Protective Effect and Mechanism of Ursolic Acid on Acute Alcoholic Liver Injury in Mice [PDF]
Objective: In this study, the protective effect of ursolic acid (UA) against acute alcohol-induced liver injury in mice and the mechanism involved was explored. Methods: Forty specific-pathogen-free male ICR mice were randomly assigned to control, model,
Kaihui LIU +5 more
core +1 more source
Comparative Metabolomics Revealed Metabolite Differences in Bamboo Shoots (Chimonobambusa tumidissinoda Hsueh & T. P. Yi ex Ohrnberger) at Different Growth Stages [PDF]
, 2023 In order to explore the dynamic changes and stage specificity of metabolites in bamboo shoots during its growth, widely targeted metabolomics based on ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was used to analyze ...
WANG Weihua, YANG Xiaoqin, SANG Zhenglin, YANG Shunqiang, ZHAO Ping, LIU Yun, ZHU Guolei, YE Xiaying
core +1 more source
pink1-prkn PARK2通路与线粒体自噬和肝脏急性缺血再灌注损伤的关联研究
Zhongguo shiyan zhenduanxue, 2018 目的探讨pink1-prkn PARK2通路与线粒体自噬和肝脏急性缺血再灌注损伤的关联。方法选择C57BL/6小鼠,将Pink1-KO小鼠与Park2-KO小鼠杂交以产生Pink1Park2double-KO小鼠,制作肝脏急性缺血再灌注损伤模型。取肝脏组织行SP3的免疫组织化学染色。用质粒DNA或RNAi瞬时转染HK-2细胞;HK-2细胞在含20mM CCCP的无糖RKRB缓冲液诱导ATP耗竭,模拟再灌注;进行细胞凋亡分析;分离线粒体,测量线粒体DNA(mtDNA)的相对含量;测量HK ...
刘树雄, 何建
doaj
Protective effect of Axin against acetaminophen-induced acute liver injury via promoting GSH synthesis [PDF]
, 2017 Axin作为一个多功能的构架蛋白，参与调节Wnt，AMPK，mTOR，JNK和P53等多种信号通路，对维持细胞物质和能量代谢的平衡有重要作用。Axin全身敲除致死，目前人们对Axin在组织和器官水平中所扮演的角色了解的并不多。我们成功构建了肝脏特异性敲除Axin基因的小鼠，肝脏是机体最大的解毒器官同时也是物质代谢的核心场所，其正常运作对维持健康至关重要。 过量服用对乙酰氨基酚会诱发急性肝损伤，这是因为毒性代谢物耗竭谷胱甘肽后会直接攻击肝细胞，同时启动各种应激途径进而导致细胞死亡 ...
林慧格
core
, 2015 目的探讨临床药师参与临床治疗典型病例的用药措施和效果。方法通过文献检索分析阐述美罗培南的常见不良反应,结合临床案例分析评价治疗方案,提出药学建议进行药学监护。结果临床药师的建议被部分采纳,患儿肝功能好转并出院。结论临床药师参与临床并提供药学重整服务 ...
魏吟秋
core
Mechanistic study on the alleviation of LPS-induced hepatocyte injury by thymic stromal lymphopoietin [PDF]
Objective To explore the mechanism of thymic stromal lymphopoietin (TSLP) in regulating lipopolysaccharide (LPS) -induced inflammation in mouse hepatocytes. Methods Ten male C57BL/6J wild-type (WT) mice and 10 male TSLP receptor-deficient (TSLPR-/-) mice
Jiarui ZHANG, Shaolei WU, Shilai LI
core +1 more source
Zhongguo shiyan zhenduanxue, 2014 目的探讨丹参磷脂浸膏（DSLZ）对实验小鼠肝损伤的保护作用。方法 ICR小鼠60只,随机分为空白对照组、模型组及丹参磷脂浸膏高、中、低剂量组和阳性对照丹参酮IIA（SalviolⅡA IIA）组,采用四氯化碳（CCl4）法建立急性肝损伤实验动物模型,观察丹参磷脂浸膏对实验小鼠血清丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）、丙二醛（MDA）、还原型谷胱甘肽（GSH）以及肝组织病理改变的影响。结果与空白对照组比较,模型组小鼠血清ALT、AST及MDA均显著增高 ...
付丹阳 +4 more
doaj
Zhongguo shiyan zhenduanxue, 2015 妊娠期急性脂肪肝(acute fattyliver ofpregnancy,AFLP)是发生在妊娠晚期的一种严重并发症,多见于初产妇,发病率为1/7 270-1/13 000。该病主要病变为肝脏脂肪变性,常急性发病,病情凶险,并伴有多脏器损伤,母婴死亡率可高达20%左右[1]。
钟莉莉, 郭迎雪, 吴凡, 赵银龙
doaj
Progress on the Extraction, Structure Characterization and Bioactivity of Schisandra chinensis Polysaccharides [PDF]
Schisandra chinensis refers to the dried mature fruit of the plant Schisandra chinensis (Turcz.) Baill from the Magnoliaceae family, or Schisandra sphenanchera Rehd. etWils.
Haoxiang CHEN, Zhou SI, Ziluan FAN
core +1 more source
Role and Mechanism of Freeze-Dried Powder of Phyllanthus emblica L. in Antagonizing Liver Injury Induced by Subacute Cadmium Exposure in Mice [PDF]
Objective: To investigate the effect of freeze-dried powder of Phyllanthus emblica L. (PEFP) on cadmium chloride (CdCl2)-induced subacute liver injury in mice and to analyze the underlying mechanism by transcriptomics. Methods: Male KM mice were randomly
ZHAO Bo, GU Shiyan, MEI Zongqin, LI Wenhong, MA Shunrong, SHEN Kaiyan, HE Zuoshun
core +1 more source