Results 11 to 20 of about 203,742 (173)
Improvement of BepiColombo's radio science experiment through an innovative Doppler noise reduction technique [PDF]
, 2018 The Mercury Orbiter Radio science Experiment (MORE), onboard the ESA/JAXA BepiColombo mission to Mercury, is designed to estimate Mercury’s gravity field, its rotational state, and to perform tests of relativistic gravity.
DI RUSCIO, ANDREA +3 more
core +1 more source
REGULATORY MECHANISMS OF NITRIC OXIDE ON THE BASOLATERAL CHLORIDE CHANNELS IN THE THICK ASCENDING LIBM OF KIDNEY [PDF]
, 2016 位于肾脏髓袢升支粗段（TAL）管周膜侧的氯通道在机体对Cl-的重吸收过程中发挥着十分关键的作用。本研究拟利用细胞贴附式膜片钳技术来观察一氧化氮（NO）是否通过抑制管周膜侧氯通道的活性来减少TAL对NaCl的重吸收以及这种抑制作用是否是通过环磷酸鸟苷（cGMP）依赖的蛋白激酶G（PKG）途径来实现的。实验结果表明，体外急性添加一氧化氮合酶（NOS）作用底物L-精氨酸以及NO外源性供体SNAP均能显著抑制TAL管周膜侧10-pS氯通道的活性。然而，存在NOS抑制剂或NO清除剂条件下，我们并未观察到L ...
吴鹏
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Fighting Corruption Through Accountability? A Survey Experiment 感覺課責能否抑制貪腐?來自調查實驗的證據
Public Administration, EarlyView.ABSTRACT Democratic Weberian bureaucracy is facing great challenges upholding public values as we see turbulent party politics disrupt merit‐based systems, causing bureaucrats' goal displacement and conflicting compliance under multiple accountability mechanisms.
Ming‐feng Kuo, Hsini Huang
wiley +1 more source
The effects of axon guidance factor Slit3 on metastasis of human fibrosarcoma [PDF]
, 2015 我们通过在纤维肉瘤细胞HT1080过表达Slit3基因，分析Slit3对肿瘤细胞侵袭转移作用.Transwell侵袭实验中，Slit3过表达后抑制HT1080的迁移侵袭，在裸鼠皮下成瘤实验中，肿瘤体积明显变小、重量明显降低，Slit3过表达后抑制HT1080肿瘤细胞的侵袭转移。此外肿瘤切片HE染色后发现GFP组有病灶点，而slit3过表达则少见，这个结果说明，Slit3显著抑制HT1080细胞转移。slit3过表达后MMP2,MMP9的表达明显降低，而MMP3，MMP13表达量上调 ...
刘咏梅
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Rare Metals, Volume 45, Issue 5, May 2026.ABSTRACT The inherent brittleness of hardmetals stems from the rigid covalent bond in the ceramic matrix and the sharp ceramic/metal interface, which restricts the nucleation and motion of dislocations. In this study, a novel strategy is proposed to activate significant dislocation behaviors in the WC matrix by employing a non‐equiatomic CoNiFeCr ...
Cheng Qian +9 more
wiley +1 more source
Radical seavenging activity of heated-pectin oligosaccharide [PDF]
, 2000 AOM誘発ラット大腸発癌を抑制するアップルペクチンについて，発癌の過程に関わっている活性酸素に対する抑制効果を明らかにするため，アップルペクチン由来オリゴ糖，特に，加熱処理別およびメトキシル化度別による活性酸素抑制率の分析を行った。アップルペクチン由来のオリゴ糖は，平均重合度により，S，M，L，LLの4 群に分けた。S分画は加熱温度別にも分析した。更に，高メトキシルと低メトキシル化度別に加熱処理後の変化について分析した。アップルペクチン由来オリゴ糖の重合度別各分画による加熱処理後の・O2-及び ...
並川 宏英 +10 more
core +1 more source
Rare Metals, Volume 45, Issue 5, May 2026.ABSTRACT Laser powder bed fusion (LPBF) can fabricate high‐entropy alloys (HEAs) with refined microstructure and enhanced mechanical properties. However, the deformation and fatigue mechanisms of Al‐containing HEAs produced by LPBF remain unclear. In this work, we systematically investigate the tensile properties, deformation mechanisms, and high‐cycle
Dan Zheng +4 more
wiley +1 more source
Design and synthesize oxazolidinone NAAA inhibitors，evaluate its pharmacological effects and toxicity [PDF]
, 2015 研究背景：N-棕榈酰乙醇胺（N-palmitoylethanolamide,PEA）是一种内源性的脂质，通过抑制内源性大麻素水解酶N-酰基乙醇胺水解酶（NAAA）的活性可有效提高细胞和动物机体内PEA浓度，从而发挥镇痛，抗炎，抗癫痫，神经保护等作用。然而现有的NAAA抑制剂活性低、稳定性差，无法应用于整体动物实验和口服给药，所以研制出新型的NAAA抑制剂成了当务之急。 目的：本研究通过设计合成一系列噁唑烷酮类NAAA抑制剂，从中寻找到结构稳定，活性强，毒副作用小的化合物 ...
李燕婷
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Rare Metals, Volume 45, Issue 5, May 2026.ABSTRACT Lithium‐selenium (Li‐Se) batteries have attracted considerable attention due to their high theoretical specific capacity and the intrinsically good electronic conductivity of selenium. Nevertheless, low active‐material utilization, parasitic side reactions, and sluggish reaction kinetics hinder their practical application.
Yanan Fu +8 more
wiley +1 more source
The toxicity of Rapamycin derivatives—Everolimus, Deforolimus, Zotarolimus on islet [PDF]
, 2016 目的：免疫抑制剂的开发与运用一直推动着器官移植领域的发展。自21世纪初，Edmonto方案被提出以后，胰岛移植领域发生的了质的飞跃，尤其是雷帕霉素与他克莫司的开发与利用，使得该方案得到广泛的认可与临床运用。然而随着研究的不断深入，研究者们发现免疫抑制剂在延长移植物存活时间的同时，也给胰岛本身带来了严重的毒性作用，包括抑制胰岛细胞增殖，促进胰岛细胞凋亡，抑制胰岛细胞分泌胰岛素等。应用免疫抑制剂产生的这些不良反应在抗器官移植排斥反应时发生。它们作为抗肿瘤药物应用于临床时也会诱发高血糖的现象。所以 ...
张娟
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