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Journal of Diabetes, Volume 12, Issue 9, Page 649-658, September 2020., 2020 Highlights Coronavirus disease 2019 (COVID‐19) is caused by SARS‐CoV‐2; recent modeling of the structure of SARS‐CoV‐2 spike glycoprotein, which mediates viral‐host‐cell entry, predicts interactions with dipeptidyl peptidase 4 (DPP4) in addition to angiotensin‐converting enzyme 2.
Margaret F. Bassendine +3 more
wiley +1 more source
Research on T Lymphocyte Subsets and NK Cells Activity in Peripheral Blood of Hypopharyngeal Squamous Cell Carcinoma [PDF]
, 2017 目的:分析下咽鳞状细胞癌患者外周血T淋巴细胞亚群和NK细胞活性情况,旨在为相关研究工作提供参考资料。方法:择取2011年6月-2016年5月本院收治的95例下咽鳞状细胞癌病患为病例组,另取此期间内来本院接受健康检查的72例志愿者为正常组。使用流式细胞仪对病患开展相关检查,分析病例组与正常组的淋巴细胞亚群、NK活性情况以及不同临床分期的下咽癌病患外周血T淋巴细胞亚群以及NK细胞活性之间的关系。结果:与正常组相比,病例组的NK细胞、总B淋巴细胞、总T淋巴细胞、辅助/抑制T细胞、辅助T细胞偏低(P0.05 ...
刘存山 +7 more
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Recent advances and prospect in immune microenvironment and its mechanisms of function in head and neck squamous cell carcinoma [PDF]
, 2023 Head and neck cancer (HNC) remains a significant cause of morbidity and mortality. The most prevalent pathology among HNC is head and neck squamous cell carcinoma (HNSCC).
ZHANG Shaoqiu, YAN Li, LI Ruichen, ZHAO Yang, WANG Xiaoshen, YANG Xuguang, ZHU Yi
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Zhongshan Daxue xuebao. Yixue kexue ban, 2023 自然杀伤（NK）细胞是T细胞后具有临床应用前景的另一类抗肿瘤免疫细胞。NK 细胞的活性主要受其表面受体和免疫微环境的调控，胶质瘤较强的免疫抑制性肿瘤微环境使NK细胞免疫治疗效率较低。本综述从胶质瘤-NK细胞交互作用角度讨论NK细胞在脑胶质瘤免疫治疗中作用的最新研究进展，总结靶向NK 细胞的化合物、单克隆抗体和细胞因子疗法，重点讨论了基因修饰的NK细胞在胶质瘤免疫治疗的现状及趋势，以及胶质瘤细胞的相关免疫逃逸分子机制，为基于NK细胞的免疫治疗神经胶质瘤提供理论依据和新的思路。
孙士隆, 陈保东
doaj
Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929 [PDF]
, 2015 Clnk/MIST在一系列细胞因子依赖的造血细胞系中表达，同时也在一些细胞因子非依赖的肥大细胞系中表达，并且能够与PLC，Grb2，ADAP和HPK-1等蛋白相互作用。 作为Blnk/SLP-76接头分子蛋白家族的第三个成员，Clnk参与免疫受体信号通路的正向调控。但是，在Clnk基因敲除鼠中，Clnk对T细胞，NK细胞和肥大细胞的正常分化和发育并不是必须的。 本论文发现了Clnk在免疫信号通路之外的一些功能。我们发现Clnk在一系列细胞因子非依赖的非造血细胞系中表达，比如L929 ...
徐盟
core +1 more source
Research Progress on Immunomodulatory Activity of Polysaccharides from Blue Foods [PDF]
, 2023 With the current over-exploitation of terrestrial resources, multi-dimensional in-depth utilization of aquatic resources has attracted widespread attention.
GU Fudie, ZHOU Yu, CHEN Huiying, LIU Wenmei, ZOU Zehua, LIU Guangming, LIU Qingmei
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Current status and treatment direction of the immune microenvironment of castration-resistant prostate cancer [PDF]
, 2023 With the rapid development of cancer immunology, more and more research focuses on the role of immune cells and signaling molecules in the tumor microenvironment. Prostate cancer is the second most common malignant tumor in men globally.
YANG Wenbo, ZHANG Bin, WU Jiahui, CUI Jie
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Effects of Chinese Medicine of Fuyang Detoxification on Cellular Immune Function in Breast Cancer Undergoing Neoadjuvant Chemotherapy [PDF]
, 2017 目的研究与分析中药扶阳清毒治疗对乳腺癌新辅助化疗患者细胞免疫功能的具体影响。方法方便选取该院自2014年3月—2017年3月收治的乳腺癌初治患者68例,按照随机数字表法将其随机分为单一治疗组与联合治疗组,每组34例,予以单一治疗组患者单纯新辅助化疗治疗,予以联合治疗组患者新辅助化疗联合中药扶阳清毒法治疗,另选取该院同一时期收治的乳腺纤维瘤患者34例患者做为对照组,对单一治疗组及联合治疗组两组患者治疗前后细胞免疫功能变化进行观察与对比。结果单一治疗组患者与联合治疗患者组两组治疗前的CD3、CD4 ...
许浩云, 黄献钟
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The Oncologist, Volume 24, Issue 11, Page e1055-e1069, November 2019., 2019 Abstract In the light of recent advances in the immunotherapy field for breast cancer (BC) treatment, especially in the triple‐negative subtype, the identification of reliable biomarkers capable of improving patient selection is paramount, because only a portion of patients seem to derive benefit from this appealing treatment strategy. In this context,
Federica Miglietta +3 more
wiley +1 more source
The effect and mechanism of IL-1 R II / IL-1 RAcp in Autoimmune Myocarditis [PDF]
, 2016 【目的】白介素-1（IL-1）是一种T淋巴细胞激活因子，大量研究报道，在心肌炎急性期表达量明显升高。白介素1受体II型（IL-1RII）可以招募白介素1受体辅助蛋白（IL-1RAcp），从而拮抗IL-1β的作用。本课题目的为评估IL-1RII和IL-1RAcp的重组质粒对大鼠自身免疫性心肌炎（EAM）的作用，并进一步探讨其机制，为心肌炎的临床治疗提供理论基础。 【方法】首先在临床实验中，我们选取厦门市心血管病医院诊断明确的心肌炎住院患者28例，应用bio ...
宋颖
core