【目的】 探讨不同的代谢活化系统在人细胞转化模型中潜在的应用价值65377; 【方法】 在永生化人肝细胞L02中导入第12密码子突变的H-RAS癌基因(L02-R细胞),使其处于恶性转化前的易感状态65377;选择具有代表性的间接致癌物黄曲霉毒素B1 (aflatoxin B1, AFB1) 作用于永生化和转化前期细胞株,采用三种代谢系统:高表达代谢酶P450 CYP1A2,低剂量底物诱导和加入经典的大鼠S9代谢辅助系统,通过软琼脂克隆形成试验和裸鼠皮下成瘤试验来比较在不同的代谢活化系统下 ...
doaj
血小板在正常止血过程中十分重要 ,当血小板数量或功能发生变化时 ,机体易于发生出血或血栓。目前 ,检测血小板功能的方法日益增加 ,包括测定血小板粘附、聚集和活化的能力等。近年来随着对血小板激活机制的深入研究以及生物化学、免疫和分子生物学技术的不断发展 ...
彭黎明, 杨菁
doaj
[Bifunctional biomaterials: An innovative strategy for synergistic bone tumor therapy and bone regeneration]. [PDF]
Feng W, Chang B, Wang C, Fan B.
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[Progress in regulating stem cell functions for repair and regeneration of craniomaxillofacial tissues]. [PDF]
Zhang H, Yang F, Yang R.
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[Advances in research on the mechanisms of reactive oxygen species in platelet activation and thrombosis]. [PDF]
Shen RY, Xu KL, Qiao JL, Fu P.
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Trends of Water Gas Shift Reaction on Transition Metal Surfaces from First Principles calculation [PDF]
[[abstract]]The mechanism of water gas shift reaction (WGSR) on the close-packed transition metal surfaces of Co, Ni Cu (from the 3d row) Rh, Pd, Ag (from the 4d row) and Ir, Pt, Au (from the 5d row) has been systematically examined by periodic density ...
Huang Shih-Chang, 黃世昌
core
<正> 一、什么是燃料电池?有何优点和用途? 化学电源的种类很多,分类方法也很多。目前常用的分类方法是把它们分为四类: (1)原电池即一次电池:电池的活性物质(起化学反应而产生电能的物质,在正极为氧化剂,在负极为还原剂)装在电池内部。当活性物质消耗完后 ...
doaj
[Research progress on protein lactylation modification in malignant tumors]. [PDF]
Dong H, Chen H, Zhang C.
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[Research advances on the targeted programmed cell death regulatory network for treatment of refractory diabetic wounds]. [PDF]
Zhang ZH, He WF.
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[Research progress on the multidimensional regulation of gut microbiota on metabolism, immunity, and inflammatory response in metabolic associated fatty liver disease]. [PDF]
Wu ST, Lu XL.
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