Results 11 to 20 of about 535,408 (183)

DDR1抑制剂与IGF-1R抑制剂联合应用及机制

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2015
摘 要: 【目的】 研究盘状结构域受体(DDR1)的抑制剂3-(2-(吡唑并[1,5-a]嘧啶-6-基)乙炔基)苯甲酰胺7RH对鼻咽癌细胞的体外抗肿瘤作用及相关机制,为该药用于鼻咽癌的临床治疗提供实验依据。【方法】 采用MTT法绘制细胞生长曲线,计算7RH对鼻咽癌细胞的半数抑制浓度(IC50值);Western Blot检测7RH引起鼻咽癌细胞中信号通路的改变,并检测SiRNA瞬时转染方法干扰DDR1后phospho-IGF-1R的改变。【结果】 7RH在体外明显抑制鼻咽癌细胞的增殖并且呈浓度依赖性 ...
doaj   +1 more source

コミュニケーション回避としての発言抑制発生機序モデルの検討 [PDF]

open access: yes, 2022
本研究は、坂本・プリブル・キートン(1998)のコミュニケーション回避に関する理論モデルを基に発言抑制に関する仮説モデルを構築し検証したものである。発言抑制に関する遺伝的素質として行動抑制系(BIS)、早期に作られる認知的機構として不合理な信念を想定し、それらによって生じる状態不安が発言抑制を発生させるという仮説の下、理論上時間的に先行する概念から現在の状態へとパス図の構成要素を配置し、因果関係を想定している。  170名の大学生に対する質問紙調査を実施した。因子分析の結果、大学生の発言抑制は ...
コヤマ, ケンイチロウ   +7 more
core  

Cantonese (Dis)investment by Cross‐Border Postgraduates in Hong Kong: Negotiating Competing Capitals and Multiple Identities Among Neoliberal Subjects

open access: yesInternational Journal of Applied Linguistics, EarlyView.
ABSTRACT One key strategy that local universities and the government of Hong Kong have adopted in recent years is attracting more students from Chinese Mainland to study at Hong Kong's higher education institutions and contribute to society after graduation.
Lingnan Zhang, Yue Peng
wiley   +1 more source

Fighting Corruption Through Accountability? A Survey Experiment 感覺課責能否抑制貪腐?來自調查實驗的證據

open access: yesPublic Administration, EarlyView.
ABSTRACT Democratic Weberian bureaucracy is facing great challenges upholding public values as we see turbulent party politics disrupt merit‐based systems, causing bureaucrats' goal displacement and conflicting compliance under multiple accountability mechanisms.
Ming‐feng Kuo, Hsini Huang
wiley   +1 more source

Marine Applications of Metal‐Modified FEVE Coatings on 6061 Aluminum Alloy for Enhanced Anti‐Corrosion and Anti‐Biofouling

open access: yesRare Metals, Volume 45, Issue 7, July 2026.
ABSTRACT This study developed a metal–modified fluoroethylene vinyl ether (FEVE) organic coating on 6061 aluminum alloy, supported by a micro‐arc oxidation (MAO) pretreatment layer, to enhance corrosion resistance and antifouling performance in marine environments.
Chang Liu   +5 more
wiley   +1 more source

A pH‐Responsive Biomimetic Nanoparticle Coated With Macrophage Membranes for Photothermal and Immunotherapy of Bladder Cancer

open access: yesRare Metals, Volume 45, Issue 7, July 2026.
ABSTRACT Tumor metastasis and recurrence are major reasons for the difficulty in curing cancer. Although some immunotherapy methods have been developed, they are still limited by immunosuppression, resulting in limited therapeutic efficacy against tumors.
Chen Ye   +4 more
wiley   +1 more source

Spatiotemporally Adaptive Bilayer Silk Fibroin–Polyvinyl Alcohol–Metformin Composite Coating on Biodegradable Zinc for Orthopedic Applications

open access: yesRare Metals, Volume 45, Issue 7, July 2026.
ABSTRACT Biodegradable zinc (Zn)‐based materials are considered promising candidates for orthopedic applications because of their favorable mechanical properties, controllable biodegradability, and good biosafety profiles. However, their clinical translation is limited by early‐stage corrosion‐induced cytotoxicity and inflammation, as well as ...
Jinlong Mao   +9 more
wiley   +1 more source

Synergy of Strength and Plasticity in Extruded VZ91K Magnesium Alloy Achieved by Constructing Bimodal Grain Structure via Suppression of PSN‐DRX

open access: yesRare Metals, Volume 45, Issue 7, July 2026.
ABSTRACT Bimodal grain structure (BGS) demonstrates significant potential in synergistically optimizing the strength and plasticity of magnesium alloys. Acquiring the desired BGS consequently became a critical challenge. This study took the Mg‐9Gd‐1Zn‐0.5Zr (wt%, VZ91K) alloy as its subject. From the perspective of BGS formation mechanisms, it suggests
Shuai Yuan   +5 more
wiley   +1 more source

Electric Field‐Induced Dark Current Steering in MAPbI3/Nb2CTx Photodetector Toward Weak‐Light Single‐Pixel Imaging

open access: yesRare Metals, Volume 45, Issue 7, July 2026.
ABSTRACT In conventional photoconductive detectors, the shared collection path for dark current and photocurrent imposes a fundamental compromise between noise suppression and signal responsivity. To break this trade‐off, we introduce a device architecture featuring a strategically integrated third electrode within a MAPbI3/Nb2CTx heterostructure. This
Yan‐Wei Lv   +7 more
wiley   +1 more source

抑制机制研究的新进展

open access: yes, 1999
在近几年的一些认知研究中, 抑制机制作为认知活动的一个重要维度开始受到越来越多的重视 ...
杨丽霞, 陈永明
core   +1 more source

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