NMR联用HILIC-UPLC-MS/MS测定TNBS诱导的结肠炎大鼠尿液和血浆代谢物变化 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2021 目的基于非靶标和靶标代谢组学技术，探讨三硝基苯磺酸（TNBS）诱导的结肠炎模型大鼠尿液以及血浆中内源性代谢物的变化。方法16只雄性SD大鼠随机分成对照组和模型组，每组8只，对模型组大鼠给予TNBS灌肠以建立实验性大鼠结肠炎模型。利用核磁共振氢谱（1H NMR）检测两组大鼠尿液代谢物，同时联用HILIC模式超高效液相色谱串联三重四级杆质谱（HILIC-UPLC-MS/MS）测定以上大鼠尿液以及血浆中氨基酸水平，并通过多元变量统计方法对代谢组学数据进行分析。结果同对照组相比，1H ...
刘雯 +7 more
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Zhongguo cuzhong zazhi针灸作为传统医学的重要组成部分，近年来在缺血性卒中治疗中的机制受到广泛关注。本文对针灸通过干预脑-肠轴治疗缺血性卒中的相关基础研究进行汇总分析，发现其可能涉及以下机制：其一，调节肠道菌群组成，抑制致病菌增殖并促进有益菌定植，同时增强肠上皮紧密连接蛋白表达以维持肠道屏障功能，减少肠源性毒素入血；其二，通过神经内分泌调控抑制下丘脑-垂体-肾上腺轴过度激活，降低促炎因子释放，并激活迷走神经介导的抗炎通路；其三，调节短链脂肪酸、氧化三甲胺等肠道菌群代谢产物的动态平衡，改善全身炎症微环境；其四 ...
赵乾坤1，2，李宪东2，徐天策2，陈会生1，2 (ZHAO Qiankun1,2, LI Xiandong2, XU Tiance2, CHEN Huisheng1,2 )
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Generation Mechanism of Gut-Derived Trimethylamine and Its Dietary Regulation(肠源性三甲胺生成机制及其饮食调控) [PDF]
Shipin kexue jishu xuebao, 2023 Substances such as choline, L-carnitine, and betaine contained in food can be converted into trimethylamine (TMA) under the action of gut microbiota. TMA can be easily absorbed by intestinal epithelial cells, transported to the liver through the portal ...
WANG Shijie(王世杰) +1 more
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Correlation Study between Serum Trimethylamine-N-oxide and the Risk of Acute Ischemic Stroke [PDF]
, 2022 BackgroundAssessment of the risks of stroke and then initiation of primary prevention are crucial to reducing the incidence rate of stroke. Trimethylamine-N-oxide (TMAO) is a recently discovered intestinal microbial metabolite, whose relationships with ...
LUO Jiaxin, ZHANG Aoqi, GAO Ruijiang, LI Ziru, ZHU Runxiu, YAO Yuan, YUAN Jun
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Construction of Electrochemically Enhanced Detection System for Cholesterol in Foods Based on Novel Fe3O4@Au/MOF(基于新型金属有机框架模拟酶的电化学检测食品胆固醇体系的构建) [PDF]
Shipin kexue jishu xuebao, 2022 A real-time electrochemical sensor for detecting cholesterol was constructed due to the mimic enzyme characteristics of the metal organic framework (MOF).
ZHANG Yue(张悦) +5 more
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Effect of Modified Atmosphere Packaging on Changes of Formaldehyde and Quality of Dosidicus gigas Dried Squid Thread During Storage(气调包装对秘鲁鱿鱼丝储藏过程中甲醛及相关品质指标的影响) [PDF]
Shipin kexue jishu xuebao, 2017 Jumbo squid (Dosidicus gigas) dried squid thread were packaged in air, vacuum, modified atmosphere (40%CO2+60%N2), and modified atmosphere (40%CO2+60%N2) after treating with 0.5% citric acid, respectively.
LI Xuepeng(李学鹏) +8 more
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Research progress in the relationship between gut microbia and its metabolites and gestational diabetes mellitus [PDF]
, 2023 The global incidence of gestational diabetes mellitus (GDM) continues to rise in recent years. Research has shown that GDM can increase the risk of adverse pregnancy outcomes in pregnant women and lead to malignant intergenerational circulation.
FANG Zichen +5 more
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Determination of 80 Veterinary Drug Residues and Their Metabolites in Beef by HPLC-MS/MS(HPLC-MS/MS法同时测定牛肉中80种兽药及其代谢物) [PDF]
Shipin kexue jishu xuebao, 2022 In order to comprehensively investigate the risk of veterinary drug residue in beef in Ningxia, in this study, 12 types of drugs were screened and identified from three aspects:banned and stopped drugs prescribed by the Ministry of Agriculture and Rural ...
LI Yongqin(李永琴) +4 more
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Advances in the Mechanism and Regulation of Obesity Induced by Gut Microbiota [PDF]
, 2023 The global prevalence of obesity has nearly tripled in the past 40 years and continues to rise at an alarming rate. High fat and high carbohydrate diets can cause gut microbiota disturbance and impairment of intestinal barrier function in obese ...
YU Miao, XU Jinzhao, YANG Xiaoying, MA Longkai, YU Yansong, NING Ke, XIE Qinggang, XU Xiaoxi
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Advances in fundamental and translational breast cancer research in 2022 [PDF]
, 2023 According to the data released by the International Cancer Research Institute of the World Health Organization (WHO), breast cancer is the malignant tumor with the highest incidence rate in women, and seriously endangers women's health.Many impressive ...
WANG Ziyu, XIAO Yi, JIANG Yizhou, SHAO Zhimin
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