Results 11 to 20 of about 644,673 (177)
浙江大学学报. 医学版开发高效且特异的瞬时受体电位M2型（TRPM2）通道抑制剂，不仅有助于深化对相关疾病病理机制的理解，还能为临床治疗提供新的有效靶点和候选药物。根据研发方法不同，TRPM2通道抑制剂的开发主要分为四类，分别有以下特点：同源离子通道调节剂的再利用及结构改造能够发现多种抑制效果较强的TRPM2通道抑制剂；基于通道开放机制开发所得的TRPM2通道抑制剂通常表现出良好的选择特异性；高通量筛选开发所得的抑制剂往往具备新颖的化学结构，丰富了TRPM2通道抑制剂的设计思路；开发源于天然抗氧化剂的抑制剂则具备较高安全性 ...
陈 世尧 +4 more
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Beyond Evidence: How Framing Shapes Public Health Policies During Health Crises
Policy Studies Journal, Volume 54, Issue 4, November 2026.ABSTRACT Does the level of evidence that accompanies policy action depend on how a problem is framed, and on who frames it? This article examines these questions in the context of health crises. Bridging sociological and equivalence framing theories, it treats frames as preexisting interpretive schemes shared within communities of actors, whose ...
Antoine Claude Lemor, Eric Montpetit
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Rare Metals, Volume 45, Issue 10, October 2026.ABSTRACT Systematic studies on the fatigue deformation and damage mechanisms of nickel‐based single‐crystal superalloys (Ni‐SXs) under combined thermal and mechanical conditions remain limited, particularly regarding the influence of strain amplitude on the relative contributions of fatigue and oxidation damage.
Liyin Zhang +7 more
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Zhongguo shiyan zhenduanxue, 1998 目的探讨蛋白质磷酸化酶抑制剂对肺癌细胞株的增殖抑制作用。方法用蛋白质磷酸化酶抑制剂对６株小细胞肺癌和７株非小细胞肺癌细胞株的增殖抑制效果进行了检测，并采用免疫法，测定了蛋白质磷酸化酶抑制剂对肺癌细胞内Ｒｂ蛋白表达的影响。结果随其浓度的增加，对肺癌细胞株的增殖抑制作用增强，小细胞肺癌的半数抑制量平均值ＳＴ为９５ｎＭ，ＵＣＮ－０１为５８８ｎＭ，非小细胞肺癌则分别为１８８ｎＭ和１０２９ｎＭ，ＳＴ和ＵＣＮ－０１可抑制肺癌细胞Ｒｂ蛋白的磷酸化。结论蛋白质磷酸化酶抑制剂通过抑制Ｒｂ蛋白的磷酸化 ...
赵美蓉, 王杨, 裴瑞莲
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Enhanced Corrosion Resistance in an Additively Manufactured Copper Alloy via Suppressed Segregation
Rare Metals, Volume 45, Issue 10, October 2026.ABSTRACT This study elucidates the corrosion behavior of C18150 Cu–Cr–Zr alloy fabricated by laser powder bed fusion (LPBF) in comparison with a conventional wrought baseline representative of industrial Cu–Cr–Zr plate products, highlighting the superior corrosion resistance of the additively manufactured condition.
Yang Qi +4 more
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Rare Metals, Volume 45, Issue 10, October 2026.ABSTRACT Aqueous Zn‐ion batteries (AZIBs) are expected to become one of the most promising candidates for large‐scale energy storage, but are impeded by uncontrollable dendrite growth and parasitic reactions. In this study, we propose a simple mechanical shot‐peening (SP) approach for restructuring commercial Zn foils into highly exposed (002)‐textured
Xu Ma +7 more
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Rare Metals, Volume 45, Issue 10, October 2026.ABSTRACT Lithium‐rich manganese‐based cathodes (LRM) deliver high discharge capacities beyond 250 mAh g−1, but their practical deployment is restricted by irreversible oxygen redox, structural reconstruction, sluggish kinetics and unstable cathode‐electrolyte interfaces (CEI). Here, we develop a colloid‐assisted anchoring‐diffusion engineering strategy
Jia‐Nan Hao +13 more
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Rare Metals, Volume 45, Issue 10, October 2026.ABSTRACT Photocatalytic hydrogen peroxide (H2O2) production from water and oxygen driven by solar energy represents a highly promising green and sustainable strategy. Herein, lignin‐derived carbon quantum dots (LCDs) were strategically introduced at the heterojunction between a Bi‐based metal organic framework (Bi‐MOF) and ZnIn2S4 (ZIS).
Wanpeng Sun +8 more
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四川大学学报. 自然科学版, 1998 从玉米种子纯化出两种巯基蛋白酶抑制剂（ＣＰＩ Ⅰ和ＣＰＩ Ⅱ），分子量分别为９５００和１３０００，它们都只抑制巯基蛋白酶的水解活性，而对丝氨酸蛋白酶则无抑制作用，属于巯基蛋白酶水解抑制剂，它们在ｐＨ３．０～１１．０或１００℃温度范围内保有１００％的抑制木瓜蛋白酶的抑制活性，表明在这些外界条件下其分子非常稳定．
邓俊林, 曾仲奎
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