Results 41 to 50 of about 22,262 (188)

2017-2019武汉地区学龄前儿童急性下呼吸道感染常见病原体流行特征分析

open access: yesZhongguo shiyan zhenduanxue, 2021
目的分析近三年武汉地区急性下呼吸道感染住院学龄前患儿的呼吸道病原体感染情况及流行特点,为临床诊疗及流行病学调查提供依据。方法收集38479例于2017年3月-2020年2月在武汉儿童医院住院部诊断为急性下呼吸道感染学龄前患儿的血清,采用间接免疫荧光法检测9种呼吸道病原体:肺炎支原体(MP)、肺炎衣原体(CP)、嗜肺军团菌血清1型(LPl)、腺病毒(ADV)、Q热立克次体(COX)、呼吸道合胞病毒(RSV)、甲型流感病毒(INFA)、乙型流感病毒(INF-B)和副流感病毒1/2/3型(PIVS)IgM抗体。
张家云, 曾叶, 王晓梅
doaj  

Correlation between Chlamydia Pneumoniae IgG Positive in Lung Cancer Patients and Cytokines Related to Radiation-induced Pulmonary Lesion [PDF]

open access: yes, 2011
Background and objective There exsits intimate relationship between infection with chlamydia pneumoniae (Cpn) and lung cancer incidence. But few studies have been reported about radiation-induced pulmonary lesion in lung cancer patients infected with Cpn.
Daoan ZHOU   +3 more
core  

2013年长春市儿童医院HFMD患儿病原特点分析

open access: yesZhongguo shiyan zhenduanxue, 2016
目的分析2013年长春市儿童医院住院手足口病(HFMD)患儿病原学特点,了解住院HFMD患儿病原的变化。方法分析2013年长春市儿童医院住院的1111例HFMD患儿一般情况;应用荧光定量PCR方法检出粪便肠道病毒通用型(EV)、新型肠道病毒71型(EV71)、柯萨奇病毒A16型(CoxA16)和柯萨奇病毒A6型(CoxA6)核酸;在1111份粪便标本中随机抽取10份进行CoxA6型核酸序列检测及分析。结果2013年长春市儿童医院住院HFMD患儿发病高峰年龄段13-24月龄,流行高峰季节6-8月份 ...
黄艳智   +10 more
doaj  

The Study of Clinical Characteristics in Dry Eye Patients [PDF]

open access: yes, 2015
第一章 干眼患者临床特点的研究 目的:探究干眼患者的临床特点及其影响因素,指导干眼的诊断和治疗。 方法:多中心横断面研究设计,2013年5月至2013年10月期间,联合全国多家眼科门诊搜集3466例干眼患者临床资料。所有患者完成干眼问卷资料及临床干眼相关检查,如BUT、FL、ST-Ⅰ及睑板腺相关检查。 结果:共搜集有效病例3331例,其中男性占34.16%,女性占65.84%。平均年龄为44.7±16.6岁,OSDI评分36.6±16.8,女性患者BUT低于男性(4.4±2.7vs4.5±2.7,P=0.
王燊
core  

Skin barrier, phenotypic and genotypic characterisation of autosomal recessive ichthyosis in TGM1‐deficient Jack Russell Terriers and response to topical ceramide

open access: yesVeterinary Dermatology, Volume 35, Issue 6, Page 617-625, December 2024.
Background – Autosomal recessive ichthyosis leads to structural or biochemical changes that impair skin barrier function. Hypothesis/Objectives – To assess (1) the phenotype and genotype in a litter of Jack Russell Terriers with autosomal recessive congenital ichthyosis (ARCI), and (2) the defective skin barrier and determine if a topical ceramide can ...
Elizabeth Mauldin   +7 more
wiley   +1 more source

The AMP-mimetic AICAR prevents HFD-promoted hepatosteatosis and inhibits liver tumorigenesis [PDF]

open access: yes, 2015
肝细胞癌(Hepatocellularcarcinoma)是最常见的肝脏原位肿瘤。肝癌的 危险因素包括酒精性肝疾病、非酒精性肝炎、肝炎病毒感染等。这些因素都和肝 癌形成中炎症有重要关系。肥胖人群中,肝脏脂质积累造成的非酒精性脂肪肝炎, 肥胖已成为肝癌形成的潜在危险因素。流行病学研究表明,超重和肥胖增加了癌 症发生的风险。在升高体重指数超标的肝癌患者中,由于肝癌死亡的风险是正常 人的4.5倍。文献报道,肥胖通过增加白介素6和肿瘤坏死因子的表达促进肝脏 炎性过程 ...
高建龙
core  

Fetal lower urinary tract obstruction: international Delphi consensus on management and core outcome set

open access: yesUltrasound in Obstetrics &Gynecology, Volume 64, Issue 5, Page 635-650, November 2024.
ABSTRACT Objectives To reach an international expert consensus on the diagnosis, prognosis and management of fetal lower urinary tract obstruction (LUTO) by means of a Delphi procedure, and to use this to define a core outcome set (COS). Methods A three‐round Delphi procedure was conducted among an international panel of experts in fetal LUTO.
H. J. Mustafa   +90 more
wiley   +1 more source

Development of ELISA kit for anti-Epstein-Barr virus antibody and its application in the diagnosis of nasopharyngeal carcinoma [PDF]

open access: yes, 2015
鼻咽癌是中国南部和东南亚地区常见的一种肿瘤,鼻咽癌的发生、发展是EB病毒(Epstein-Barrvirus,EBV)持续感染、遗传因素和环境因素等共同作用的结果。研究表明,提高鼻咽癌的早期诊断率对于提高患者生存率、降低死亡率、改善患者生活质量、降低治疗费用都有重要意义。EBV特异性抗体作为鼻咽癌诊断标志物已有诸多报道并已经应用于临床,但其灵敏度和特异性均有待进一步提高。本研究基于EBV生活史中不同阶段的7种重组EBV抗原建立了相应血清抗体的ELISA检测试剂 ...
许亚蕊
core  

Parliament, petitions and pandemic: Conspiracism in Australia's federal e‐petitions system, 2020−2021

open access: yesPolicy &Internet, Volume 16, Issue 3, Page 485-508, September 2024.
Abstract During the COVID‐19 pandemic, some groups and individuals rearticulated state power through conspiracy theories. Despite their fringe status, conspiracy theory beliefs can directly animate citizen's engagements with institutions. Drawing on Barkun's ‘conventional’ and ‘stigmatised’ knowledge types, we analyse the appearance of conspiracism in ...
Ben Lyall, Patrick Marple
wiley   +1 more source

FBW7α inhibits the proliferation of CCA cells by decreasing the protein expression of c-myc and cyclinE [PDF]

open access: yes, 2016
胆管癌(Cholangiocarcinoma,CCA)是仅次于肝细胞癌的第二大肝脏常见恶性肿瘤,预后差,胆管癌患者的五年生存率仅为5%,而且,近年来其发病率和死亡率呈逐年上升趋势,但是目前对胆管癌发生发展机制的研究还不够深入。 FBW7α(F-boxandWDrepeatdomain-containing7)是一种E3泛素连接酶,可以通过介导底物蛋白的泛素化降解而调控细胞增殖、分化、凋亡、基因组稳定性等细胞进程。FBW7α是一种肿瘤抑制蛋白,在很多肿瘤中发现FBW7的表达减少或者功能缺失,其中 ...
向丹
core  

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