Results 1 to 10 of about 29,794 (132)
[Causal relationship between circulating cytokines and keloids: A Mendelian randomized study]. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban目的 瘢痕疙瘩是一种以异常纤维化和高复发率为特征的皮肤纤维增生性疾病，其发生和发展与炎症介质密切相关。然而，现有流行病学研究受限于混杂因素和反向因果干扰，难以明确二者的因果关系。因此本研究采用孟德尔随机化(Mendelian randomization，MR)分析研究循环细胞因子与瘢痕疙瘩的因果关系。 方法 从全基因组关联研究(genome-wide association study，GWAS)数据中提取与瘢痕疙瘩(结局)显著相关的循环细胞因子(暴露)单核苷酸多态性(single nucleotide
Chen X, Deng K, Zhou J, Liu C.
europepmc +2 more sources
[Clinical study of the cytokine panel in the diagnosis of ocular chronic graft-versus-host disease]. [PDF]
Zhonghua Xue Ye Xue Za Zhi目的 探索细胞因子与眼部慢性移植物抗宿主病（cGVHD）的相关性，筛选眼部cGVHD的特异性生物标志物。 方法 通过建立小鼠cGVHD模型，探讨cGVHD与血清细胞因子相关性。根据动物实验结果和文献检索，确定了16种细胞因子组合，使用酶联免疫吸附试验（ELISA）比较从2017年6月至2022年3月在陆军军医大学新桥医院血液病医学中心接受异基因造血干细胞移植后发生眼部cGVHD和未发生眼部cGVHD患者的血清与泪液细胞因子表达水平。 结果 ①与对照组比较，cGVHD小鼠血清IL-1β、IL-6、IL-8、
Cheng XJ +8 more
europepmc +2 more sources
脂肪来源间充质干细胞调控原发免疫性血小板减少症小鼠Th细胞因子失衡
Zhongshan Daxue xuebao. Yixue kexue ban, 2022 目的探讨脂肪来源的间充质干细胞（AMSCs）对原发免疫性血小板减少症（ITP）小鼠Th细胞因子失衡免疫调节变化及其特异性转录因子T盒子转录因子/ GATA结合蛋白3（T-bet/GATA-3）的影响，并初步探讨其相关机制。方法选取人来源健康脂肪组织，分离培养AMSCs，观察生长形态和干细胞鉴定，选取增长稳定的传代AMSCs；将30只BALB/c小鼠随机分为正常对照组（Normal组）、ITP对照组（ITP/PBS组）及ITP实验组（ITP/AMSC组）并进行相应的处理 ...
肖建红, 张阳春
doaj
Rare Metals, Volume 45, Issue 7, July 2026.ABSTRACT Biodegradable zinc (Zn)‐based materials are considered promising candidates for orthopedic applications because of their favorable mechanical properties, controllable biodegradability, and good biosafety profiles. However, their clinical translation is limited by early‐stage corrosion‐induced cytotoxicity and inflammation, as well as ...
Jinlong Mao +9 more
wiley +1 more source
Rare Metals, Volume 45, Issue 7, July 2026.ABSTRACT Deep skin infections and dense biofilm barriers caused by Propionibacterium acnes (P. acnes) remain significant challenges in recurrent acne vulgaris, exacerbated by the poor stratum corneum penetration of conventional therapies and rising antibiotic resistance.
Bingran Qi +3 more
wiley +1 more source
Integrative Conservation, Volume 5, Issue 2, Page 192-204, June 2026.We developed an effective ex‐situ conservation approach for an endangered orchid species, Dendrobium sinominutiflorum. A compatible fungal strain Tulasnella sp. was obtained by using in‐situ seed baiting technique. The Symbiotic germination with Tulasnella sp. significantly promotes seed germination and seedling growth.
Han‐Xiao Huang +6 more
wiley +1 more source
Rare Metals, Volume 45, Issue 6, June 2026.ABSTRACT Bone restoration is often hindered by the spatiotemporal dysregulation of immune and regenerative signals. Conventional bio‐inert implants, providing only passive support, fail to modulate this microenvironment, leading to infections and poor healing.
Zhizhong Sun +8 more
wiley +1 more source
Rare Metals, Volume 45, Issue 6, June 2026.ABSTRACT Lung cancer is one of the most common and deadly malignancies worldwide. Although immune checkpoint inhibitors, including PD‐1/PD‐L1 blockers, have benefited a subset of patients, response rates remain limited, and recurrence is frequent because of the immunosuppressive tumor microenvironment (TME), characterized by hypoxia and dysregulated ...
Yi Ma +6 more
wiley +1 more source
TPCA-1对脂多糖诱导的角膜基质成纤维细胞作用及其机制的研究
Zhongguo shiyan zhenduanxue, 2014 通过研究TPCA-1影响LPS刺激角膜基质成纤维细胞分泌炎性细胞因子(IL-1,TNF-α,IL-6)和趋化因子(IL-8)以及细胞表面ICAM-1中的作用,旨在观察TPCA-1对脂多糖诱导的角膜基质细胞分泌炎性细胞因子、趋化因子 ...
姜宏, 仲炜, 闫东君
doaj
Rare Metals, Volume 45, Issue 6, June 2026.ABSTRACT The poor soft tissue integration around titanium implants creates a microgap that serves as a pathway for pathogen invasion, resulting in infection, inflammation, and the progression of peri‐implantitis. As the implant’s transmucosal component, the abutment determines the degree of peri‐implant soft tissue attachment.
Xuan Li +7 more
wiley +1 more source