Results 31 to 40 of about 5,903 (148)

Expression and Clinical Significance of mTOR and PTEN in Non-small Cell Lung Cancer [PDF]

open access: yes, 2010
Background and objective It has been proved that mTOR was an important signal transduction molecular and protein kinase regulating cell growth and proliferation, and mTOR could activate the downstream protein effector. PTEN could negatively regulate mTOR
Liang WANG   +5 more
core  

Risk Factors and Prognosis of Patients with Para-Aortic Lymph Node Metastasis of Advanced Esophagogastric Junction Malignancy [PDF]

open access: yes
ObjectiveTo determine the risk factors and prognostic survival of patients with para-aortic lymph node metastasis of advanced esophagogastric junction malignancy by comparing their general clinicopathological characteristics and regional lymph node ...
Quan NIU, Xiaogang BI
core   +1 more source

基于ACR TI-RADS分类对甲状腺乳头状癌淋巴结转移风险模型的预测

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2018
【目的】应用美国放射学会(ACR)甲状腺影像报告及数据系统(ACRTI-RADS2017)对甲状腺乳头 状癌患者转移风险进行评估,提高超声对甲状腺转移癌检出率。【方法】回顾分析经病理确诊的甲状腺乳头状癌 163例,根据术后N分期分为转移与非转移2组,对照临床和病理特征,对ACRTI-RADS评分与甲状腺乳头状癌 患者发生淋巴结转移的关系进行单因素和多因素分析。【结果】发生淋巴结转移患者TI-RADS评分为12.0 (10.0,14.0),高于未发生转移的患者(P=0.003 ...
何学森   +3 more
doaj  

Influencing factors of recurrence after surgery among Chinese female breast cancer patients:a meta-analysis [PDF]

open access: yes, 2017
目的探讨中国女性乳腺癌患者术后复发的影响因素,为改善乳腺癌患者预后提供参考依据。方法检索中国学术文献总库(CNKI); 、万方数据库、中国生物医学文献数据库(CBM) 、Web Of Science数据库、Pubmed数据库、Science; Direct数据库和BIOSIS数据库,并辅以手工检索和文献追溯法收集2000年1月1日-2013年12月31日公开发表的关于中国女性乳腺癌患者; 术后复发影响因素的相关文献;应用RevMan 5.2和SAS; 9.2软件对纳入的文献进行meta分析 ...
刘玲玲, 方亚, 林芳, 韩耀风
core  

早期巨块型宫颈癌淋巴结转移的规律及其与预后的关系

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2016
【目的】 探讨早期巨块型宫颈癌患者淋巴结转移分布的规律及其与预后的关系。【方法】 回顾性分析2011年1月至2015年3月在汕头大学医学院附属肿瘤医院收治的157例局部晚期宫颈癌患者(局部肿瘤>4 cm的Ib2或Ⅱa2期),收集其临床病理资料,并随访患者生存情况。【结果】157例患者中50例(31.8%)发生淋巴结转移(LNM),以闭孔/宫旁淋巴结转移最常见;10例(6.4%)发生髂总淋巴结转移;腹主动脉旁淋巴结阳性的患者均伴有盆腔淋巴结转移。病理类型、深肌层浸润、淋巴脉管间隙浸润 ...
doaj  

RT-PCR检测胃癌无转移淋巴结(PN0)微转移的临床意义

open access: yesZhongguo shiyan zhenduanxue, 2003
目的 从分子水平对胃癌淋巴结微转移进行诊断分级 ,评价胃癌临床分期及预后。方法 应用RT PCR方法 ,以细胞角蛋白 18(CK18)为标志基因 ,检测对照组良性病变淋巴结 2 0枚 ,胃癌组无转移淋巴结 (PN0 ) 199枚。结果 ①对照组良性病变淋巴结中无CK18mRNA表达 ,与病理符合率 10 0 %。胃癌组病理检查为阴性的 199枚淋巴结中有CK18mRNA阳性表达 34枚 ,阳性率 17.1%。②胃癌淋巴结微转移 (LMM)与肿瘤临床病理参数浸润 (T)呈正相关。结论 用RT ...
续薇   +5 more
doaj  

DNA Methylation and Non-small Cell Lung Cancer [PDF]

open access: yes, 2010
Genomic DNA methylation is a major form of epigenetic modification. Hypermethylation could affect the binding of transcription factors to DNA and change the structure of chromatin resulting in silence of tumor suppressor genes, which plays an important ...
Longbang CHEN, Youwei ZHANG
core  

A study on the correlation between plasmacytoid dendritic cells and lymph node metastasis in advanced gastric cancer [PDF]

open access: yes
Background and purpose: Plasmacytoid dendritic cells are one of the key immune cells in the tumor microenvironment (TME), which can directly or indirectly regulate tumor related immune responses and play multiple roles in the development and metastasis ...
CHEN Zhanwei, WU Yaoqiang, WANG Yanping, ZHANG Dejian, YU Fuxiang
core   +1 more source

Clinical significance of RRM1, CDX2 expression in different gastric mucosa lesions [PDF]

open access: yes, 2017
目的探讨核苷酸还原酶亚单位M1(ribonucleotide reductase M1,RRM1)、尾型同源盒转录因子2(caudal-related homeobox transcription factor 2,CDX2)在不同胃黏膜组织中的表达,并分析其与胃癌发生发展及预后的关系。方法选取中国人民解放军第一七五医院病理科保存的组织蜡快240例,其中胃癌90例、高级别上皮内瘤变30例、低级别上皮内瘤变30例、肠上皮化生30例、浅表性胃炎30例、正常胃黏膜30例,采用S ...
刘美莲   +5 more
core   +1 more source

乳腺癌淋巴转移与Galectin-3、CA19-9表达的相关性研究

open access: yesZhongguo shiyan zhenduanxue, 2017
目的通过检测乳腺癌组织中半乳凝素-3(Galectin-3)、CA19-9的表达,探讨Galectin-3、CA19-9与乳腺癌淋巴结转移的相关性研究。方法对85例乳腺癌患者手术切除的癌组织:(1)进行常规连续切片HE染色病理诊断、分期。(2)应用免疫组织化学方法检测癌组织中及癌旁组织Galectin-3、CA19-9的表达水平;(3)结合淋巴结转移情况进行分析对比。结果 (1)有淋巴结转移组的癌组织Galectin-3和CA19-9表达与无淋巴结转移组癌组织中的表达有差异性改变 ...
颜文贞, 戴璟, 田猛, 戴东
doaj  

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