Results 11 to 20 of about 18,233 (162)
ABCA12 Frameshift Deletion in Domestic Cats With Ichthyosis Fetalis
ABSTRACT Background Ichthyosis fetalis (IF), also known as harlequin ichthyosis, is a rare and often fatal autosomal recessive congenital skin disorder. It is characterized by thickened, hard skin plaques and deep skin fissures that limit mobility and cause malformations of the eyes, lips and ears.
Jeanna M. Blake +2 more
wiley +1 more source
ABSTRACT Background Advances in transcriptomics have driven the demand for minimally invasive, reproducible and high‐yield skin sampling methods, particularly for studying inflammatory skin diseases in companion animals. Hypothesis/Objectives We tested tolerability, feasibility and RNA quantity and quality of three minimally invasive skin sampling ...
Ina Herrmann +2 more
wiley +1 more source
ABSTRACT Objective Complete hydatidiform mole and coexisting normal fetus (CHMCF) is a rare condition for which there is significant heterogeneity in diagnosis, counseling and management of complications. The objective of this study was to summarize the prevalence of clinical outcomes in reported cases of CHMCF.
N. Salmeri +8 more
wiley +1 more source
ABSTRACT Objective To investigate whether combining abnormal morphological features observed on ultrasound in live pregnancies that ended in a first‐trimester miscarriage can predict an abnormal karyotype. Methods This retrospective observational cohort study was conducted at the early‐pregnancy assessment unit at University College London Hospital ...
T. Setty +5 more
wiley +1 more source
ABSTRACT This study applies the Narrative Policy Framework (NPF) within a non‐democratic context, exploring the role of policy narratives in the implementation of patient‐centred healthcare policy in China. Drawing on a dataset of academic journal articles that reference both “market” and “patient‐centredness,” the research reveals how local ...
Jingqing Yang
wiley +1 more source
Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis +9 more
wiley +1 more source
ABSTRACT Objective The corpus callosum (CC) is an interhemispheric structure that facilitates communication between the two cerebral hemispheres. Anomalies of the CC are frequent and associated with a wide spectrum of altered neurodevelopmental outcomes.
R. Corroenne +55 more
wiley +1 more source
Investigation of the Role and Mechanism of Rapamycin on Senile Osteoporosis via Osteocyte Autophagy [PDF]
背景:老年性骨质疏松症患病人数逐年攀升,已成为严重的公共卫生问题。最新研究表明:骨细胞通过调节成骨细胞和破骨细胞的功能,从而主导骨重建。随着年龄增长,骨细胞凋亡增加,数目减少,导致骨代谢紊乱。细胞自噬是一种重要的生理机制,可以协助维持骨细胞活性。研究表明,因年龄增加而导致的骨细胞自噬功能障碍与老年性骨质疏松症的发病密切相关。因此,本课题以骨细胞自噬为切入点,选取经典的自噬诱导剂雷帕霉素,探究其对于老年性骨质疏松症的作用及可能机制。 方法:将52只24月龄SD大鼠随机分为雷帕霉素组和对照组 ...
罗德庆
core
ABSTRACT Objectives To compare the maternal hemodynamics of Chinese women at low and at high risk for preterm pre‐eclampsia (PE) and assess the differences in hemodynamic parameters between high‐risk women with or without prophylactic aspirin. Methods This was a prospective longitudinal case–control study of 857 Chinese women with a singleton pregnancy
X. Wang +11 more
wiley +1 more source
从广东省以及海南省等地区养殖的患病罗非鱼体内分离、收集到多株致病菌,经生化分析和分子生物学鉴定,均为无乳链球菌。对这些菌株分别进行了耐药谱测定、分子分型试验以及分子血清型分析。药敏试验结果表明,2007—2010年分离到的无乳链球菌耐药谱基本相似;多位点可变数目串联重复序列分析(MLVA)试验中,选择5个高变异指数的可变数目重复位点(VNTR)进行分子分型,结果表明,所有鱼源无乳链球菌菌株为同一MLVA型,而作为对照的牛源无乳链球菌则明显不同;为了对这些菌株进一步分型 ...
张德锋 +5 more
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