Research Progress on Pathological Fibrosis of Sinoatrial Node [PDF]
, 2021 Human heart rhythm is mainly regulated and controlled by the sinoatrial node. Fibrosis plays an important regulating role in adjusting the structural and functional integrity of the sinoatrial node pacemaker complex.
WANG Wei, ZHANG Shi-lin, LIU Fang-fang, et al.
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酒精性心肌病合并心房颤动的临床特征及影响因素分析 [PDF]
, 2021 目的探讨酒精性心肌病（ACM）合并心房颤动（AF）的患者的临床特征，分析各特征与ACM患者发生AF的相关性。方法回顾性分析2013年1月至2020年4月期间于中山大学附属第三医院心血管内科住院的ACM患者42例及ACM合并AF（ACM-AF）患者17例为研究对象，收集患者的临床资料、实验室指标及超声心动图检查结果，比较其临床特征，并采用多因素Logistic回归分析研究ACM患者发生AF的相关影响因素。结果单因素分析显示，ACM-AF组与ACM组在年龄［（56.82±9.48）岁 vs.
刘可美 +4 more
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Zhongguo shiyan zhenduanxue, 2021 1临床资料患者女,66岁,于当地体检时发现双肺散在结节3天,为求进一步诊治来就诊。自述先天性心脏病史,具体不详。无外伤史及手术史。入院体格检查:体温36.5℃,脉搏76次/分,呼吸23次/分,血压131/74mmHg(1 mmHg=0.133kPa);心脏查体未见明显异常,听诊各瓣膜区心音正常,无额外心音及杂音,无心包摩擦音。心电图所见:窦性心律不齐;QRS电轴右偏+92°;不正常心图;右室肥厚;心肌劳损;未见异常Q波(图1)。超声心动图示:左房增大、前后径37.0mm,左室肥厚,厚度11.9 mm;
石柳 +5 more
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Interpretation of the 2015 guidelines on diagnosis and treatment of endogenous subclinical hyperthyroidism by the European Thyroid Association [PDF]
, 2017 亚临床甲状腺功能亢进症在临床中很常见,但对其危害及处理有很大的争议。欧洲甲状腺学会根据现有的临床证据,公布了内因性亚临床甲状腺功能亢进症诊治指南; 。指南强调,要确立持续性亚临床甲状腺功能亢进症的诊断,明确其病因,按照其进展为临床甲亢、发生不良心血管事件及骨质疏松风险进行危险分层,以指导临床; 处理。Endogenous subclinical hyperthyroidism (Endo SHyper) is a common form of; thyroid diseases.
刘超, 李学军, 肖方森
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Role of oxidative stress in trichloroethylene-induced toxicity [PDF]
, 2022 Trichloroethylene (TCE) is a common industrial organic solvent and environmental contaminant. People are exposed to TCE through occupational contact or environmental pollution, which leads to serious human health hazards.
Jinfeng ZHAO +4 more
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MicroRNA-99b-5p通过抑制成纤维细胞生长因子21表达促进心肌细胞肥大
Zhongshan Daxue xuebao. Yixue kexue ban, 2022 目的研究微小RNA microRNA-99b-5p（miR-99b-5p）对心肌细胞肥大表型的调节作用及机制。方法实时荧光定量PCR（RT-qPCR）检测人心肌组织（包括健康对照者、心力衰竭患者心肌组织）以及横向主动脉缩窄（TAC） 手术小鼠心肌中miR-99b-5p的表达水平。血管紧张素Ⅱ（AngⅡ）处理原代乳小鼠心肌细胞（NMVCs）后，利用鬼笔环肽染色呈现心肌细胞大小，RT-qPCR检测miR-99b-5p表达水平。利用RT-qPCR及蛋白质免疫印迹法检测转染miR-99b-5p ...
陈丽文 +7 more
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Study on the effect of myocardial injury induced by electrical injury in mice based on metabolomics [PDF]
Objective To study myocardial injury induced by electrical injury in mice based on metabolomics, and to find out the differential metabolites and pathways in cardiac metabolism omics.
CHEN Siyu +9 more
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Evaluation of Cardiac Structure and Function in Patients with Wilson Disease Based on RT-3DE: a Clinical Study [PDF]
, 2023 Background Wilson disease (WD) is a rare autosomal recessive disease that causes impaired copper excretion, mainly manifestedashepatic and/or neuropsychiatric symptoms, but diversifies with the varying affected organs and severity of the disease.
ZHANG Yu, WANG Meixia, ZHANG Jing, WANG Fei, LI Zhonglei, ZHANG Yanyun, JIANG Zhenzhen
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Study on the mechanism of trimethylamine oxide damaging cardiac function in mice with hypertrophic cardiomyopathy [PDF]
Objective·To investigate the effects of trimethylamine oxide (TMAO) on cardiac function in mice with hypertrophic cardiomyopathy (HCM) and its potential molecular mechanism.Methods·Mice with myosin heavy chain 6 (Myh6) c.1211G>A (p.R404Q+/-) point ...
CHEN Hanzhang +8 more
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The Research of Fenofibrate’s Treatment in EAM Rat Model [PDF]
, 2012 心肌炎是指由各种病因引起的心肌肌层发生的局限或弥漫性炎症病变。其病理特征是弥散性心肌坏死和炎症细胞的侵润。其病因可以是各种感染，自身免疫反应及理化因素，且我国的心肌炎以病毒性心肌炎和自身免疫性心肌炎较为常见。但目前临床上针对其治疗的方法却不多，在调节免疫方面使用抗感染及免疫调剂类的药物，此类药物副作用严重，效果也一般，在临床应用上还是存在着很大的局限性。同时，对于心肌炎疾病的相关治疗一直在探索当中。 要想探索相关疾病的治疗，首先需要建立相关的模型。最早使用病毒建立病毒性心肌炎的模型。但是病毒不易取得 ...
刘源
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