement 1型糖尿病管理的改进空间
Journal of Diabetes, Volume 15, Issue 3, Page 255-263, March 2023., 2023 Highlights Achievement of glycemic, lipid, and blood pressure targets are suboptimal. Individuals with type 1 diabetes and cardiovascular disease (CVD) have more difficulty reaching treatment targets than individuals with diabetes without CVD. More consideration may be required for individuals with a previous cardiovascular event and type 1 diabetes ...
Rita D. M. Varkevisser +6 more
wiley +1 more source
Journal of Diabetes, Volume 14, Issue 6, Page 365-376, June 2022., 2022 HighlightsAssociation of lipid variability with diabetic microvascular complications. Abstract Background Greater lipid variability may cause adverse health events among diabetic patients. We aimed to examine the effect of lipid variability on the risk of diabetic microvascular outcomes among type 2 diabetes mellitus patients.
Daniel Nyarko Hukportie +6 more
wiley +1 more source
Preliminary Studies of Neuropilin-1 Expression on HCC and Inhibitive Effect of Anti-NRP-1 Monoclonal Antibody on HCC Growth [PDF]
, 2015 摘要 研究背景和目的 肝癌是世界上最常见的恶性肿瘤之一，男性与女性中肝癌诊断率分别为世界第五和第七，男性及女性肝癌相关死亡率在癌症相关死亡中分别居第二和第六。肝细胞癌占所有肝癌的70%-85%，其诊断和治疗取决于多方面因素——肿瘤的大小，范围，全身和肝功能情况。早期确诊的肝癌患者，才有可能接受肝脏切除或移植等治疗。然而仅有10%-30%的肝细胞癌患者适合根治性治疗，大多数肝细胞癌患者，确诊时已经处于中晚期，无法行根治性治疗，且预后较差。而传统的介入治疗、放化疗存在抗肿瘤效果较差、副作用大等缺点 ...
张亚飞
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Zhongguo shiyan zhenduanxue, 2002 目的 采用以体视学原理为基础的微血管长度密度测量法 （MVLD法 ）检测肿瘤微血管 ,并和传统方法（MVD法 ）结果进行比较 ,分析其差异及意义。方法选取基底细胞癌标本 78例 ,分为侵袭型 （36 / 78）和非侵袭型 （42 /78）两组 ,经免疫组化实验标记vWF显示血管内皮细胞后 ,采用MVLD法和MVD法检测肿瘤灶内微血管的状态 ,并比较两法之间的差异及意义。结果 两法皆显示两型的瘤灶微血管密度状态有明显差异 （P
罗育武 +3 more
doaj
Effects of Recombinant Human Endostatin and Docetaxel on MMP and its Following Anti-neoplastic Effect under Different Administration Sequences [PDF]
, 2010 Background and objective The aim of this study is to observe the changes of MMP-2 and its regulators, and to investigate the mechanism of the two administration sequences of recombinant human endostatin (rh-endostatin) and docetaxel.
Jing YUAN, Kai LI
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Zhongguo shiyan zhenduanxue, 2006 目的应用小鼠肿瘤模型,通过血管内皮细胞生长因子表达肿瘤微血管密度,了解血管抑素抑制肿瘤血管新生。方法免疫组化测定血管内皮细胞生长因子,通过肿瘤微血管密度表达肿瘤血管生长的情况,探讨肿瘤血管新生发生的可能机制。结果血管内皮细胞生长因子在肿瘤中的表达较少,主要表达在内皮细胞中。结论血管内皮细胞生长因子可以表达肿瘤血管密度,证明血管抑素可以抑制肿瘤血管新生。
孙海侠, 范恩学, 李爱丽
doaj
Effect of multi-devascularization combined with Curcumin perfusion in the treatment of hepatic VX2 carcinoma in rabbit and on the residual carcinoma angiogenesis [PDF]
, 2015 目的：研究姜黄素和肝脏周围防粘连隔离膜包裹对经肝动脉、门静脉栓塞治疗VX2肝癌兔的肝功能和生存期的影响；碘化油栓塞肿瘤血管后的残癌组织内血管新生旺盛，本实验探讨姜黄素和肝周防粘连隔离膜包裹对栓塞后残癌组织血管新生的影响。 方法：40只新西兰大白兔随机分成4组，开腹接种法建立VX2肝癌模型。两周后开腹行肝动脉、门静脉置管术，其中B组、D组手术置管同时行肝周防粘连隔离膜包裹隔离术。手术一周后通过留置化疗泵给药，A组、B组：单纯碘化油栓塞剂，C组、D组：姜黄素和栓塞剂混合乳剂。即A组：肝动脉、门静脉置管 ...
徐政
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眼镜蛇毒因子抑制补体激活对脓毒症大鼠血清细胞因子的影响 [PDF]
, 2018 目的:观察眼镜蛇毒因子(cobra venom factor,CVF)对脓毒症大鼠外周血中肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)和白介素-10(IL-10)的影响。方法:选取清洁级雄性SD大鼠144只,按照随机数字表法将大鼠分为A组(假手术组)、B组(脓毒症组)、C组(CVF预处理组),各48只;各组按照标本采集点的不同又分为术后2、4、8、12、16、24 h六个时间点亚组,各8只。B、C组采用盲肠结扎穿孔术(CLP)制作脓毒症大鼠模型;C组大鼠在CLP术前静脉注射CVF,而A ...
康福新 +5 more
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