抗环瓜氨酸肽（抗-CCP）抗体检测在类风湿关节炎诊断中的应用价值
Zhongguo shiyan zhenduanxue, 2015 免疫机制是导致类风湿性关节炎的形成的重要因素之一,人体内的某种物质,可以是有病变产生的异常因子,也可是自身存在的正常因子,都可以作为抗原[1]。这些抗原均可以激活免疫系统里的细胞,使他们数量增多并被激活,同时,抗原提呈细胞APC发挥其自身的作用,作为一个中介和枢纽,将枢纽两端的事物联系起来,一端为来自于人体内部和（或）外界的抗原,另一端为CD204+T细胞 ...
霍爱鑫, 张苗, 赵辉, 王淑云
doaj
抗环瓜氨酸肽抗体与RF、CRP、ESR联合检测在RA诊断中的临床意义
Zhongguo shiyan zhenduanxue, 2012 类风湿性关节炎是临床常见的自身免疫性疾病之一,其病因未明。发病时常对称地累及多个周围关节,导致关节发生慢性炎症性改变,临床症状主要表现为受累关节疼痛、肿胀、功能障碍。病变常反复发作,迁延不愈。诊断主要根据美国风湿病学会（ACR）1987年提出的7项诊断标准,符合其中的4项即可诊断为类风湿性关节炎[1],主要依靠临床表现、X线检查以及类风湿因子（RF）检测进行诊断 ...
蔡淑静, 王海, 金玲, 谢风
doaj
Zhongguo shiyan zhenduanxue类风湿性关节炎（Rheumatoid arthritis RA）以慢性滑膜炎、组织退化和关节变形为特征[1]。不受控制的活动性类风湿关节炎会导致关节损伤、残疾、生活质量下降，以及心血管疾病的发生等[2]。目前临床实验室RA的检测指标主要有类风湿因子（RF）、抗环瓜氨酸肽抗体（CCP）、高敏C反应蛋白（hs-CRP）和血沉（ESR）等，这些指标并不能反映疾病的活动性和关节损伤程度[3]。
王伯玉, 张勤, 刘玲玲, 姚瀚鑫
doaj
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