Results 1 to 10 of about 1,199,155 (156)

HLA‐DR3 mediated CD4 T cell response against GAD65 in type 1 diabetes patients HLA‐DR3介导的CD4 T细胞对1型糖尿病患者GAD65的应答

Journal of Diabetes, Volume 15, Issue 7, Page 607-621, July 2023., 2023
Highlights The CD4 T cells of type 1 diabetes (T1D) patients particularly having HLA‐DRB1*03‐DQA1*05‐DQB1*02 haplotype are reactive against a particular region of the glutamic acid decarboxylase (GAD65) protein. GAD65 peptides encompassing 288–308 amino acid positions (peptide pool 2) may be favored by the HLA‐DR3 molecule for presentation to CD4 T ...
Neihenuo Chuzho, Neetu Mishra, Nikhil Tandon, Uma Kanga, Gunja Mishra, Akanksha Sharma, Narinder K. Mehra, Neeraj Kumar   +7 more
wiley   +1 more source

Treatment of equine sarcoids using recombinant poxviruses expressing feline interleukin‐2

Veterinary Dermatology, Volume 32, Issue 3, Page 283-e77, June 2021., 2021
Background – Interleukin (IL)‐2 stimulates antitumour immunity and is successfully used for the treatment of different neoplasias. Hypothesis/Objectives –Canarypox virus locally expressing feline IL‐2 is safe and can be used to treat equine sarcoids. Conclusions –Treatment of equine sarcoids with recombinant canarypox virus expressing feline IL‐2 seems
Johanna Loschelder‐Ostrowski, Judith Christine Winter, Roswitha Merle, Robert Klopfleisch, Heidrun Gehlen   +4 more
wiley   +1 more source

Antitumor activity of acidic ingredient from Solidago canadensis L(加拿大一枝黄花中酸性成分抗肿瘤活性初探)

Zhejiang Daxue xuebao. Lixue ban, 2007
探讨加拿大一枝黄花（Solidago canadensis L.）花序乙酸乙酯提取物中酸性成分体外及体内抗肿瘤活性.采用MTT法跟踪提取物细胞毒活性；用S180和EAC昆明小鼠模型进行提取物的体内抗肿瘤活性评价.结果表明，加拿大一枝黄花花序的酸性成分具有显著抑制多株人肿瘤细胞株生长的作用，并呈明显的量效关系.乙酸乙酯提取物中的酸性成分对小鼠移植性肿瘤S180和EAC的生长也有显著的抑制作用，并和剂量正相关，高剂量组对小鼠移植性肿瘤S180和EAC的抑制率分别为52.06%，32.90 ...
ZHUHong-ke(朱宏科), LIUXiao-yue(刘晓月), WUShi-hua(吴世华), LIUFei-yan(刘非燕), CHENGYun-long(陈云龙), WUPing(吴平)   +5 more
doaj   +1 more source

Synthesis and antitumor activities of new generation binuclear platinum complexes(新型双核铂类配合物的合成及其抗肿瘤活性)

Zhejiang Daxue xuebao. Lixue ban, 2003
合成3种双核铂类配合物[{Pt(H2O)2I}μ—OOC—(CH2—)nCOO—{Pt(H2O)2I}](1~3)(n=0,1,2).用元素分析、摩尔电导、差热热重分析、红外光谱、紫外光谱和核磁共振氢谱等方法对其进行了表征.体外抗肿瘤活性表明,配合物1和3对多种人的肿瘤细胞有较高的活性,配合物2没有抗肿瘤活性.
ZHANGJin-chao(张金超), LIWen-xian(李文献), GONGYu-qiu(龚钰秋), ZHENGXiao-ming(郑小明), CUIJing-rong(崔景荣), WUJun(吴军), WANGRui-qing(王瑞卿)   +6 more
doaj   +1 more source

基于高通量测序肺腺癌个体化新抗原预测结果分析

Zhongguo shiyan zhenduanxue, 2023
肿瘤新抗原(Tumor Neoantigen)又称为肿瘤特异性抗原，该抗原只在肿瘤细胞内表达而在正常细胞内不表达，并能被人白细胞分化抗原(HLA)I类分子识别、结合并递呈到肿瘤细胞表面，激活特异性T淋巴细胞，引发机体抗肿瘤免疫反应[1]。
秦续元, 周平平, 宋旸, 杜珍武, 张桂珍   +4 more
doaj  

