Results 31 to 40 of about 319,333 (182)

Review on Progress of Control of Nitrosamines in Meat Products(肉制品中亚硝胺控制的研究进展) [PDF]

open access: yesShipin kexue jishu xuebao, 2019
Nitrosamines are a type of highly hazardous chemical carcinogens that are easily generated during the processing of meat products. The most common of these are nitrosodimethylamine, diethyl nitrosamine, nitrosopyrrolidine, nitrosopiperidine and ...
YANG Huijuan(杨慧娟)   +7 more
doaj   +1 more source

Amphibious Movement of Microrobots Inspired by Water Spiders

open access: yesAdvanced Science, EarlyView.
Inspired by the water strider, a novel microrobot is designed to maintain amphibious mobility in complex environments. It retains the ability to traverse the air‐liquid interface and perform directional movement within sophisticated, multifaceted environments, including complex gastric wall structures, with precise controllability.
Xiao Hu   +7 more
wiley   +1 more source

Molecular Bases and Genetic Design of Rice Disease Resistance for Optimized Yield and Sustainable Agriculture

open access: yesAdvanced Science, EarlyView.
This study integrates rice immune perception, signal transduction, and resistance output into a multi‐omics framework. By combining high‐throughput sequencing, phenomics, and AI‐assisted design with marker‐assisted selection, gene editing, and rapid domestication, we aim to accelerate the precise breeding of disease‐resistant rice varieties by ...
Xinyue Hou   +4 more
wiley   +1 more source

杜氏盐藻Lhc基因家族的鉴定及镉胁迫下的表达特征

open access: yesHaiyang yu huzhao
镉是广泛存在于水生生态系统的毒害痕量金属,污染水体中痕量金属对水生生物的影响十分重要。光合作用是微藻生长发育的核心过程,Lhc基因家族参与捕光及非光化学淬灭过程,其中包括Lhca和Lhcb亚家族,编码蛋白质构成光合系统捕光复合体。从实验室组装的杜氏盐藻基因组中鉴定了4条Lhca与7条Lhcb基因,通过多序列比对、蛋白质三维结构及保守结构域预测分析其含有保守的Lhc基序。系统发育分析表明,杜氏盐藻与部分微藻及高等植物的Lhc基因聚类相近,且高度保守。q-PCR分析表明,不同镉浓度处理下 ...
吴 铭旭   +3 more
doaj   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

open access: yesAdvanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu   +7 more
wiley   +1 more source

体外培育牛黄通过调控小胶质细胞极化及炎症小体活性干预脑缺血再灌注损伤

open access: yes浙江大学学报. 医学版
目的:探讨体外培育牛黄(ICCB)减轻脑缺血再灌注损伤(CIRI)的机制。方法:分别构建大脑中动脉阻塞(MCAO)大鼠模型和氧糖剥夺/再灌注(OGD/R)BV2细胞模型。其中,大鼠模型于脑缺血1.5 h再灌注72 h后进行改良的神经损伤严重程度评分(mNSS),并测定脑组织含水量和脑梗死体积;苏木精-伊红染色法检测大脑皮层及海马CA1区组织结构病理变化;免疫荧光法检测皮层小胶质细胞极化情况和NOD样受体热蛋白结构域相关蛋白(NLRP)3炎症小体的表达情况。BV2细胞于氧糖剥夺0.5 h再灌注24 h后 ...
褚 坦路   +7 more
doaj   +1 more source

Modulation of the TGF‐β/Smad Signaling Pathway by a Bioactive Oxidized Polygonati Rhizoma Polysaccharide Crosslinked Chitosan Hydrogel as Therapeutic Carrier for Parkinson's Disease Treatment

open access: yesAdvanced Science, EarlyView.
An injectable, self‐healing COPRP hydrogel integrates structurally defined oxidized Polygonati rhizoma polysaccharide with carboxymethyl chitosan through dynamic Schiff‐base crosslinking. The bioactive matrix scavenges reactive oxygen species, suppresses neuroinflammation, protects dopaminergic neurons, and supports sustained levodopa release.
Peng Dai   +10 more
wiley   +1 more source

金庸小說中的「江湖世界」 [PDF]

open access: yes, 2013
武俠小說的世界,有「江湖」、「綠林」、「武林」三種慣稱。「江湖」強調了它的變動性及危險性,「綠林」顯示了它的違法及不合理性,「武林」則限制了他屬於「武人」的屬性。三者各有側重,各有淵源,但唯有等量齊觀,才能真正掌握到武俠小說虛構的「江湖世界」特性。 虛構的「江湖世界」,基本上以真實存在的江湖為藍本,透過闌入、化入的手法,構築出一個自足而完滿的奇異世界,具有濃厚的理想寄託。 金庸小說的江湖世界,以教門、幫派、武學門派為三大支柱。明教、丐幫、少林三大派的凸顯,展示出金庸因襲與開創的「江湖」特色 ...
林保淳
core   +1 more source

Single‐Nucleus Transcriptomic Atlas of Human Vellus Hair Pilosebaceous Units Reveals Age‐Associated Remodeling

open access: yesAdvanced Science, EarlyView.
Human vellus pilosebaceous units (PSUs) remain uncharted. This single‐nucleus atlas reveals coordinated remodeling of the aging PSU niche: reduced bulge stem cell representation with altered regenerative programs, increased representation of a stress‐responsive channel+ epithelial state, enhanced androgen‐responsive sebaceous programs, reduced ...
Ya'nan Li   +9 more
wiley   +1 more source

浙江妈祖信仰的“佛教化”研究 [PDF]

open access: yes, 2015
妈祖的宗教属性问题是妈祖研究的一个重要方面。本文从“佛教化“的角度,以浙江地区为中心,通过大量明清地方志的记载,考察了明清浙江妈祖信仰佛教化的类型和空间分布,分析了妈祖信仰在浙江佛教化的原因 ...
陈政禹
core  

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