Results 61 to 70 of about 3,349 (118)

巨噬细胞及其外泌体在心脏疾病中的研究进展

Zhongshan Daxue xuebao. Yixue kexue ban
巨噬细胞作为心脏固有免疫系统的关键细胞，具有高度异质性和可塑性，在心脏生理和病理进程中发挥双重作用。近年，巨噬细胞源性外泌体作为细胞间通讯的重要介质，在心脏疾病中的调控机制及潜在治疗应用备受关注。本文系统总结心脏常驻巨噬细胞的起源、分布和功能，探讨M1和M2型巨噬细胞在心脏炎症反应和组织修复中的作用，以及巨噬细胞外泌体在心脏疾病中的调控机制和治疗应用前景。在心脏损伤急性阶段，M1型巨噬细胞通过分泌促炎细胞因子等引发炎症，清除细胞碎片，但过度激活会导致心肌细胞损伤和纤维化；恢复阶段，M2型巨噬细胞主导 ...
谭云科, 杨正飞
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[Extracellular matrix materials and tissue regeneration and repair]. [PDF]

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
Zhao L, Xie H.
europepmc   +1 more source

[Shihu Mixture alleviates diabetic cardiomyopathy in rats by Sirt3-mediated upregulation of myocardial mitochondrial mitophagy pathway]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Lin X, He Y, Shi H, Liu J, Hu H.
europepmc   +1 more source

[Construction of cardiac organoids derived from human induced pluripotent stem cells for cardiac disease modeling and drug evaluation]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Gong X, Fan Y, Luo K, Yan Y, Li Z.
europepmc   +1 more source

灭活链球菌诱导的实验性慢性风湿性心瓣膜炎

Zhongshan Daxue xuebao. Yixue kexue ban, 2010
【目的】 诱导慢性风湿性心瓣膜炎的动物模型,为风湿性心脏病的研究提供实验工具。【方法】 Lewis雌鼠24只,随机分为A、B、C三组,每组8只，抗原D为经40 g/L的多聚甲醛溶液灭活，超声处理，完全弗氏佐剂(CFA)乳化的A组链球菌(GAS),抗原E为经40 g/L的多聚甲醛溶液及超声处理，不加CFA的GAS，A B组皮下注射抗原D,每7 d一次,3次后改为注射抗原E、C组为对照组,同样方法注射CFA及生理盐水，12周后处死A组,24周后处死B、C组，行血清抗链球菌溶血素“O”(ASO ...
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[Aloe-emodin inhibits scar tissue fibrosis through thrombospondin-1-PI3k-Akt pathway]. [PDF]

Hua Xi Kou Qiang Yi Xue Za Zhi
Geng H, Zhang X, Zhou S, Li N, Liu J, Yuan X, Ning C, Zhang X, Huang W.   +8 more
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[Key role of biomechanical properties and material selection in rotator cuff repair]. [PDF]

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
Cai X, Zhou Y.
europepmc   +1 more source

[Research progress on cellular metabolic reprogramming in skin fibrosis]. [PDF]

Zhejiang Da Xue Xue Bao Yi Xue Ban
Qian S, Dai S, Guo C, Xu J.
europepmc   +1 more source

[Research progress on extracellular vesicles derived from platelet-rich plasma in tissue repair and regeneration]. [PDF]

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
Han J, Cheng B.
europepmc   +1 more source

诊断轻链型心脏淀粉样变的超声心动图新进展

Zhongguo shiyan zhenduanxue
轻链型心脏淀粉样变(Amyioid light-chain cardiac amyloidosis，AL-CA)是一种浸润性限制型心肌病，是由浆细胞异常增殖产生单克隆免疫球蛋白轻链，其错误折叠形成不可溶的淀粉样蛋白纤维沉积于心肌细胞间质和血管周围，导致心脏结构和功能的素乱。其临床表现无特异性，病程进展迅速，预后极差。因此，早期诊断并及时启动治疗意义重大。超声心动图作为诊断 AL-CA 的首选影像学手段，通过斑点追踪技术、压力-应变环分析、多参数评估、衍生参数及人工智能的辅助，为临床提供了更多敏感指标 ...
张赫展, 付启航, 张冬雪, 徐卉
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