Results 11 to 20 of about 8,473 (140)
浙江大学学报. 医学版目的探究拟素化在B细胞介导免疫应答中的调控作用。方法利用Cre-LoxP系统构建B细胞特异性Ube2m基因敲除的CD19cre/+Ube2mfl/fl小鼠，以同窝出生的Ube2mfl/fl小鼠作为正常对照。分别采用非胸腺依赖性抗原4-羟基-3-硝基苯乙酰基（NP）-脂多糖（LPS）、2，4-二硝基苯基（DNP）-Ficoll和胸腺依赖性抗原NP-鸡丙种球蛋白（CGG）、DNP-匙孔血蓝蛋白（KLH）免疫接种小鼠，采用酶联免疫吸附试验检测血清中各类特异性抗体水平，并对NP-LPS和NP ...
金 鑫 +4 more
doaj +2 more sources
茵陈蒿汤主成分治疗代谢相关脂肪性肝病的配伍剂量优化及作用机制实验研究 [PDF]
浙江大学学报. 医学版目的探讨茵陈蒿汤主效应组分栀子苷、绿原酸和大黄多糖改善代谢相关脂肪性肝病（MAFLD）的最佳剂量配比和作用机制。方法将C57BL/6小鼠随机分为正常对照组、模型对照组、均匀设计1~6组、茵陈蒿汤组。除正常对照组外，其余各组采用西方饮食饲料建立MAFLD模型，均匀设计1~6组和茵陈蒿汤组在造模8周后通过灌胃给予相应药物。12周后处死所有小鼠，称取小鼠的体重和肝脏质量，苏木精-伊红染色观察肝组织病理学变化，检测血浆丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）水平，检测血浆及肝脏总胆固醇（TC）、甘油三酯（
高 艳艳 +5 more
doaj +2 more sources
Zhejiang Daxue xuebao. Lixue ban, 2011 熵值法是一种科学、简单、实用的综合评价方法.由于熵值法是一种客观赋权法，因此可以避免人为因素带来的偏差.以浙江省“十一五”期间6个基础研究学科领域获得浙江省自然科学基金资助项目的情况作为数据源，采用熵值法对这些数据进行分析总结，揭示了浙江省在基础学科领域的研究热点，并据此对浙江省“十二五”期间基础学科领域的研究发展趋势进行了预测和思考.
LIZhi-lan(李志兰)
doaj +1 more source
Zhejiang Daxue xuebao. Lixue ban, 2003 从江浙蝮蛇毒腺中抽提总RNA,RT-PCR进行体外扩增,获得江浙蝮蛇蛇毒蛋白C激活因子基因,克隆至pGEx-5x-3载体中.对3个重组克隆分别作DNA全序列分析,通过遗传密码推导出相应的氨基酸序列.与其它已知的丝氨酸蛋白酶型蛇毒蛋白的氨基酸作比较,其中许多位置上氨基酸有很强的同源性.该基因的成功克隆,不仅推导出江浙蝮蛇蛇毒蛋白C激活因子的蛋白质序列,也为进一步开展江浙蝮蛇蛇毒蛋白C激活因子蛋白质工程的研究工作打下良好的基础.
WANGYun-gui(王云贵) +4 more
doaj +1 more source
Advanced Science, EarlyView.An edible biohybrid platform triggers nanoplastics (NPs) aging and agglomeration by in situ generating hydroxyl radicals within the intestine. The enlarged NPs are unable to penetrate the intestine and are subsequently excreted. Simultaneously, probiotic biofilms reinforce the intestinal barrier.
Su Zhou +4 more
wiley +1 more source
Colossal Photovoltaic Current in Ferroelectric Oxide by Constructing Defect Band
Advanced Science, EarlyView.Colossal photovoltaic current density of 34.36 mA/cm2 under 375 nm illumination has been achieved in the Pb‐deficient PbTiO3 film. The ultraviolet photoresponsivity surpasses that of all reported ferroelectric materials. This enhancement is attributed to the junction effect between the Pb‐deficient and non‐defective layers.
Yiran Sun +16 more
wiley +1 more source
Trends of drought and flood in Zhejiang Province respond to climatic warming(浙江省汛期旱涝趋势对气候变暖的响应)
Zhejiang Daxue xuebao. Lixue ban, 2007 近50多年来浙江省气候变化总趋势在逐渐变暖，80年代中期开始变暖明显，增幅加大.浙江省汛期各月降水量对气候变暖的响应不同：在季节转换月份5月和9月，降水量明显减小，而在夏季的降水量增加，8月尤甚.在气候变暖期，浙江省汛期旱涝事件的发生频数增加.大气环流对气候变暖的响应是：5月份，高层南亚高压偏弱偏南，中国东南部上空为平直的西风气流，引导冷空气多偏北东移，中层印缅槽的减弱导致向江南水汽输送减少，低层偏南气流远离华东，浙江省主要受单一西北干燥气流影响，降水显著偏少；8月份，青藏高压位置偏西 ...
ZHONGYuan(钟元) +3 more
doaj +1 more source
A Conserved DT2‐bZIP66‐NF‐YC4 Regulatory Module Confers Drought Tolerance in Rice and Arabidopsis
Advanced Science, EarlyView.This study identifies a conserved tripartiteDT2–bZIP66–NF‐YC4 transcriptional module that enhances rice drought tolerance by activating stress‐responsive genes. This regulatory complex is functionally conserved across cereals and Arabidopsis, providing promising targets for engineering drought‐resilient crops. ABSTRACT Drought stress severely restricts
Jun Shen +18 more
wiley +1 more source
Sliding Ferroelectricity Driven Spin‐Layertronics in Altermagnetic Multilayers
Advanced Science, EarlyView.Integrating sliding ferroelectricity with altermagnetism enables nonvolatile electrical control of spin and layer degrees of freedom. In bilayer CuF2, interlayer translation reverses layer‐locked spin‐split bands, establishing a multifunctional “spin‐layertronic” platform.
Rui Peng +5 more
wiley +1 more source