Research Progress in Short-Chain Fatty Acid Modulation of the Gut-Bone Axis in Bone Metabolism [PDF]
As global aging intensifies, the incidence of age-related bone metabolic disorders, such as osteoporosis, continues to climb. Seeking safe and effective therapeutic interventions is of utmost importance.
ZHANG Xuan, YANG Xue, LI Xinke, MENG Lu, WANG Jiaqi, ZHENG Nan
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Application of Gut Microbiota Research Models and Omics Techniques to the Risk Assessment of Chemical Hazards in Foods [PDF]
Chemical hazards in foods have become a global public health challenge with the widespread use of chemicals in food processing. Currently, the effects of chemical exposure on human health are usually assessed by relying on complex and invasive assays for
ZHAI Qixiao, YIN Pingping, WANG Shumin
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[Trimethylamine N-Oxide Induces Renal Fibrosis Through the PI3K/AKT/SREBP1 Pathway]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue Ban, 2023 Chen J, Huang Y, Zhao J.
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, 2007 对NMR波谱数据的统计分析是基于NMR代谢组学研究的关键问题之一.鉴于NMR波谱信号可以近似为样品中各种成分谱信号的线性叠加,本文将非负矩阵分解(NMF)方法引入基于NMR代谢组学的数据处理中,并与代谢组学中常用的统计方法——主成分分析(PCA)进行比较.通过NMF和PCA两种方法对健康志愿者与2型糖尿患者血液和尿液的NMR谱图的统计分析,对所获取的特征代谢物进行比较和验证,并探讨了PCA方法可能存在的不足之处及其原因;阐明了NMF方法是基于NMR的代谢组学研究中较理想的数据分析方法.最后 ...
徐乐 +6 more
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[Correlation Between Plasma Trimethylamine N-Oxide and Lipid Levels in Hyperlipidemic Patients]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue Ban, 2023 Fei'erdun T +4 more
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Research Progress on the Interaction between Taurine Metabolism and the Gut Microbiota [PDF]
Taurine is a non-essential sulfur-containing amino acid that is widely distributed in the human body, primarily supplemented through the diet. Taurine can combine with bile acids to form taurine-conjugated bile acids (Tau-Bas), which can be dissociated ...
YANG Xinyu, WU Qingjie, MI Shengquan, ZHANG Yanzhen, GUO Junxia
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Trimethylamine oxide induces pyroptosis of vascular endothelial cells through ALDH2/ROS/NLRP3/GSDMD pathway. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2022 Li J +5 more
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Advances in Understanding the Nutritional Value and Digestive Characteristics of Plant-Based Meat [PDF]
With the continuous growth of the global population and the increasing disparity between food supply and demand, the rising demand for meat consumption has placed additional pressure on the environmental protection of agricultural resources.
LIN Yao, PENG Yu, HAN Qiuyu, JIANG Yuanxue, ZHAO Jing
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Zhongshan Daxue xuebao. Yixue kexue ban, 2012 【目的】 评价改良化学方法制备脱细胞神经支架的去髓鞘与脱细胞效果。【方法】 12只成年SD大鼠(230~280g),取双侧坐骨神经,随机分为3组,每组8例,分别采用不同的处理方法。正常对照组:不作任何处理;Hudson组:采用Triton X-200、磺基三甲铵乙内酯-10(SB-10)、磺基三甲铵乙内酯-16(SB-16)处理;改良组:采用Triton X-200、SB-10、SB-16联合脱氧胆酸钠(SDC)及过氧乙酸(PAA)处理,处理后行HE染色、甲苯胺蓝染色及透射电镜检查,观察脱细胞 ...
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肠道菌群代谢物TMAO对兔动脉粥样硬化斑块形成及狭窄程度的影响
Zhongguo shiyan zhenduanxue目的 探讨氧化三甲胺(Trimetlylamine oxide, TMAO)在兔动脉粥样硬化斑块产生及狭窄程度中的作用。方法 3月龄新西兰雄性白兔32只，随机分为对照组、模型组、TMAO组和TMAO抑制组，每组8只。对照组给予普通饲料喂养，余各组给予高脂饮食。喂养1周后，模型组给予高脂饮食+低温气体损伤兔颈动脉内膜建立动脉粥样硬化斑块模型；TMAO组操作同模型组，并给予氯化胆碱灌胃；TMAO抑制组操作同TMAO组，但饮水中加入TMAO抑制剂3,3-二甲基-1-丁醇(DMB)。术后12周再次检测血脂 ...
路怀志, 池尧, 赵辉, 许学升
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