International clinical practice recommendations on the definition, diagnosis, assessment, intervention, and psychosocial aspects of developmental coordination disorder – Chinese (Mandarin) translation

Developmental Medicine &Child Neurology, Volume 61, Issue 3, Page E1-E35, March 2019., 2019
目的 本国际临床指南由欧洲残疾儿童学会（the European Academy of Childhood Disability，EACD）牵头制定，旨在解决发育性协调障碍（developmental coordination disorder，DCD）的定义、诊断、评估、干预以及与社会心理方面的临床应用关键问题。 方法 本指南针对五个领域的关键问题，通过文献综述和专家团队的正式讨论达成共识。为保证指南的循证基础，以“机制”、“评估”和“干预”为检索词, 对2012年更新以来提出的最新建议以及新增的“社会心理问题”和“青少年/成人”为检索词进行检索。根据牛津大学循证医学中心证据等级 (证据水平 [level of evidence, LOE]1–4) 将结果进行分类，最终转化为指南建议。并由国际 ...
Jing Hua, Wenchong Du, Xiaotian Dai, Meiqin Wu, Xianying Cai, Min Shen, Liping Zhu   +6 more
wiley   +1 more source

Harnessing Trace Elements: Novel Radiosensitization Strategies for Enhanced Cancer Radiotherapy

Rare Metals, Volume 45, Issue 6, June 2026.
ABSTRACT Radiotherapy (RT) is one of the core methods of comprehensive cancer treatment. Globally, more than 40% of cancer patients rely on radiotherapy to achieve tumor control, cure or palliative relief. However, radiation resistance, immunosuppression and normal tissue injury limit its clinical application.
Yuhuan Zhang, Yizhi Ge, Hongguang Xiang, Ji Liu, Yu Tian, Yan Shen, Dan Zong   +6 more
wiley   +1 more source

Ultrathin MnO2‐PEG‐PD‐L1 Nanosheets Enable Tumor Microenvironment Modulation and NIR‐II Photothermal Immunotherapy for Durable Control of Lung Cancer and Postoperative Recurrence

Rare Metals, Volume 45, Issue 6, June 2026.
ABSTRACT Lung cancer is one of the most common and deadly malignancies worldwide. Although immune checkpoint inhibitors, including PD‐1/PD‐L1 blockers, have benefited a subset of patients, response rates remain limited, and recurrence is frequent because of the immunosuppressive tumor microenvironment (TME), characterized by hypoxia and dysregulated ...
Yi Ma, Lingxi Zhu, Yingran Shen, Yue Liu, Hugang Liu, Kunpeng Zhang, Chao Jiang   +6 more
wiley   +1 more source

Titanium Implant Abutments With Polydopamine‐Mesoporous Cerium Dioxide Coatings for Enhanced Antibacterial, Anti‐Inflammatory, and Soft Tissue Integration Properties

Rare Metals, Volume 45, Issue 6, June 2026.
ABSTRACT The poor soft tissue integration around titanium implants creates a microgap that serves as a pathway for pathogen invasion, resulting in infection, inflammation, and the progression of peri‐implantitis. As the implant’s transmucosal component, the abutment determines the degree of peri‐implant soft tissue attachment.
Xuan Li, Min Xing, Haoyue Liu, Kuicai Ye, Xuanyong Liu, Li Ma, Wenhao Qian, Jiajun Qiu   +7 more
wiley   +1 more source

Metal‐Doped Carbon‐Based Nanomaterials: Photothermal Mechanism Innovation and Precision Therapy Advancement in Antibacterial and Antitumor Applications

Rare Metals, Volume 45, Issue 5, May 2026.
ABSTRACT Metal‐doped carbon‐based nanomaterials (M‐CNM) play a strategically significant role in next‐generation precision antibacterial and antitumor therapies, as they integrate synergistic photothermal ablation, catalytic reactive oxygen species (ROS) generation, and multimodal imaging capabilities. However, their clinical translation is hindered by
Pengxiang Liu, Juan Du, Guoqiang Ma, Zheng Li, Aibing Chen, Senlin Hou   +5 more
wiley   +1 more source