A study on the correlation between plasmacytoid dendritic cells and lymph node metastasis in advanced gastric cancer [PDF]
Background and purpose: Plasmacytoid dendritic cells are one of the key immune cells in the tumor microenvironment (TME), which can directly or indirectly regulate tumor related immune responses and play multiple roles in the development and metastasis ...
CHEN Zhanwei, WU Yaoqiang, WANG Yanping, ZHANG Dejian, YU Fuxiang
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Study on the effects of down-regulating Annexin A3 expression on biological behaviors of lung adenocarcinoma and its molecular mechanism [PDF]
, 2015 肺癌是我国第一大癌症，其发病率和死亡率均居恶性肿瘤之首，严重危害人类健康。肺癌按组织学类型可分为鳞癌、腺癌、小细胞癌和大细胞癌。近年来，肺腺癌（lungadenocarcinoma，AdC）的发病率呈逐步上升趋势，且患者死亡率高、预后极差。癌细胞易转移是肺腺癌患者预后差的主要原因，因此，探寻肺腺癌转移的分子机制及其新的治疗靶标，对于提高肺腺癌患者预后意义重大。我们前期研究中，采用定量蛋白质组学技术鉴定出AnnexinA3（Anxa3）为一个新的肺腺癌转移相关分子 ...
刘青青
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Invasion and Metastasis Significance of Serum MMP-9 in Lung Cancer Patients [PDF]
目的 研究基质金属蛋白酶-9(matrix metalloproteinase 9，MMP-9)在肺癌患者侵袭和转移的意义。方法 收集肺癌患者血清70例，健康体检者血清60例，通过酶联免疫吸附法(ELISA)检测鳞癌、腺癌、小细胞肺癌患者和不同年龄健康者血清样本中MMP-9的表达水平，进行统计学分析。结果 MMP-9在肺癌患者血清中的含量明显高于健康人群；且伴有淋巴结转移组血清MMP-9水平显著高于无淋巴结转移组；在鳞癌组、腺癌、小细胞肺癌组组间差异无统计学意义；在不同年龄的健康组中差异无统计学意义 ...
HOU, Pan-fei +3 more
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能谱CT定量指标在鉴别诊断非小细胞肺癌转移淋巴结与非转移淋巴结中的价值
Zhongshan Daxue xuebao. Yixue kexue ban, 2014 摘 要: 【目的】 评估能谱CT定量指标鉴别诊断非小细胞肺癌(NSCLC)转移淋巴结与非转移淋巴结的价值?【方法】 对48例非小细胞肺癌转移淋巴结(n = 34)与非转移淋巴结(n = 40)的CT平扫?动脉期及静脉期能谱定量指标进行比较? 【结果】 转移淋巴结平扫及动脉期碘基物质密度?平扫及动脉期有效原子序数?平扫及动脉期标化有效原子序数?动脉期标化碘基物质密度均低于非转移淋巴结组,差异均具有统计学意义(P 0.1574,诊断淋巴结为良性的正确几率分别为86.7%?【结论 ...
doaj
DCE-MRI定量灌注参数鉴别直肠癌区域淋巴结良恶性的初步探讨
Zhongshan Daxue xuebao. Yixue kexue ban, 2017 【目的】采用DCE-MRI定量灌注参数评价直肠癌区域淋巴结，以探究各参数鉴别良恶性淋巴结的临床应用价 值。【方法】收集本院2015年1月至2016年8月行术前DCE-MRI扫描且未经新辅助治疗行直肠癌根治术患者122例，纳入 术前DCE-MRI与术后病理相对应淋巴结203枚（阳性95枚，阴性108枚），测量各淋巴结短径（S）、长径（L）并计算二者比值 （S/L），测算各淋巴结定量灌注参数，包括对比剂容积转换常数（K trans ）、速率常数（K ep ）、单位体积组织细胞外血管外间隙容量 （V ...
杨心悦 +5 more
doaj
The role of TNFAIP8 family in gastric cancer and heart transplantation [PDF]
, 2016 摘要 目的：TIPE及TIPE2是TNFAIP8（Tumornecrosisfactor-αinducedprotein-8，TIPE，TNFAIP8）家族的重要成员，TIPE是调控凋亡进程的重要分子，本研究之一是应用TIPE不同表达的BGC823细胞株建立胃癌裸鼠移植瘤模型，观察TIPE对移植瘤生长的影响；同时收集并检测胃癌临床标本TIPE的表达特点，分析TIPE与胃癌临床病理特征的关系，明确TIPE与胃癌生物学行为的关系及对胃癌生长的影响。 TIPE2为免疫负性调控因子，对免疫稳态的维持起重要作用 ...
洪诗福
core
Development of ELISA kit for anti-Epstein-Barr virus antibody and its application in the diagnosis of nasopharyngeal carcinoma [PDF]
, 2015 鼻咽癌是中国南部和东南亚地区常见的一种肿瘤，鼻咽癌的发生、发展是EB病毒（Epstein-Barrvirus，EBV）持续感染、遗传因素和环境因素等共同作用的结果。研究表明，提高鼻咽癌的早期诊断率对于提高患者生存率、降低死亡率、改善患者生活质量、降低治疗费用都有重要意义。EBV特异性抗体作为鼻咽癌诊断标志物已有诸多报道并已经应用于临床，但其灵敏度和特异性均有待进一步提高。本研究基于EBV生活史中不同阶段的7种重组EBV抗原建立了相应血清抗体的ELISA检测试剂 ...
许亚蕊
core
Long-term Survival of Personalized Surgical Treatment of Locally Advanced Non-small Cell Lung Cancer Based on Molecular Staging [PDF]
, 2011 Background and objective Approximately 35%-40% of patients with newly diagnosed non-small cell Lung cancer have locally advanced disease. The average survival time of these patients only have 6-8 months with chemotherapy.
Bin LIU +16 more
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Correlation of multiple inflammatory indices in peripheral blood with postoperative recurrence and metastasis in oral squamous cell carcinoma patients [PDF]
Objective To investigate the associations of multiple immunoinflammatory markers in peripheral blood before and after operation, such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR ...
GUHAIERNISHA·Kaihereman, WULAN·Jinensi, YAO Zhitao
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Esophageal cancer complicated with extensive cervical lymph node metastasis： a case report [PDF]
Cervical tumors may occur in a variety of benign and malignant tumors. It is difficult to make a correct diagnosis in the absence of other systemic symptoms and pathological biopsy， which is likely to delay the optimal treatment opportunity.
Wang Qianqian, Zou Kongzhen, Zhang Xiaoyu, Lin Pingping
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