Results 21 to 30 of about 19,528 (165)

Guard‐cell expression of abscisic acid receptors for engineering water‐use‐efficient plants without trade‐offs in growth

open access: yesNew Phytologist, Volume 248, Issue 2, Page 690-705, October 2025.
Summary Abscisic acid (ABA) induces stomatal closure, reducing transpirational water loss, a critical adaptation for agriculture under drought. However, ABA is often viewed cautiously as stomatal closure limits CO2 uptake for photosynthesis and growth.
Jinghui Liu   +4 more
wiley   +1 more source

纳米粒子载体胶质细胞源性神经营养因子在胶质瘤细胞中的表达与作用实验研究

open access: yesZhongguo shiyan zhenduanxue, 2007
目的观察壳聚糖纳米粒子载体载基因在胶质瘤细胞中表达及其对神经细胞的保护作用。方法采用免疫细胞化学检测胶质细胞源性神经营养因子(GDNF)在胶质细胞瘤细胞中的表达,采用细胞增殖实验(MTT法)观察GDNF对神经细胞的营养作用。结果GDNF在胶质细胞瘤细胞中有表达,在应用纳米粒子载体载基因进入细胞内后GDNF得到高效表达,并保护神经细胞,促进细胞增殖。结论应用纳米粒子载体载基因进入细胞内后可有效提高GDNF表达,并保护神经细胞,促进细胞增殖。对脊髓损伤后应用这一方法治疗提供理论依据。
刘钦毅   +3 more
doaj  

pJAK2 polypeptide,an antagonist of suppressors of cytokine signaling-1,can enhance the antitumor effect of dendritic cells [PDF]

open access: yes, 2013
目的:探讨细胞因子信号转导抑制因子-1(SuPPrESSOrS Of CyTOkInE SIgnAlIng1,SOCS1)拮抗物PJAk2多肽(氨基酸序列号为1001-1013)参与树突状细胞(dEndrITIC CEllS,dCS)的体外诱导培养后对dCS抗肿瘤作用的影响。方法:采集健康人外周血,离心获得单个核细胞,用重组人粒细胞巨噬细胞集落刺激因子(rECOMbInAnT HuMAn grAnulOCyTE-MACrOPHAgE COlOny STIMulATIng fACTOr,rHgM-CSf ...
丁园   +8 more
core  

Effect of a ceruminolytic ear cleaner on clinical, microbiological and ear canal microbiome evolution in canine erythemato‐ceruminous otitis externa associated with proliferation of Malassezia yeasts

open access: yesVeterinary Dermatology, Volume 36, Issue 5, Page 668-678, October 2025.
Background – Erythemato‐ceruminous otitis externa (ECOE) is commonly associated with Malassezia spp. and microbial imbalance. Hypothesis/Objective – To assess the clinical performance of an ear cleaner in dogs suffering from ECOE associated with Malassezia spp. overgrowth and to measure its impact on the microbiota. Conclusions and Clinical Relevance –
Amaury Briand   +11 more
wiley   +1 more source

寻常型银屑病患者血清Lipocalin-2检测水平及与疾病活动性、炎症标志物、代谢指标的关系

open access: yesZhongguo shiyan zhenduanxue, 2021
寻常型银屑病是一种具有特征性皮损的慢性炎症性皮肤病,易复发,其病理机制尚不完全清楚,多认为T淋巴细胞介导的免疫炎症反应是其发病的重要因素[1]。研究表明,寻常型银屑病患者外周血T淋巴细胞表现为增殖活性增强,活化的T淋巴细胞通过细胞表面粘附因子浸润真皮,真皮层浸润的T淋巴细胞通过释放干扰素,诱导表皮细胞合成肿瘤坏死因子α(TNF-α)及白细胞介素(IL)等细胞因子,导致表皮中性粒细胞浸润,而引起皮肤炎症[2]。
运蓓蕾, 林伟, 刘悦
doaj  

