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双相障碍抑郁发作及单相抑郁症患者与血清BDNF、GABA、TSH水平的相关性分析
Zhongguo shiyan zhenduanxue, 2020 目的探讨双相障碍抑郁发作及单相抑郁症患者与血清脑源性神经营养因子(BDNF)、γ-氨基丁酸(GABA)、促甲状腺激素(TSH)水平的相关性。方法选择2018年1月至2020年3月期间我院收治的抑郁症(n=59)、双相障碍抑郁发作(n=51)患者及健康志愿者(n=50)作为研究对象。采用汉密尔顿抑郁量表(HAMD-17)、心境障碍问卷(MDQ)、32项轻躁狂症状清单(HCL-32)评估各组受试者抑郁、狂躁或轻狂躁状态,测定血清BDNF、GABA、TSH水平。结果①双相障碍抑郁组、抑郁症组患者HAMD ...
李家君, 张浪, 李娟
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Zhongguo cuzhong zazhi, 2023 目的 探索性研究伴前庭症状的急性轻型卒中患者卒中后6个月焦虑抑郁状态的危险因素及神经功能恢复情况。 方法 前瞻性连续收集2020年9月—2022年9月首都医科大学附属北京天坛医院神经内科住院患者中伴发前庭症状的急性轻型卒中患者的人口学信息、卒中危险因素、发病前mRS评分、入院时NIHSS评分、卒中类型和部位。评估住院期间及卒中后6个月HAMA和HAMD评分。根据卒中后6个月HAMA和HAMD评估结果将患者分为焦虑抑郁组和非焦虑抑郁组 ...
王琰，李佳树，方瑞乐，刘改芬，鞠奕
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C、D级稳定期慢阻肺伴抑郁患者营养状况与抑郁程度、生活质量的关系研究
Zhongguo shiyan zhenduanxue, 2021 目的探讨C、D级稳定期慢阻肺伴抑郁患者营养状况与抑郁程度、生活质量的关系。方法 2018年1月至2019年10月门诊初诊的C、D级稳定期COPD患者80例,行汉密尔顿抑郁量表(HAD)及抑郁自评量表(SDS)测评,采用NRS-2002评分表行营养风险筛查。另记录患者的基本信息、肺功能、人体测量学指标(BMI、中上臂围)、血清白蛋白、mMRC评分并进行对比。结果 (1)76位患者中D级患者占72.4%,合并营养不良风险的患者(NRS≥3)占50.0%。(2)存在营养不良风险的患者更易合并中重度抑郁 ...
杨晓丽 +4 more
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Clinical Study on the Treatment of Depression Qi stagnation and Phlegm stagnation Syndrome with Chai Yu Wen Dan Decoction [PDF]
, 2016 背景: 抑郁症是由各种原因引起的，以显著而持久的情绪低落、兴趣和活动性减低为主要临床表现的精神障碍性心理疾病。现代社会由于生活工作压力增大、节奏变快、竞争激烈等，抑郁症的发病率呈上升趋势。抗抑郁西药应用于临床已半个多世纪，证实多数药物有确切的疗效，但仍然存在着抗抑郁谱窄、起效缓慢、存在不同程度不良反应、患者依从性较差等问题。近年来中药复方以其多途径、多靶点及多环节的综合药理效应治疗抑郁症已凸显一定优势。 目的: 1.通过文献研究探索中医药治疗抑郁症的优势所在 ...
郭冠呈
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Infant Mental Health Journal: Infancy and Early Childhood, Volume 46, Issue 5, Page 564-576, September 2025.Abstract Parental reflective functioning (PRF) is important in guiding parenting behavior. It is traditionally measured with interviews that are relatively time‐consuming. A self‐report measure of PRF, the Parental Reflective Functioning Questionnaire (PRFQ), has been developed but has not yet been extensively validated across different sociocultural ...
Marjo Flykt +4 more
wiley +1 more source
A Mendelian randomization study of depression and risk of cervical cancer (抑郁和宫颈癌发病风险相关的孟德尔随机化分析)
中西医结合护理, 2023 Objective To explore the causal relationship between depression and the risk of cervical cancer by Mendelian randomization(MR). Methods Based on Genome Wide Association Study(GWAS) data, single nucleotide polymorphism(SNP) associated with depression ...
LIU Yinxia (刘银侠) +2 more
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Studies on the antidepressant-like effect and prokinetic-like effects and the underlying mechanisms of Fructus aurantii and meranzin hydrate [PDF]
, 2016 目的：测定代表中药枳壳汤剂抗抑郁促动力(A&P)的吸收成分，初步阐明其A&P特别是抗抑郁的作用机理。 方法：1.含量测定。运用HPLC/MS/MS测定枳壳汤剂在空肠，海马和前额叶皮层吸收成分；2.急性抗抑郁疗效测试。该实验包括枳壳汤剂及其吸收成分水合橙皮内酯的急性抗抑郁疗效测试。该测试包括强迫游泳实验、旷场实验、习得性无助实验和新奇抑制实验；3.水合橙皮内酯的慢性抗抑郁疗效测试。包括强迫游泳实验和旷场实验；4.离体和在体胃肠动力实验；5.抗抑郁机制研究和抗抑郁促动力的共性机制研究 ...
柳进
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Effectiveness and treatment moderators of parenting interventions in Finnish perinatal primary care
Infant Mental Health Journal: Infancy and Early Childhood, Volume 46, Issue 5, Page 577-603, September 2025.Abstract Perinatal parenting interventions may be important for enhancing parenting quality, but previous research has mostly focused on parental sensitivity. Other important outcomes, such as parental self‐efficacy (PSE), have rarely been studied. Research is also contradictory on whether parenting interventions can also enhance maternal mental health
Marjo Flykt +6 more
wiley +1 more source
The Causal Relationship of Social Isolation, depression and the risk of Stroke among the Middle-Aged and the Elderly in China [PDF]
, 2016 摘要 目的本研究旨在探索中国中老年人社会隔离、抑郁与脑卒中发病风险的因果关系，以期阐明中国中老年人社会隔离和抑郁与脑卒中发病风险的影响，明晰抑郁在社会隔离和脑卒中发病关系链中的中介效应，进而对中国中老年人有效预防脑卒中提出相关建议。 方法本研究基于中国健康与养老追踪（ChinaHealthandRetirementLongitudinalStudy，CHARLS）调查中2011年-2013年2期的纵向数据，结局变量基于“医生诊断是否患有脑卒中”条目，抑郁变量由流调中心抑郁量表 ...
马佳平
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Validating the parental reflective functioning questionnaire ‐ infant version using a rasch model
Infant Mental Health Journal: Infancy and Early Childhood, Volume 46, Issue 4, Page 445-458, July 2025.Abstract Parental reflective functioning is the parent's ability to reflect on the psychological processes in their child and in themselves as a parent. Recently, an infant version of the Parental Reflective Functioning Questionnaire, PRFQ‐I, has been developed and validated using confirmatory factor analyses.
Anne Christine Stuart +4 more
wiley +1 more source