淀粉样前体蛋白胞内结构域对阿尔茨海默病模型小鼠神经发生和学习记忆的影响
Zhongshan Daxue xuebao. Yixue kexue ban目的探讨淀粉样前体蛋白胞内结构域（AICD）对阿尔茨海默病（AD）模型动物神经发生、学习记忆的影响。方法本研究使用免疫荧光染色检测AICD转基因小鼠来源的体外培养的神经前体细胞（NPCs）、胚胎大脑皮质、成年海马齿状回（DG）中增殖和分化的细胞数目；水迷宫实验检测老年AICD转基因小鼠对学习记忆能力影响；生物信息学预测和分析潜在的分子机制。结果免疫荧光染色结果显示AICD转基因模型体外NPCs、胚胎皮质、海马DG区域的神经干细胞和神经元数量减少（P < 0.05 ...
蒋梅 +4 more
doaj
大麻素1型受体在实验性自身免疫性脑脊髓炎小鼠中的 动态表达及其作用
Zhongshan Daxue xuebao. Yixue kexue ban, 2014 摘 要: 【目的】 观察大麻素1型受体(CB1R)在C57B/L6小鼠神经元和胶质细胞的表达及其在实验性自身免疫性脑脊髓炎(EAE)小鼠中枢神经系统(CNS)和外周免疫器官的动态变化及其作用?【方法】 取C57B/L6胎鼠的海马培养神经元及新生C57B/L6新生小鼠的皮层培养星形胶质细胞和小胶质细胞, 观察CB1R蛋白的表达;观察正常对照?完全弗氏佐剂?EAE 和特异性CB1R抑制剂(SR141716A,SR1)干预组小鼠的神经功能缺损症状和体质量变化;用real time PCR检测CB1R ...
doaj
颈交感神经干离断可通过抑制内质网应激降低大鼠脑缺血再灌注损伤
Zhongguo shiyan zhenduanxue目的观察星状神经节阻滞（SGB）对大鼠脑缺血再灌注（I/R）损伤的影响及内质网应激（ERS）在其中发挥的作用。方法采用右侧颈交感神经干离断术（TCST）模拟星状神经节阻滞，将雄性SD大鼠分为5组：①假手术组（Sham）；②脑缺血再灌注组（I/R）；③TCST预处理+I/R组（I/R+TCST）④TCST预处理+ERS激动剂衣霉素（TM）+I/R组（I/R+TCST+TM）；⑤ERS抑制剂4-苯基丁酸（4PBA）预处理+I/R组（I/R+4PBA）。术后24 h评估以下指标：①神经功能缺损评分 ...
张云飞, 辛楠, 田海涛
doaj
[Electroacupuncture at Baihui and Zusanli improves fear memory extinction in single prolonged stress mice by activating hippocampal astrocytes]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoChen X +7 more
europepmc +1 more source
[Modified <i>Gandou</i> Decoction improves cognitive function of TX mice with Wilson's disease by inhibiting the PKR/eIF2α pathway]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoXu C, Han Y, Cheng N, Dong J.
europepmc +1 more source
[<i>Lactobacillus plantarum</i> alleviates lead exposure-induced learning and memory impairment in mice by regulating bile acid metabolism and inhibiting hippocampal NLRP3 expression]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoLi L, Yu W, Tan M, Li Y, Liu A, Meng X.
europepmc +1 more source
[Electroacupuncture improves post-traumatic stress disorder in rats by alleviating hippocampal mitochondrial injury <i>via</i> regulating Bcl-2/Bax/caspase-3 signaling]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoMa D, Cheng J, Zhang H, Liu G, Song K.
europepmc +1 more source
[Research progress on maternal factors influencing the risk of autism spectrum disorder in offspring from a gut-brain axis perspective]. [PDF]
Zhongguo Dang Dai Er Ke Za ZhiDing HB, Li C, Wu SL.
europepmc +1 more source
[<i>Zhizichi</i> Decoction alleviates depression-like behaviors in rats exposed to chronic unpredictable mild stress by modulating tryptophan metabolism and the BDNF signaling pathway]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoMeng T, Qin M, Xia Y.
europepmc +1 more source
[Oral homeostasis imbalance under hypoxia]. [PDF]
Hua Xi Kou Qiang Yi Xue Za ZhiXu Y, Wang S, Zhou J.
europepmc +1 more source