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Journal of Diabetes, Volume 15, Issue 8, Page 685-698, August 2023., 2023 Highlights Vascular complication is one of the most important causes of death in diabetes patients. Arterial stiffness plays a key role in the progress of diabetes vascular complication; therefore, the improvement of arterial stiffness could inhibit the process of atherosclerosis and reduce the burden of diabetes vascular complications This study first
Jincheng Wang +14 more
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Journal of Diabetes, Volume 15, Issue 7, Page 545-556, July 2023., 2023 Highlights High stress hyperglycemia ratio (SHR) was associated with elevated systematic inflammation in diabetic inpatients with pneumonia on admission. In the absence of hypoglycemia on admission, SHR was of J‐shaped associations with adverse clinical outcomes in diabetic inpatients with pneumonia of different severity.
Bing Liu, Yu Chen, Liping Yu, Min Zhou
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Journal of Diabetes, Volume 15, Issue 7, Page 557-568, July 2023., 2023 Highlights The association between stress hyperglycemia ratio (SHR) and long‐term outcomes was still controversial. Based on a large prospective multicenter cohort, we found that high SHR levels were independently associated with increased risk of major adverse cardiovascular events (MACE), all‐cause death, and unplanned revascularization. Associations
Guyu Zeng +18 more
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TRPC1/TRPC3 channels mediate lysophosphatidylcholine-induced apoptosis in cultured human coronary artery smooth muscles cells [PDF]
, 2016 溶血卵磷脂（lysophosphatidylcholine，lysoPC）是氧化低密度脂蛋白（oxidizedlow-densitylipoprotein，ox-LDL）的主要成分。早期的研究表明，lysoPC可诱导人冠状动脉平滑肌细胞（humancoronaryarterysmoothmusclecells，HCASMCs)凋亡，但具体机制尚不清楚。近期，我们通过细胞活力测定，流式细胞术，共聚焦显微镜及分子生物学手段对lysoPC作用的分子机制进行研究发现，lysoPC可引发细胞外钙离子内流 ...
王渊
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Journal of Diabetes, Volume 15, Issue 5, Page 368-381, May 2023., 2023 Highlights This study is the first registered meta‐analysis with three different insights to explore the relationship between the glycated hemoglobin (HbA1c) variability and the risk of cardiovascular disease (CVD). Our study suggests that the higher glucose fluctuation is significantly associated with the higher CVD risk in diabetes patients based on ...
Feng Li +6 more
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, 2019 目的:采用整合生物信息学方法预测丹参治疗心血管疾病的潜在机制。方法:从PubChem数据库中搜索丹参靶标蛋白,从NCBI数据库中搜索心血管疾病相关基因,利用IPA比较、分析搜索结果,预测丹参治疗心血管疾病的交互作用分子网络。结果:丹参治疗心血管疾病的靶标蛋白主要有FASN、 PAFAH1B2、PLA2G7、PAFAH1B3和IL-1β,这些蛋白主要涉及LXR/RXR活化、动脉粥样硬化、肝纤维化/肝星形细胞活化、急性反应期信号、FXR/RXR活化等信号传导通路;交互作用分子网络主要涉及细胞运动 ...
代二琴 +6 more
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Function of Apoptosis and Autophagy in Cardiovascular Diseases [PDF]
, 2017 细胞凋亡与自噬是普遍存在于各种细胞内的生命现象,广泛参与了机体的生理、病理过程,且二者有着多因子、多通路的相互影响,这种错综复杂的关系贯穿于各种心血管疾病的始终,对多种心血管疾病的发生发展转归起重要作用。现对细胞凋亡与自噬及其相互关系进行梳理,并综述其在心血管疾病中的作用。Apoptosis and autophagy are common life phenomenon in various cells, which widely involve in physiological and ...
杨雅瑾, 林小凤, 费燕, 陈尚瑜
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2016 Consensus statement on prevention of atherosclerotic cardiovascular disease in the Hong Kong population [PDF]
, 2017 published_or_final_versio
Cheng, CH +11 more
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Arsenic Trioxide Induces T cell Apoptosis and Prolongs Islet Allograft Survival in Mice [PDF]
, 2015 目的：作为一种最有潜力的I型糖尿病的治疗方法，胰岛移植目前已经应用于临床。然而，免疫因素特别是T细胞介导的移植物活性损伤与功能丧失是胰岛移植应用的一大障碍。一直以来，科学家们都在寻找适用于胰岛移植的新型免疫抑制剂。三氧化二砷是临床上治疗早幼粒细胞白血病的特效药，最近被证明能够抑制同种异体心脏移植排斥反应。在此基础上，本文研究了三氧化二砷对同种异体胰岛移植免疫排斥的抑制作用，以及三氧化二砷与雷帕霉素联合诱导免疫耐受的可能作用机制。 方法：我们首先检测了三氧化二砷对胰岛细胞的毒性作用 ...
高畅
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