Effects of Treponema pallidum on THP-1 derived macrophage polarization [PDF]

open access: yes, 2015
梅毒螺旋体(Treponemapallidum)是性传播疾病梅毒的致病菌,尽管有关T.pallidum的研究已经开展近一个多世纪,对其生物学及病原学特性有了一定的了解,然而对于T.pallidum致病机制的认识还处于起步阶段。巨噬细胞作为机体防御外来病原体的第一道防线,在对T.pallidum的识别、吞噬、抗原提呈、杀伤等方面均发挥着重要作用。随着对巨噬细胞研究不断深入,有学者将巨噬细胞分为两种不同的极化类型,即促进炎症发展的M1型巨噬细胞和在抑制炎症反应及组织修复等方面发挥作用的M2型巨噬细胞 ...
席亚
core  

Historical and Cultural Legacy of Post‐One Child Policy: Is China Ready to Embrace Planned Oocyte Cryopreservation?

open access: yesWorld Medical &Health Policy, Volume 17, Issue 3, Page 580-588, September 2025.
ABSTRACT Women's reproductive rights in China are shaped by geopolitical and cultural factors, resulting in restricted access to planned oocyte cryopreservation (planned OC). While the global discourse surrounding planned OC continues to evolve, China currently sanctions egg freezing for medical purposes exclusively in married women, while prohibiting ...
Olivia M. Y. Ngan   +2 more
wiley   +1 more source

结核多肽特异性细胞内因子多色流式分析

open access: yesZhongguo shiyan zhenduanxue, 2013
目的建立能同时检测CD3、CD4、CD8表型及胞内因子IFN-γ、IL-4、TNF-α的多色胞内细胞因子染色流式细胞术;评价六条结核特异性多肽的性能。方法将结核患者组及健康对照组的PBMC,用结核特异性多肽或PMA刺激培养后,通过胞内细胞因子流式检测术,收集荧光标记阳性的淋巴细胞等;从而确定各亚群IFN-γ、IL-4、TNF-α阳性细胞的数量及百分率,得出两组间及各多肽间的性能差异。结果 1.各多肽均能刺激活化结核患者PB-MC产生IFN-γ等细胞因子,但百分率较低;IFN-γ及IL-4多数小于1 ...
詹能勇   +7 more
doaj  

Novel Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia [PDF]

open access: yes, 2016
缺血乏氧是肿瘤微环境的重要特征之一,肿瘤的缺血乏氧不仅促进了肿瘤细胞的侵袭转移,同时还增强肿瘤对化疗药物的耐药性。肿瘤相关巨噬细胞(Tumor-associatedmacrophages,TAMs)浸润在肿瘤微环境之中,通常在肿瘤缺血乏氧区域富集。肿瘤相关巨噬细胞作为肿瘤微环境的重要功能细胞,其在肿瘤细胞的增殖、侵袭、转移、化疗耐药等肿瘤进展的各个阶段均发挥着重要作用。鉴于此,我们提出一种新型的肿瘤治疗策略,以期改变肿瘤微环境的同时,增强实体瘤对化学治疗的疗效 ...
宋曼莉
core  

Arsenic Trioxide Induces T cell Apoptosis and Prolongs Islet Allograft Survival in Mice [PDF]

open access: yes, 2015
目的:作为一种最有潜力的I型糖尿病的治疗方法,胰岛移植目前已经应用于临床。然而,免疫因素特别是T细胞介导的移植物活性损伤与功能丧失是胰岛移植应用的一大障碍。一直以来,科学家们都在寻找适用于胰岛移植的新型免疫抑制剂。三氧化二砷是临床上治疗早幼粒细胞白血病的特效药,最近被证明能够抑制同种异体心脏移植排斥反应。在此基础上,本文研究了三氧化二砷对同种异体胰岛移植免疫排斥的抑制作用,以及三氧化二砷与雷帕霉素联合诱导免疫耐受的可能作用机制。 方法:我们首先检测了三氧化二砷对胰岛细胞的毒性作用 ...
高畅
core   +1 more source

Home - About - Disclaimer - Privacy