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浙江大学学报. 医学版开发高效且特异的瞬时受体电位M2型（TRPM2）通道抑制剂，不仅有助于深化对相关疾病病理机制的理解，还能为临床治疗提供新的有效靶点和候选药物。根据研发方法不同，TRPM2通道抑制剂的开发主要分为四类，分别有以下特点：同源离子通道调节剂的再利用及结构改造能够发现多种抑制效果较强的TRPM2通道抑制剂；基于通道开放机制开发所得的TRPM2通道抑制剂通常表现出良好的选择特异性；高通量筛选开发所得的抑制剂往往具备新颖的化学结构，丰富了TRPM2通道抑制剂的设计思路；开发源于天然抗氧化剂的抑制剂则具备较高安全性 ...
陈 世尧 +4 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 2015 摘 要： 【目的】 研究盘状结构域受体（ＤＤＲ１）的抑制剂３－（２－（吡唑并［１，５－ａ］嘧啶－６－基）乙炔基）苯甲酰胺７ＲＨ对鼻咽癌细胞的体外抗肿瘤作用及相关机制，为该药用于鼻咽癌的临床治疗提供实验依据。【方法】 采用ＭＴＴ法绘制细胞生长曲线，计算７ＲＨ对鼻咽癌细胞的半数抑制浓度（ＩＣ５０值）；Ｗｅｓｔｅｒｎ Ｂｌｏｔ检测７ＲＨ引起鼻咽癌细胞中信号通路的改变，并检测ＳｉＲＮＡ瞬时转染方法干扰ＤＤＲ１后ｐｈｏｓｐｈｏ－ＩＧＦ－１Ｒ的改变。【结果】 ７ＲＨ在体外明显抑制鼻咽癌细胞的增殖并且呈浓度依赖性 ...
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コミュニケーション回避としての発言抑制発生機序モデルの検討 [PDF]
, 2022 本研究は、坂本・プリブル・キートン（1998）のコミュニケーション回避に関する理論モデルを基に発言抑制に関する仮説モデルを構築し検証したものである。発言抑制に関する遺伝的素質として行動抑制系（BIS）、早期に作られる認知的機構として不合理な信念を想定し、それらによって生じる状態不安が発言抑制を発生させるという仮説の下、理論上時間的に先行する概念から現在の状態へとパス図の構成要素を配置し、因果関係を想定している。 170名の大学生に対する質問紙調査を実施した。因子分析の結果、大学生の発言抑制は ...
コヤマ, ケンイチロウ +7 more
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Fighting Corruption Through Accountability? A Survey Experiment 感覺課責能否抑制貪腐?來自調查實驗的證據
Public Administration, EarlyView.ABSTRACT Democratic Weberian bureaucracy is facing great challenges upholding public values as we see turbulent party politics disrupt merit‐based systems, causing bureaucrats' goal displacement and conflicting compliance under multiple accountability mechanisms.
Ming‐feng Kuo, Hsini Huang
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Enhanced Corrosion Resistance in an Additively Manufactured Copper Alloy via Suppressed Segregation
Rare Metals, Volume 45, Issue 10, October 2026.ABSTRACT This study elucidates the corrosion behavior of C18150 Cu–Cr–Zr alloy fabricated by laser powder bed fusion (LPBF) in comparison with a conventional wrought baseline representative of industrial Cu–Cr–Zr plate products, highlighting the superior corrosion resistance of the additively manufactured condition.
Yang Qi +4 more
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Rare Metals, Volume 45, Issue 10, October 2026.ABSTRACT To meet the demand for high‐performance lightweight heat‐resistant materials in aerospace and automotive applications, a novel Al‐Fe‐Sc‐Zr heat‐resistant aluminum alloy was fabricated by laser powder bed fusion (L‐PBF). The effects of Mg content (1 wt%, 3 wt%, 5 wt%, and 7 wt%) on formability, microstructure, mechanical properties, and thermal
Xinyu Du +6 more
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Rare Metals, Volume 45, Issue 9, September 2026.ABSTRACT Epidermal bioelectronics is a transformative technology for continuous health monitoring and human‐computer interaction. However, the mechanical and physiological mismatch at the skin–device interface limits its long‐term application. Electrospun nanofiber membranes (ENMs), with their unique three‐dimensional hierarchical porous network and ...
Jiahua Ni +7 more
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Rare Metals, Volume 45, Issue 9, September 2026.ABSTRACT NiCoCrAlYTa coatings are widely used as bond coats in thermal barrier coating (TBC) systems for gas turbines and aeroengines to provide oxidation resistance and support the formation of a protective thermally grown oxide (TGO). Herein, high‐current pulsed electron beam (HCPEB) modification was utilized to strengthen a NiCoCrAlYTa coating by ...
Xiangcheng Li +6 more
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Gaoya dianqi, 2018 VFTO具有波前陡、幅值高、频带宽、持续时间长等特点,是GIS变电站及邻近电力设备安全的巨大威胁,必须采取措施对其进行抑制。现有的几种抑制方法均有一定的效果,也存在相应的缺陷。据此提出一种高频过电压抑制导线的设计。抑制导线由GIS母线改造的镂空螺线管及与之并联的电阻组成,安装方式与常规母线无异。在工频下,其正常进行电流、电压波的传输;当有高频过电压时,起抑制VFTO的作用。文中对高频过电压抑制导线抑制VFTO的机理进行了分析,说明了其抑制VFTO的优势。然后从抑制导线的结构分析其抑制VFTO的效果 ...
冯宇 +6 more
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