Results 11 to 20 of about 8,323 (166)
Zhejiang Daxue xuebao. Lixue ban, 2003 从江浙蝮蛇毒腺中抽提总RNA,RT-PCR进行体外扩增,获得江浙蝮蛇蛇毒蛋白C激活因子基因,克隆至pGEx-5x-3载体中.对3个重组克隆分别作DNA全序列分析,通过遗传密码推导出相应的氨基酸序列.与其它已知的丝氨酸蛋白酶型蛇毒蛋白的氨基酸作比较,其中许多位置上氨基酸有很强的同源性.该基因的成功克隆,不仅推导出江浙蝮蛇蛇毒蛋白C激活因子的蛋白质序列,也为进一步开展江浙蝮蛇蛇毒蛋白C激活因子蛋白质工程的研究工作打下良好的基础.
WANGYun-gui(王云贵) +4 more
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Zhejiang Daxue xuebao. Lixue ban, 2011 熵值法是一种科学、简单、实用的综合评价方法.由于熵值法是一种客观赋权法，因此可以避免人为因素带来的偏差.以浙江省“十一五”期间6个基础研究学科领域获得浙江省自然科学基金资助项目的情况作为数据源，采用熵值法对这些数据进行分析总结，揭示了浙江省在基础学科领域的研究热点，并据此对浙江省“十二五”期间基础学科领域的研究发展趋势进行了预测和思考.
LIZhi-lan(李志兰)
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PhotoMat, EarlyView., 2023 Photocatalytic water splitting for co‐evolution of H2 and H2O2 is deemed as a sustainable and promising strategy to address energy and environment issues, thus receiving increasing attention and realizing continuous achievements. This review aims to offer a deep understanding of the mechanism for H2 and H2O2 co‐evolution and the design principle of ...
Qiaohong Zhu +4 more
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Trends of drought and flood in Zhejiang Province respond to climatic warming(浙江省汛期旱涝趋势对气候变暖的响应)
Zhejiang Daxue xuebao. Lixue ban, 2007 近50多年来浙江省气候变化总趋势在逐渐变暖，80年代中期开始变暖明显，增幅加大.浙江省汛期各月降水量对气候变暖的响应不同：在季节转换月份5月和9月，降水量明显减小，而在夏季的降水量增加，8月尤甚.在气候变暖期，浙江省汛期旱涝事件的发生频数增加.大气环流对气候变暖的响应是：5月份，高层南亚高压偏弱偏南，中国东南部上空为平直的西风气流，引导冷空气多偏北东移，中层印缅槽的减弱导致向江南水汽输送减少，低层偏南气流远离华东，浙江省主要受单一西北干燥气流影响，降水显著偏少；8月份，青藏高压位置偏西 ...
ZHONGYuan(钟元) +3 more
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PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC
Advanced Science, EarlyView.CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao +16 more
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Advanced Science, EarlyView.Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen +16 more
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Two genera and five species newly recorded in Zhejiang Province, China(浙江植物分布2新记录属和5新记录种)
Zhejiang Daxue xuebao. Lixue ban, 2014 报道了浙江植物分布2新记录属和5新记录种，即野甘草属Scoparia L.，松香草属Silphium L.和山白前Cynanchum fordii Hemsl.,原野菟丝子Cuscuta campestris Yunck.，野甘草Scoparia dulcis L.，串叶松香草Silphium perfoliatum L.,竹节草Commelina diffusa Burm. f..凭证标本均存放于温州大学植物标本室.这些类群在浙江的发现丰富了浙江植物区系的内容，为其在我国地理分布的研究提供了基础资料.
XIONGXianhua(熊先华) +4 more
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Advanced Science, EarlyView.Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong +6 more
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Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism
Advanced Science, EarlyView.The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying +8 more
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