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Zhongshan Daxue xuebao. Yixue kexue ban, 1984 T细胞在免疫监视和抗肿瘤中的重要作用已有较深入的研究。近几年来又发现天然杀伤细胞(NaturaI Killer CeII,NK细胞)不依赖抗体或补体,也不需预先致敏就能溶解多种的肿瘤细胞。因此,人们提出了NK细胞在抗肿瘤中的独特作用——免疫监视功能。动物实验发现肿瘤生长旺盛时,宿主NK细胞活性降低。在NK细胞活性高的受体内接种肿瘤,肿瘤的生长情况较在NK细胞活性低的受体内差。在人类的一些癌肿患者NK细胞活性也是低下的。提示了NK细胞的功能与肿瘤发生发展的关系。
蔡体育
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干扰素在体外对放疗后鼻咽癌病人自然杀伤细胞功能的影响 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 1984 自然杀伤(NK)细胞在体内可以抑制肿瘤的发生,发展和转移,是机体执行免疫监视功能的重要效应细胞。NK细胞对肿瘤细胞的杀伤作用受到很多因素影响和调节。最近Brovall等人报告,电离辐射在体外可以抑制人NK细胞的活性。为了解按受放疗的肿瘤病人NK细胞功能的改变,并寻找对这种变化进行调整的办法,我们进行了干扰素对放疗后鼻咽癌病人NK细胞功能影响的初步观察。
区大卫
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Zhongshan Daxue xuebao. Yixue kexue ban, 1992 采用单个细胞水平细胞毒方法研究比较了正常人外周血自然杀伤(NK)细胞对不同靶细胞结合与杀伤活性的差别。发现NK细胞对人胚胎成纤维细胞和低分化鼻咽癌(CNE-2)细胞的结合率明显高于对人成骨肉瘤细胞(OS-732)和PLC/PRF/5人肝癌细胞,结合并杀伤新鲜切除人肝癌细胞,而对同一病人的癌周肝细胞则无作用;在同一株CNE-2细胞中,NK多选择性地与核浆比例大的靶细胞结合。以上结果说明NK细胞在发挥自然细胞毒过程中具有一定的选择性,选择性地结合并杀伤分化差或幼稚的靶细胞。
doaj +2 more sources
International Journal of Immunogenetics, Volume 50, Issue 6, Page 299-305, December 2023., 2023 Abstract Hepatitis B virus (HBV) is responsible for various liver diseases, such as chronic hepatitis B (CHB), liver fibrosis, liver cirrhosis (LC) and hepatocellular carcinoma (HCC), which pose a significant threat to human health. An ineffective immune response to HBV can result in viral chronicity.
Hai Cheng +3 more
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Journal of Diabetes, Volume 15, Issue 11, Page 931-943, November 2023., 2023 Highlights Similar antibody response to COVID‐19 inactivated vaccine between healthy controls (HCs) and patients with type 2 diabetes mellitus (T2DM) after a booster shot vaccine within 6 months. Patients with T2DM have reduced antibody response after receiving the third dose of the COVID‐19 vaccine for more than 6 months. Both HCs and T2DM showed poor
Haolong Li +6 more
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Journal of Diabetes, Volume 15, Issue 10, Page 866-880, October 2023., 2023 Highlights Nattokinase rescued endothelial dysfunction and pericyte loss in the diabetic retina. Nattokinase attenuated diabetes‐induced retinal inflammation and neurodegeneration. High mobility group box 1 signaling was involved in nattokinase‐mediated retinal protection.
Zijing Huang +11 more
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Veterinary Dermatology, Volume 34, Issue 5, Page 425-440, October 2023., 2023 Background – While the clinical features were described recently, the histopathological characterisation of trunk‐dominant canine pemphigus foliaceus (PF) is lacking, and whether it differs from classic facial or insecticide‐triggered PF is unknown. Hypothesis/Objectives – This study describes the histopathological findings of trunk‐dominant PF, and ...
Natalie Katharina Yvonne Gedon +6 more
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Journal of Diabetes, Volume 15, Issue 7, Page 607-621, July 2023., 2023 Highlights The CD4 T cells of type 1 diabetes (T1D) patients particularly having HLA‐DRB1*03‐DQA1*05‐DQB1*02 haplotype are reactive against a particular region of the glutamic acid decarboxylase (GAD65) protein. GAD65 peptides encompassing 288–308 amino acid positions (peptide pool 2) may be favored by the HLA‐DR3 molecule for presentation to CD4 T ...
Neihenuo Chuzho +7 more
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Combination and integration to redirect NK cells for cancer immunotherapy [PDF]
, 2021 Cancer is a disease with still a high mortality. The number of new cases is still increasing globally despite current treatments. Therefore, new therapies with high specificity and efficiency to control the progress of cancer are urgently needed in the ...
Gong, Ying
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Enhancement of Innate Immune Function in Mice by Bifidobacterium bifidum FL-228.1 [PDF]
, 2023 In this study, eight potential functional strains were selected to interfered with RAW264.7 murine macrophages and human peripheral blood mononuclear cells (PBMCs).
Huaxi YI +8 more
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