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抗体药物偶联物治疗转移性去势抵抗性前列腺癌研究进展 [PDF]
浙江大学学报. 医学版转移性去势抵抗性前列腺癌（mCRPC）患者因肿瘤异质性和耐药性预后不佳，抗体药物偶联物（ADC）治疗mCRPC部分临床试验中已展现出抗肿瘤活性及较好的安全性。在靶向前列腺特异性膜抗原（PSMA）的ADC中，相较于早期ADC如MLN2704、PSMA-ADC、MEDI3726，ARX517安全性更优，前列腺特异性抗原下降更显著。在靶向B7-H3的ADC中，MGC018和DB-1311也展现出抗肿瘤活性。靶向前列腺六跨膜上皮抗原（STEAP）1的DSTP3086S、靶向滋养层细胞表面抗原（TROP ...
徐 嘉程 +5 more
doaj +2 more sources
Journal of Diabetes, Volume 15, Issue 7, Page 607-621, July 2023., 2023 Highlights The CD4 T cells of type 1 diabetes (T1D) patients particularly having HLA‐DRB1*03‐DQA1*05‐DQB1*02 haplotype are reactive against a particular region of the glutamic acid decarboxylase (GAD65) protein. GAD65 peptides encompassing 288–308 amino acid positions (peptide pool 2) may be favored by the HLA‐DR3 molecule for presentation to CD4 T ...
Neihenuo Chuzho +7 more
wiley +1 more source
Treatment of equine sarcoids using recombinant poxviruses expressing feline interleukin‐2
Veterinary Dermatology, Volume 32, Issue 3, Page 283-e77, June 2021., 2021 Background – Interleukin (IL)‐2 stimulates antitumour immunity and is successfully used for the treatment of different neoplasias. Hypothesis/Objectives –Canarypox virus locally expressing feline IL‐2 is safe and can be used to treat equine sarcoids. Conclusions –Treatment of equine sarcoids with recombinant canarypox virus expressing feline IL‐2 seems
Johanna Loschelder‐Ostrowski +4 more
wiley +1 more source
Antitumor activity of acidic ingredient from Solidago canadensis L(加拿大一枝黄花中酸性成分抗肿瘤活性初探)
Zhejiang Daxue xuebao. Lixue ban, 2007 探讨加拿大一枝黄花（Solidago canadensis L.）花序乙酸乙酯提取物中酸性成分体外及体内抗肿瘤活性.采用MTT法跟踪提取物细胞毒活性；用S180和EAC昆明小鼠模型进行提取物的体内抗肿瘤活性评价.结果表明，加拿大一枝黄花花序的酸性成分具有显著抑制多株人肿瘤细胞株生长的作用，并呈明显的量效关系.乙酸乙酯提取物中的酸性成分对小鼠移植性肿瘤S180和EAC的生长也有显著的抑制作用，并和剂量正相关，高剂量组对小鼠移植性肿瘤S180和EAC的抑制率分别为52.06%，32.90 ...
ZHUHong-ke(朱宏科) +5 more
doaj +1 more source
Zhejiang Daxue xuebao. Lixue ban, 2003 合成3种双核铂类配合物[{Pt(H2O)2I}μ—OOC—(CH2—)nCOO—{Pt(H2O)2I}](1~3)(n=0,1,2).用元素分析、摩尔电导、差热热重分析、红外光谱、紫外光谱和核磁共振氢谱等方法对其进行了表征.体外抗肿瘤活性表明,配合物1和3对多种人的肿瘤细胞有较高的活性,配合物2没有抗肿瘤活性.
ZHANGJin-chao(张金超) +6 more
doaj +1 more source
Zhongguo shiyan zhenduanxue, 2023 肿瘤新抗原(Tumor Neoantigen)又称为肿瘤特异性抗原，该抗原只在肿瘤细胞内表达而在正常细胞内不表达，并能被人白细胞分化抗原(HLA)I类分子识别、结合并递呈到肿瘤细胞表面，激活特异性T淋巴细胞，引发机体抗肿瘤免疫反应[1]。
秦续元 +4 more
doaj
Developmental Medicine &Child Neurology, Volume 61, Issue 3, Page E1-E35, March 2019., 2019 目的 本国际临床指南由欧洲残疾儿童学会（the European Academy of Childhood Disability，EACD）牵头制定，旨在解决发育性协调障碍（developmental coordination disorder，DCD）的定义、诊断、评估、干预以及与社会心理方面的临床应用关键问题。 方法 本指南针对五个领域的关键问题，通过文献综述和专家团队的正式讨论达成共识。为保证指南的循证基础，以“机制”、“评估”和“干预”为检索词, 对2012年更新以来提出的最新建议以及新增的“社会心理问题”和“青少年/成人”为检索词进行检索。根据牛津大学循证医学中心证据等级 (证据水平 [level of evidence, LOE]1–4) 将结果进行分类，最终转化为指南建议。并由国际 ...
Jing Hua +6 more
wiley +1 more source
UVA Assisted 4-Thiothymidine for Cancer Treatment [PDF]
, 2016 This article reviews the developments of 4-thiothymidine analogues, assisted with UVA light, as a novel cancer therapy. First, the key points on synthetic chemistry, photochemistry and cellular toxicity of 4-thiothymidine are summarized.
Feng, Luo +3 more
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Advances on the Effect of Processing Technology on Structure Activity Relationship and Solution Behavior of Polysaccharides [PDF]
, 2021 Polysaccharides are natural polymers formed by more than 10 monosaccharide molecules connected by glycoside bonds.The structure is the basis of the biological activity of polysaccharides.The structure of polysaccharides is complex and diverse, and its ...
FAN Liu-ping +5 more
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Optimization of Extraction Process and Evaluation of Antioxidant and Antitumor Activities of Total Flavonoids from Scutellaria barbata [PDF]
, 2023 The purpose of this experiment was to optimize the extraction process of total flavonoids from Scutellaria barbata and to evaluate the antioxidant and antitumor activity of total flavonoids. A single factor experiment combined with a response surface Box-
Min WEN +4 more
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