, 2019 目的:采用整合生物信息学方法预测丹参治疗心血管疾病的潜在机制。方法:从PubChem数据库中搜索丹参靶标蛋白,从NCBI数据库中搜索心血管疾病相关基因,利用IPA比较、分析搜索结果,预测丹参治疗心血管疾病的交互作用分子网络。结果:丹参治疗心血管疾病的靶标蛋白主要有FASN、 PAFAH1B2、PLA2G7、PAFAH1B3和IL-1β,这些蛋白主要涉及LXR/RXR活化、动脉粥样硬化、肝纤维化/肝星形细胞活化、急性反应期信号、FXR/RXR活化等信号传导通路;交互作用分子网络主要涉及细胞运动 ...
代二琴 +6 more
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TRPC1/TRPC3 channels mediate lysophosphatidylcholine-induced apoptosis in cultured human coronary artery smooth muscles cells [PDF]
, 2016 溶血卵磷脂（lysophosphatidylcholine，lysoPC）是氧化低密度脂蛋白（oxidizedlow-densitylipoprotein，ox-LDL）的主要成分。早期的研究表明，lysoPC可诱导人冠状动脉平滑肌细胞（humancoronaryarterysmoothmusclecells，HCASMCs)凋亡，但具体机制尚不清楚。近期，我们通过细胞活力测定，流式细胞术，共聚焦显微镜及分子生物学手段对lysoPC作用的分子机制进行研究发现，lysoPC可引发细胞外钙离子内流 ...
王渊
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Function of Apoptosis and Autophagy in Cardiovascular Diseases [PDF]
, 2017 细胞凋亡与自噬是普遍存在于各种细胞内的生命现象,广泛参与了机体的生理、病理过程,且二者有着多因子、多通路的相互影响,这种错综复杂的关系贯穿于各种心血管疾病的始终,对多种心血管疾病的发生发展转归起重要作用。现对细胞凋亡与自噬及其相互关系进行梳理,并综述其在心血管疾病中的作用。Apoptosis and autophagy are common life phenomenon in various cells, which widely involve in physiological and ...
杨雅瑾, 林小凤, 费燕, 陈尚瑜
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Research Progress on the Influence of Intermittent Fasting on Cardiovascular Disease Risk Factors [PDF]
, 2022 In recent years, the prevalence and mortality of cardiovascular diseases in China have shown a significant upward trend, cardiovascular disease has become a major disease endangering the health of Chinese residents.
CUI Yanru, CEN Qiuyu, WEI Juanfang, WANG Wenchun, ZHANG Anren
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2016 Consensus statement on prevention of atherosclerotic cardiovascular disease in the Hong Kong population [PDF]
, 2017 published_or_final_versio
Cheng, CH +11 more
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Reducing the Risk of Adverse Events in Patients with Type 2 Diabetes Who are Poorly Treated with Metformin Combined with Acarbose：Dipeptidyl Peptidase-4 Inhibitor is Better Than Insulin [PDF]
, 2022 BackgroundClinically, when metformin (Met) combined with acarbose (Aca) cannot achieve the ideal hypoglycemic effect, a third drug will be usually added, such as insulin (Ins) or dipeptidyl peptidase-4 inhibitor (DPP-4i) etc., but there are few reports ...
SU Peng, LIU Yukun, LIANG Xiaohua, LIU Xin, YU Yaohui, HUANG Pengfei, BAI Yuru, HE Xiaoyan, SHEN Zhihong, MA Dong
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Arsenic Trioxide Induces T cell Apoptosis and Prolongs Islet Allograft Survival in Mice [PDF]
, 2015 目的：作为一种最有潜力的I型糖尿病的治疗方法，胰岛移植目前已经应用于临床。然而，免疫因素特别是T细胞介导的移植物活性损伤与功能丧失是胰岛移植应用的一大障碍。一直以来，科学家们都在寻找适用于胰岛移植的新型免疫抑制剂。三氧化二砷是临床上治疗早幼粒细胞白血病的特效药，最近被证明能够抑制同种异体心脏移植排斥反应。在此基础上，本文研究了三氧化二砷对同种异体胰岛移植免疫排斥的抑制作用，以及三氧化二砷与雷帕霉素联合诱导免疫耐受的可能作用机制。 方法：我们首先检测了三氧化二砷对胰岛细胞的毒性作用 ...
高畅
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WHO cardiovascular disease risk prediction model performance in 10 regions, China [PDF]
, 2023 Objective To validate the World Health Organization (WHO) non-laboratory-based cardiovascular disease risk prediction model in regions of China. Methods We performed an external validation of the WHO model for East Asia using the data set of China ...
Bennett, Derrick +17 more
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浙江大学学报. 医学版目的评估经导管二尖瓣瓣中瓣置换术（ViV-TMVR）置入SAPIEN 3瓣膜治疗二尖瓣生物瓣衰败患者的1年随访结果。方法回顾性分析2022年11月至2024年7月在四川大学华西医院接受ViV-TMVR治疗的26例二尖瓣生物瓣衰败患者的临床资料。患者年龄为71.5（64.5，74.5）岁，69.2%为女性。外科生物瓣置入（9.7±3.7）年后发生衰败，最常见的类型是狭窄合并反流（53.8%）。经房间隔或心尖入路置入生物瓣，于患者术前、术后即刻，以及术后1、6个月和1年进行超声心动图检查 ...
冉 泽超 +7 more
doaj +1 more source