Results 1 to 10 of about 27,949 (148)
Aurora-A/STK15/BTAK overexpression induces centrosome amplification, chromosomal instability, and transformation in human urothelial cells [PDF]
, 2007 Aurora-A/STK15/BTAK kinase encoding gene, located on chromosome 20q13, is frequently amplified and overexpressed in human cancers. Sen et al. previously demonstrated that Aurora-A amplification and overexpression are associated with aneuploidy and ...
Anand S, Penrhyn-Lowe S and Venkita +13 more
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The role of jumping translocation breakpoint gene promoting instability of genome and the biological function of its protein and potential clinical value [PDF]
, 2014 染色体不稳定性是大多数肿瘤细胞特别是实体瘤细胞和体外转化细胞的基本特征。其表现形式包括整条染色体的获得或缺失，杂合缺失，染色体易位重排，基因扩增等。目前认为染色体不稳定是肿瘤形成的始发因素，出现在肿瘤进展的早期阶段。体内外各种损伤刺激导致的基因组DNA链的断裂是染色体不稳定的根本原因。我们的研究发现，跳跃易位断裂点基因（JTB）在胃癌、肝癌中存在广泛的基因扩增和基因易位行为，而基因的扩增和易位是DNA双链断裂后异常修复的最终结果。JTB基因的断裂易位将导致其编码跨膜结构域的基因序列丢失 ...
刘贇鹏
core
異数体を含むレンゲ人為同質４倍体集団での全兄弟と半兄弟の共分散の計算 [PDF]
, 2008 Full and half sib covariances were investigated in an artificial autotetraploid population with random mating in Astragalus sinicus L.. Since a set of homologous chromosomes is not necessarily involved in aneuploidy, the covariances must be averaged for ...
Kato, Kenji, Morisawa, Tetsuo
core
Evolutionary algorithms in dynamic environments [PDF]
, 2006 The file attached to this record is the author's final peer reviewed version.Evolutionary algorithms (EAs) are widely and often used for solving stationary optimization problems where the fitness landscape or objective function does not change during the
Wang, Dingwei +2 more
core
人為同質４倍体集団における全兄弟及び半兄弟共分散の数学モデル [PDF]
, 2008 For the estimation of genetic variance of an artificial autotetraploid population, a mathematical model of full and half sib covariances between sibs with various chromosome numbers, which were derived from euploid or aneuploid parents, was devised for a
Kato, Kenji, Morisawa, Tetsuo
core
Karyotype analysis of diploid oat germplasm introduced from Canada [PDF]
, 2014 The chromosome karyotype of three diploid oat species was studied with squash method. The results showed that the karyotype formula of Avena strigosa was 2 n =2 x = 14 = 10 m + 4 sm(2SAT),with metacentric and submetacentric chromosomes,1 pair of ...
Liu, W., Wu, B., Zhang, Z.
core
野生动物学报, 2014 采用常规骨髓细胞制片法,对分布在新疆哈巴河地区捷蜥蜴(Lacerta agilis)种群的染色体组型进行了研究。结果表明,捷蜥蜴的二倍体染色体数为38条,性别决定机制为ZW型,存在异型的性染色体,其中,雄性性染色体为ZZ型,染色体组型为2n=34I+2m+ZZ; 雌性性染色体为ZW型,染色体组型为2n=34I+2m+ZW。捷蜥蜴的染色体除第18对和W染色体呈点状外,其余全部为端着丝点染色体。按照染色体的相对长度将18对常染色体分成3组,第1组包括第1、2、3对染色体(相对长度>7.5%),第2组包括第4～
张德成 赵文阁 刘 鹏
doaj
A preliminary study on mechanisms of fission yeast Dnt1 participating in accurate chromosome segregation and efficient G2/M transition [PDF]
, 2016 在裂殖酵母中，Dnt1主要定位在核仁里，在有丝分裂后期还定位在纺锤体上。本实验室之前的研究发现，Dnt1对于纺锤体检验点的沉默是必需的；另外Dnt1通过下调Wee1蛋白水平调控细胞G2/M转换以及胞质分裂。 本研究通过对染色体分离情况的精确观察，我们发现Dnt1与Monopolin蛋白(Pcs1/Mde4)、AuroraB激酶Ark1分别通过不同途径防止姊妹染色体的merotelicorientation，在染色体准确分离过程中起着重要作用。利用nda3-KM311cdc13-GFPark1 ...
陈丽华
core
野生动物学报, 1996 本文报道了我国北方一种主要的农田害鼠，黑线仓鼠（ＣｒｉｃｅｔｕｌｕｓｂａｒａｂｅｎｓｉｓｆｕｍａｃａｓＴｈｏｍａｓ）的染色体核型，染色体标本采用骨髓细胞材料，按秋水仙素──低渗──空气干燥法制成。黑线仓鼠二倍体细胞的染色体数为２ｎ＝２４，常染色体臂数Ｍ＝２０，Ｘ染色体为中部着丝粒染色体 ...
王俊森 +5 more
doaj
Zhongguo shiyan zhenduanxue, 2022 目的 探讨孕早期B超影像异常与胎儿绒毛染色体异常核型及多态变异关系。方法 对2016年11月至2018年5月到玉林市妇幼保健院就诊孕早期B超影像诊断胎儿异常，孕妇自愿行绒毛产前诊断82例绒毛染色体回顾统计分析。结果 孕早期B超影像异常82例行绒毛染色体培养，培养成功79例，培养成功率96.34%。培养成功79例绒毛染色体核型中，胎儿绒毛染色体异常核型及多态变异检出率，21-三体为11.39%,18-三体为10.13%，特纳综合症为8.86%，嵌合体为3.80%,13-三体为3.80%，易位为2.53 ...
邓国生
doaj