Results 21 to 30 of about 2,514 (103)
Zhongguo shiyan zhenduanxue, 2020 氧化三甲胺(TMAO)是在人体摄入富含胆碱、左旋肉碱、卵磷脂等高脂营养物质后经肠道微生物转化后生成三甲胺(TMA),而后在肝脏的作用下生成的一种小分子化合物[1]。有相关研究表明,心血管疾病及不良心血管事件的发生与TMAO的产生、代谢过程相关,因此TMAO或可作心血管疾病诊断及治疗的潜在靶点[2,3]。本文就TMAO的生物学特性及其与心血管疾病的联系进行综述。
吴箴言 +5 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 2023 目的为了解肿瘤医院院感情况及其变化趋势，探讨肿瘤专科医院感染防控重点策略。方法通过医院感染监测系统获取中山大学肿瘤防治中心2019~2021年医院感染质量控制指标数据，采用卡方检验和趋势卡方检验对指标变化进行分析。结果2019~2021年该院院感发生率分别为0.80%、0.78%和0.57%，逐年显著下降（P<0.001）。其中以手术部位和呼吸系统感染较常见，两部位占比分别是35.75%和31.08%。革兰阴性菌和真菌是主要病原体。多重耐药菌院感发生率逐年显著上升，从0.08‰上升至0.14‰（P&
黄丽华 +6 more
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Mechanism of Trimethylaminc-N-Oxide-Induced Human Umbilical Vein Endothelial Cell Damage by 5-Heptadecylresorcinol(十七烷基间苯二酚对氧化三甲胺诱导的人脐静脉内皮细胞损伤的作用机制) [PDF]
Shipin kexue jishu xuebaoTo investigate the anti-atherosclerosis effect and mechanism of 5-heptadecylresorcinol (AR-C17), a bioactive substance in whole grain foods, human umbilical vein endothelial cells (HUVEC) were induced with trimethylamine-N-oxide (TMAO) to establish ...
YANG Zihui(杨子慧) +5 more
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Zhongguo shiyan zhenduanxue, 2020 纤维化指各种有害刺激造成组织损伤后启动的修复机制,表现为过度、无序的间质内纤维结缔组织大量增生、细胞外基质增多、实质细胞减少,严重可致器官结构破坏和功能减退。探讨纤维化的发生机制对于有效延缓器官功能减退至关重要。研究表明,肠道源性毒素氧化三甲胺(TMAO)在器官纤维化进程中扮演着重要角色。基于目前最新研究,本文就肠道源性毒素TMAO与心肌纤维化、肾脏纤维化的关系及机制进行综述。
谢舜昀, 刘师辰, 李微, 崔文鹏
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Impact of Choline Intestinal Metabolism on Gut Microbiota and Physiological Indicators of Host Homeostasis [PDF]
This study aimed to investigate the changes in trimethylamine (TMA) levels in cecal contents, intestinal microflora structure and physiological homeostasis indicators in mice receiving dietary supplementation of choline, dietary supplementation of ...
SONG Yu, WU Di, ZHANG Lu, WANG Ting, ZHANG Min, LI Qian
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--1H-NMR Spectroscopy-based Metabonomic Research on Serum of Model Rats of Wilson's Disease [PDF]
, 2010 目的:以基于核磁共振(nMr)的代谢组学方法对WIlSOn病大鼠模型及正常对照组大鼠血清进行研究,分析血清中小分子代谢物的变化,从小分子代谢物层面上探讨WIlSOn病的内在机制,以更加清楚的认识本病。方法:22只雄性WISTAr大鼠,体重(180±20)g,随机被分为模型组(n=11)和健康对照组(n=11),采用铜负荷法制作WIlSOn病大鼠模型,以核磁共振(nMr)技术对大鼠血清进行检测。采用MESTrE-C 2.3软件及自编软件对谱图进行手动调相、基线校正和谱峰对齐。对样品进行分段积分 ...
刘兰林 +5 more
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浙江大学学报. 农业与生命科学版Biodrying-enhanced composting (BEC) technology solves the bottleneck problems of slow microbial enrichment and a long composting cycle in traditional aerobic composting and has broad application prospects.
ZHANG Qihang(张启杭) +3 more
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NMR-based Metabonomics Study of Patients with Cerebral Infraction Complication in Type 2 Diabetes Mellitus [PDF]
, 2013 目的应用氢谱核磁共振代谢组学(1H-nMr)方法研究2型糖尿病(T2dM)合并脑梗死患者血清中小分子代谢物代谢轮廓的变化,探讨2型糖尿病合并脑梗死的可能发病机制。方法选择T2dM合并脑梗死患者19例、单纯T2dM患者25例及健康对照者29例,利用1H-nMr方法检测血清的代谢轮廓,通过偏最小二乘判别分析方法,鉴别各组别间血清小分子代谢物的区别。结果从血清偏最小二乘判别分析得分图中可以区分3组患者,与T2dM合并脑梗死有关的特征代谢物包括极低密度脂蛋白、低密度脂蛋白、葡萄糖、乳酸、丙酮酸、3-羟基丁酸、n-
杨香玖 +4 more
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“Subtype-precise” therapy leads diagnostic and therapeutic innovations: a new pattern for precision treatment of breast cancer [PDF]
Breast cancer is the most common malignant tumor among women worldwide, with incidence rates rising annually. The treatment of breast cancer has undergone significant transformations, evolving from an initial reliance on a single surgical approach to the
ZHANG Siwei, MA Ding, JIANG Yizhou, SHAO Zhimin
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中西医结合护理This article summarizes the nursing experience of a patient with nausea and vomiting after paclitaxel liposome chemotherapy treated by acupoint injection therapy combined with intravenous administration of antiemetic drugs.
LIU Fei (刘菲) +2 more
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