[Photobiomodulation Promotes Hippocampal Neurogenesis and Improves Cognitive Function and Anti-Inflammatory Injury in Rats With Chronic Cerebral Hypoperfusion]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue Ban, 2023 目的 探讨光生物调节（photobiomodulation, PBM）对脑慢性低灌注大鼠海马神经元再生及认知功能和炎症损伤的影响。 方法 将雌性SD大鼠去双侧卵巢，1周后随机分为假手术组（Sham）、BCCAO组、PBM干预组（BCCAO+PBM），每组8只。BCCAO组永久性结扎大鼠双侧颈总动脉（bilateral common carotid artery occlusion, BCCAO）建立脑慢性低灌注模型，但不予光照；Sham组只钝性分离左、右侧颈总动脉，但不结扎，不予光照。BCCAO ...
Tu J, Huang Y, Huang Y, Wu M, Wang R.
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Latest Research on the Neuroprotective Mechanism of Short-chain Fatty Acids in Stroke and Its Relation with Post-stroke Cognitive Impairment [PDF]
, 2022 Post-stroke cognitive impairment is one of the common complications of stroke, seriously affecting patients' ability to perform activities of daily living.
LIU Huanhuan, LI Ruiqing, SU Kaiqi, YUAN Jie, LI Qi, FENG Xiaodong
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Developments in the Role of Iron Imbalance in the Pathogenesis of Alzheimer's Disease [PDF]
, 2022 Iron load is closely associated with the initiation and progression of Alzheimer's disease (AD) . Although age-dependent deposition of β-amyloid (A β) in senile plaques (SPs) , and neurofibrillary tangles (NFTs) formed by accumulation ...
GUO Shuang, CHEN Fengyan, YIN Xiang, WANG Lu, GUO Xuefeng, YU Qiming, ZOU Zhenyou, SHU Wei
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, 2021 运动训练是脑卒中后康复治疗的主要手段。运动训练可以促进脑卒中后神经功能的恢复，其作用目前普遍认为与神经可塑性有关，但具体机制未明。运动训练的神经可塑性机制是当前脑卒中康复研究领域的热点问题。运动训练可以调节脑卒中后脑内血流动力学变化、血管新生、神经炎症反应、营养因子分泌、神经细胞死亡及新生等。本文基于国内外研究，探讨脑卒中后最适的运动干预方案，并结合我们团队在运动训练促进脑卒中后神经功能恢复方向所做的系列研究工作 ...
胡昔权
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Advances in Neuropathologic Research of Hypoglycemic Brain Damage Caused by Insulin Overdose [PDF]
, 2020 The number of death from insulin overdose, including accidental poisoning, suicide and homicide, is increasing these years. The forensic diagnosis of death from insulin overdose is a tough task. Glucose is the main energy source of the brain.
TONG Fang, YANG Yi, LIANG Yue, et al.
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电针对SNI诱导疼痛抑郁模型大鼠海马AcH3/BDNF的影响 [PDF]
, 2023 目的观察电针对疼痛抑郁模型大鼠海马脑源性神经营养因子（BDNF）、乙酰化蛋白（AcH3）表达的影响，探讨电针镇痛抗抑郁的作用机制。方法雄性SD大鼠随机分为假手术组、模型组、电针组、药物组，每组6只。采用坐骨神经选择损伤术（SNI）建立疼痛抑郁模型。SNI术后1周进行相关干预直至术后6 周，电针组于隔日电针百会、印堂2 Hz 30 min治疗；药物组给予每日10 mg/kg丙咪嗪腹腔注射；假手术组、模型组给予相同的抓取。术前及术后1、2、3、4、5、6 周进行机械缩足反射阈值（PWT）测试 ...
刘健华 +6 more
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Advances in the Study of Natural Product Polysaccharides for the Relief of Depression and Their Mechanisms [PDF]
, 2023 Depression, as a common mental disorder, is often alleviated and treated with antipsychotic drugs in clinical practice. However, long-term use of such drugs can lead to serious sequelae such as drowsiness, nausea and memory loss in patients.
Yuhe BAI
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The Role and Mechanism of MicroRNA-219 in Epileptogenesis [PDF]
, 2015 目的：通过海人酸、匹罗卡品诱导C57BL/6、ICR小鼠癫痫持续状态发作，制造人类颞叶癫痫动物模型，探讨microRNA-219在癫痫发病中的功能通路及调控网络的动态变化，为癫痫的诊断提供新的依据，为抗痫药物研制提示新的作用靶点。 方法：用成年雄性C57BL/6、ICR小鼠为研究对象，侧脑室注射海人酸（Kainicacid，KA）或腹腔注射匹罗卡品诱发小鼠癫痫发作，建立小鼠癫痫动物模型。24小时后检测小鼠皮质脑电图改变并运用荧光定量PCR方法检测小鼠海马和皮质中microRNA-219表达变化情况 ...
唐荣
core
oleoylethanolamide improves spatial cognitive deficits through enhancing hippocampal neurogenesis after cerebral ischemia [PDF]
, 2015 我们先前的研究表明油酰乙醇胺（OEA）对急性脑缺血损伤具有神经保护作用。本研究的目的是探讨OEA对脑缺血引起的空间认知障碍，海马长时程增强作用（LTP）的抑制作用和海马神经发生的影响。结果表明：OEA30mg/kg显著改善大鼠脑缺血后空间认知功能障碍，促进海马长时程增强。另外，我们证实OEA通过促进海马神经发生改善脑缺血后的认知障碍。进一步的研究表明，OEA明显增加海马组织脑源性神经营养因子（BDNF）和过氧化物酶体增殖活化受体（PPARα）的表达 ...
杨立朝
core
Study on the Function of the Neuron-Specific Protein TMEM59L in the Central Nervous System and in Oxidative Stress-Induced Cell Death [PDF]
, 2016 细胞凋亡是受基因严格调控的、自然发生的程序性细胞死亡过程，而细胞自噬是细胞组分自我降解的过程，二者在发育、组织稳态以及病原体防御中扮演着重要角色。细胞凋亡和细胞自噬发生异常会引发多种疾病包括癌症和神经系统疾病。神经元对于氧化应激十分敏感，并易于受到活性氧的攻击；当神经元长期暴露于包括过氧化氢在内的活性氧的攻击时会引发细胞死亡，导致各种神经系统疾病。因此，鉴定参与神经元死亡的新基因蛋白并揭示其作用机制，将有助于阐明神经系统疾病的致病机理。 TMEM59L为新发现的脑特异性高表达蛋白 ...
郑秋阳
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