Results 31 to 40 of about 47,871 (257)
Advanced Science, EarlyView.A macrophage–platelet conjugation system (M‐P‐NPs@PPARγ) targets injure tissue to co‐deliver platelet mitochondria and PPARγ‐encoding NPs. This strategy boosts the macrophage energy supply and restores lipid homeostasis, leading to synergistically enhanced efferocytosis and tissue repair Abstract Mitochondrial dysfunction occurs in macrophages with ...
Haoli Wang +18 more
wiley +1 more source
活动范围对青鳉鱼
Haiyang yu huzhao重尾分布现象广泛存在于自然界的各种生物运动模式之中，重尾分布现象会随环境的变化而变化。鱼类为适应生存环境，往往会选择更加高效的个体运动模式。以青鳉鱼(Oryzias latipes)为研究对象，在相同浅水条件(5 cm)下，控制其活动范围，探究青鳉鱼在不同水域面积(1.0 m×1.0 m、0.6 m×0.6 m、0.4 m×0.4 m、0.2 m×0.2 m以及0.1 m×0.1 m)条件下的运动模式。利用MATLAB软件将青鳉鱼的运动轨迹转换为具体数据，通过移动速度、移动加速度 ...
龚 晓斌 +5 more
doaj +1 more source
Study on Administrative System Reform in Zhejiang Zhoushan Islands New Area [PDF]
, 2016 国家级新区是近年来通过深层次制度改革引领区域发展的一种新的国家改革战略，它承担着在各个领域先行先试的任务，力图为区域发展起到增长极作用，也为全国范围内的重要改革发展和体制机制创新起到先导和示范作用。浙江舟山群岛新区是国务院批复的第四个国家级新区，也是我国首个以海洋经济为主题特色的国家级新区。在新区获批后，舟山群岛新区于2013年启动了以“三强三优”为主要内容的行政体制改革。以浙江舟山群岛新区为案例研究对象，探讨其行政体制改革的现实基础、改革内容和深化路径，有利于为治理现代化的体制机制建设提供实践范本 ...
王一珵
core
Advanced Science, EarlyView.This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong +15 more
wiley +1 more source
Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism
Advanced Science, EarlyView.The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying +8 more
wiley +1 more source
Design and Implementation of Wenzhou Environmental Monitoring System Based on GIS [PDF]
, 2016 随着经济社会发展水平的提高，广大人民群众对物质文化生活水平的需求日趋提升，在物质生活越来越丰富的今天，群众对环境、生态等生存环境给予了更多的关心和关注，都渴望清新的空气、安全的饮用水、优良的生态环境和更多的青山绿水。温州市环境保护局监测中心主要负责全市范围内重点区域和重点污染因子的管理监测工作，主要提供对环境保护数据的自动采集、自动传输、处理分析和快速反应于一体的服务工作，负责对空气、水、污染源等监测系统建设和运 用。 本文主要介绍了温州市环境监测系统的研发过程，结合软件工程的理论知识 ...
薛成慧
core
S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning
Advanced Science, EarlyView.Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu +6 more
wiley +1 more source
Zhejiang Daxue xuebao. Lixue ban报道了我国薹草属的若干省级分布新记录种，安徽新记录种互花薹草Carex alterniflora，贵州新记录种翠丽薹草C. speciosa和纤细薹草C. pergracilis，浙江新记录种武夷山薹草C. wuyishanensis和闽北薹草C. borealifujianica，湖南新记录种武夷山薹草C. wuyishanensis、等高薹草C. aequialta和金佛山薹草C.
鲁益飞(LU Yifei) +4 more
doaj +1 more source
Haiyang yu huzhao镉是广泛存在于水生生态系统的毒害痕量金属，污染水体中痕量金属对水生生物的影响十分重要。光合作用是微藻生长发育的核心过程，Lhc基因家族参与捕光及非光化学淬灭过程，其中包括Lhca和Lhcb亚家族，编码蛋白质构成光合系统捕光复合体。从实验室组装的杜氏盐藻基因组中鉴定了4条Lhca与7条Lhcb基因，通过多序列比对、蛋白质三维结构及保守结构域预测分析其含有保守的Lhc基序。系统发育分析表明，杜氏盐藻与部分微藻及高等植物的Lhc基因聚类相近，且高度保守。q-PCR分析表明，不同镉浓度处理下 ...
吴 铭旭 +3 more
doaj +1 more source
Mathematical Prediction for Geometry‐Mediated Cell 3D In‐Growth on Bone Tissue Engineering Scaffolds
Advanced Science, EarlyView.This study identifies a fundamental pore size dependent pattern of three dimensional bone marrow derived mesenchymal stem cell (BMSC) infiltration within porous scaffolds, where small pores promote horizontal cellular bridging and large pores facilitate vertical migration.
Xiang Gao +15 more
wiley +1 more source