Results 11 to 20 of about 2,348 (149)
Veterinary Dermatology, Volume 27, Issue 5, Page 391-e98, October 2016., 2016 Background– Pseudomonas aeruginosa (PA) may cause suppurative otitis externa with severe inflammation and ulceration in dogs. Multidrug resistance is commonly reported for this organism, creating a difficult therapeutic challenge. Objective– The aim of this study was to evaluate the in vitro antimicrobial activity of a gel containing 0.5 µg/mL of ...
Giovanni Ghibaudo +6 more
wiley +1 more source
, 2018 BioMed Research International, Volume 2018, Issue 1, 2018.
Hongming Ji +11 more
wiley +1 more source
Biodegradable Mg Alloys: Enhancing Anti‐tumor Immunity in Cancer Therapy
Rare Metals, Volume 45, Issue 4, April 2026.ABSTRACT Magnesium (Mg) alloys, as biodegradable metallic materials with excellent biocompatibility and mechanical properties, demonstrate significant advantages. In the field of immunotherapy, they present a promising potential option for enhancing therapeutic outcomes and hold broad prospects for application.
Can Feng +8 more
wiley +1 more source
Rare Metals, Volume 45, Issue 2, February 2026.ABSTRACT This study introduces novel nonequiatomic TiZrCoCrMoCux (x = 0, 5, 10; at%) medium‐entropy alloys (MEAx) tailored for orthopedic implants, synergistically combining the biocompatibility of Ti‐based alloys, the wear resistance of CoCrMo alloys, and the antibacterial/osteogenic attributes of Cu. The alloy's microstructure, mechanical properties,
Hang Yu +9 more
wiley +1 more source
Affinity Maturation of Human Immunodeficiency Virus Diagnostic Antibody [PDF]
, 2012 9E8是本实验室筛选获得的一株针对人类免疫缺陷病毒（HumanImmunodeficiencyVirus，HIV）的鼠源抗体，其亲和力为3.23×10-10M，目前已经成功应用到本实验室开发的HIV诊断试剂盒中，但其灵敏度和特异性都还有待提高。 本研究的目的就是利用噬菌体展示技术对HIV诊断抗体9E8进行亲和力成熟，进一步提高HIV诊断的灵敏度和特异性。首先，用RT-PCR的方法从杂交瘤细胞中调取鼠源抗体9E8的可变区基因，将其构建成单链抗体VH-(G4S)3-VL的形式，展示到噬菌体pIII蛋白上 ...
李善伟
core
Zhongguo shiyan zhenduanxue, 2015 目的探讨DC(dendritic cells)、CIK(cytokine-induced killer cells)联合培养对肺腺癌细胞A549的杀伤活性的影响,并与单独CIK对A549杀伤活性进行比较,为肿瘤生物治疗提供有效方法。方法分别培养DC、CIK细胞,经鉴定后进行联合培养,联合培养3天后,对A549细胞进行杀伤活性实验,检测DC联合CIK及单独CIK对A549的杀伤活性,同时用流式细胞检测DC、CIK联合培养细胞及单独CIK细胞中淋巴细胞亚群的表达。结果 ...
赵鑫 +8 more
doaj
Mechanism Analysis of TNF-α Production and Function Inhibited by Compound C2D [PDF]
, 2013 本论文在前期进行的TNF-α抑制剂筛选工作基础上，对活性单体化合物 C2D拮抗TNF-α诱导的细胞坏死的作用机理进行了初步研究。研究内容包括： 1.构建绿色荧光蛋白-TNF融合蛋白；2.在细胞水平上探讨小分子拮抗剂的作用 机制。 肿瘤坏死因子(TumorNecrosisFactor，TNF)是一类由巨噬细胞和单核细胞 分泌产生的多功能细胞因子，其中由巨噬细胞分泌的称为TNF-alpha(TNF-α)。 作为炎症反应中重要的细胞因子，TNF-α可以通过细胞膜表面受体TNFR1和 ...
刘毅
core
Is the Change of Cytokines Related to Renal Damage in Children with IgA Vasculitis？ [PDF]
, 2022 BackgroundThe long-term prognosis of IgA vasculitis (IgAV) depends on thedegreeof renal damage. Studies on the pathogenesis of renal injury in IgAV have found that cytokines play an important role in mediating and driving the process of renal damage ...
WANG Mengdi, DU Yue
core +1 more source
Zhongguo shiyan zhenduanxue, 2005 目的研究抗原冲击致敏的脐血树突状细胞体外对肿瘤细胞的杀伤作用。方法采用GM-CSF、IL-4、TNF-α联合诱导脐血树突状细胞、再用肿瘤抗原冲击致敏,测定其对肿瘤细胞的杀伤作用。结果脐血树突状细胞对NC1446、SMMC7721、K562细胞均有明显的杀伤作用。经抗原冲击致敏后,脐血树突状细胞产生明显的特异性杀伤活性。结论抗原冲击致敏的脐血树突状细胞可特异性杀伤肿瘤细胞。
任既晨, 于鸿, 王立波, 刘玉侠
doaj
The role of Rip3-mediated necrosis in system inflammatory response syndrome [PDF]
, 2016 肿瘤坏死因子-α可以诱导小鼠发生全身免疫反应综合征，其过程中发生了各组织器官的坏死和一系列级联免疫反应。在肿瘤坏死因子-α的作用下，组织细胞中的受体相互作用蛋白3被激活并募集坏死小体，导致细胞坏死，引起周围组织的炎症反应。同时，肿瘤坏死因子-α本身作为促炎因子扩大了机体免疫反应的范围。在肿瘤坏死因子-α诱导的全身免疫反应综合征中，盲肠首先表现出损伤，并且这种损伤可以被Rip3基因敲除所抑制。本论文通过建立小鼠盲肠切除术模型，与肿瘤坏死因子-α诱导全身免疫反应综合征模型并用 ...
李旸欣
core