Results 31 to 40 of about 106,142 (160)
, 2010 肿瘤坏死靶向治疗(Tumor necrosis targeted therapy,TNT)是分子靶向治疗方法之一,针对肿瘤细胞核抗原的特异性抗体(肿瘤坏死靶向治疗抗体,TNT抗体)是肿瘤坏死靶向治疗的关键,嵌合性肿瘤细胞核单克隆抗体-3(chTNT-3)是目前临床实验效果最佳的TNT抗体,本文就TNT抗体的作用机制、chTNT-3及其衍生物治疗肿瘤的现状 ...
黄正接, 朱华群, 罗凌涛
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World Medical &Health Policy, Volume 16, Issue 4, Page 558-576, December 2024.Abstract Background Over the past decade, the ascent of personalized medicine (PM) has catalyzed pivotal transformations in healthcare systems on a global scale. Recognizing its crucial importance, the European Commission has prioritized PM within its research directives, allocating funding for international collaborative projects, such as the ...
Marzia Di Marcantonio +6 more
wiley +1 more source
Rare Metals, Volume 43, Issue 11, Page 6006-6022, November 2024.Graphical abstract AbstractCisplatin resistance is the main cause for the failure of cancer therapy. To solve the problem, we proposed to develop a novel human serum albumin (HSA) nanoplatform to integrate chemotherapy, photothermal therapy (PTT) and immunotherapy.
Xue‐Yu Man +7 more
wiley +1 more source
, 2000 细胞凋亡是一种细胞自主生理性死亡 ,对多细胞动物机体的正常发育和自身稳定具有极其重要的作用 ,细胞凋亡失衡与许多疾病尤其是与肿瘤的发生发展有关。近几年来 ,有关细胞凋亡分子机制的研究进展较快 ,对细胞凋亡在放疗、化疗等肿瘤治疗措施中的作用也有了进一步的认识 ...
李祺福, 洪水根, 欧阳高亮
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Cancer Medicine, Volume 13, Issue 12, June 2024.Abstract Background Undetermined lung nodules are common in locally advanced rectal cancer (LARC) and lack precise risk stratification. This study aimed to develop a radiomic‐based score (Rad‐score) to distinguish metastasis and predict overall survival (OS) in patients with LARC and lung nodules.
Zhiyuan Zhang +12 more
wiley +1 more source
MedComm, Volume 5, Issue 1, January 2024.H&E, IHC, mIHC, and spatial transcriptomics were implemented to analyze spatial and maturation heterogeneity of tertiary lymphoid structures (TLS) in ccRCC. Mature TLS within tumors participate in antitumor immunity and might serve as the locale for the generation of IgA and IgG plasma cell, predicting favorable prognosis and effectiveness of ...
Wenhao Xu +11 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2019 树突状细胞(DC)被确定为最有效的抗原递呈细胞(APC),操纵和刺激免疫系统的关键组成部分。DC通过促进肿瘤特异性细胞毒性T淋巴细胞(CLT)和辅助性T细胞(Th细胞)的产生和增殖,在诱导保护性和治疗性抗肿瘤免疫中发挥着关键作用[1]。研究者已经报道过许多肿瘤抗原(Ag)负载DC诱导高效抗肿瘤免疫反应,在小鼠肿瘤模型和肿瘤患者试验中均有[2 ...
刘锐 +5 more
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Zhongguo shiyan zhenduanxue, 2014 本实验从抗原提取方法入手,采用梯度盐水法对加热和未加热的肺腺癌细胞SPC-A-1进行肿瘤细胞提取物提取,以此作为抗原,比较不同方法提取的肿瘤抗原在体外与人外周血淋巴细胞共同培养后对肺腺癌细胞SPC-A-1的杀伤活性,探讨肿瘤抗原的有效获取方法以及不同浓度抗原对肿瘤细胞的体外杀伤效果,为肿瘤抗原的获取和临床应用提供实验数据。1材料和方法1.1细胞株SPC-A-1,购自上海生物细胞研究所。
赵鑫 +7 more
doaj
, 2010 本发明涉及抗肿瘤药物，具体地说为菊芋的有机溶剂提取物在制备抗肿瘤药物或抗肿瘤保健品中的应用。体外细胞实验表明，菊芋叶乙酸乙酯提取物对多种肿瘤细胞，如肺癌细胞株(A549)，乳腺癌细胞株(MCF-7)，宫颈癌细胞株(Hela)，肾癌细胞株(ACHN)均有抑制作用 ...
肖红斌 +4 more
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, 2019 目的分析常见铂类抗肿瘤药物不良反应并制定防治措施。方法抽取医院2016年4月-2018年4月接收的应用铂类抗肿瘤药物治疗患者468例,分析患者用药不良反应发生情况、类型及表现。结果 468例应用铂类抗肿瘤药物治疗患者中发生不良反应136例占29.06%,顺铂发生率最高占44.31%,其次为奥沙利铂占27.91%,各药物不良反应发生率比较差异有统计学意义(χ~2=24.623 ...
陈煜
core +1 more source