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JGH Open, Volume 7, Issue 12, Page 936-941, December 2023., 2023 The aim of this study was to assess the quality and content of short videos Douyin and TikTok for educational role on early screening of rectal cancer. We found that in terms of quality score and content score, the Chinese videos on Douyin exhibit superiority over the English and Japanese videos on TikTok.
Lian‐Shuo Li +10 more
wiley +1 more source
Systematic review of shared decision‐making in guidelines about colorectal cancer screening
European Journal of Cancer Care, Volume 31, Issue 6, November 2022., 2022 Abstract Introduction We aimed to systematically evaluate quality of shared decision‐making (SDM) in colorectal cancer (CRC) screening clinical practice guidelines (CPGs) and consensus statements (CSs). Methods Search for CRC screening guidances was from 2010 to November 2021 in EMBASE, Web of Science, MEDLINE, Scopus and CDSR, and the World Wide Web ...
Marta Maes‐Carballo +6 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2022 目的 探究釉丛蛋白1(TUFT1)在直肠癌组织中的表达水平及其对直肠癌的诊断和预后价值。方法 利用Ualcan数据库分析TUFT1 mRNA在正常直肠组织及直肠癌组织中的表达水平；选取2014年12月～2018年4月新乡市第一人民医院诊治的77例直肠癌患者为研究对象，实时荧光定量PCR(qRT-PCR)法测定直肠癌组织、癌旁正常组织TUFT1 mRNA表达水平；分析直肠癌组织TUFT1 mRNA表达水平与直肠癌患者临床病理特征的关系；受试者工作特征曲线(ROC曲线)评价直肠组织TUFT1 ...
王坤, 张玉盼, 杨亚鹏
doaj
The Oncologist, Volume 24, Issue 11, Page 1416-1419, November 2019., 2019 Abstract Immune checkpoint blockade (ICB) is an approved therapy for advanced metastatic mismatch repair (MMR)‐deficient cancer regardless of tissue of origin. Although therapy is effective initially, recurrence rates are significant, and long‐term outcomes remain poor for most patients.
Arthur Winer +7 more
wiley +1 more source
The Oncologist, Volume 23, Issue 1, Page 7-15, January 2018., 2018 Abstract Background This study compared the efficacy of regorafenib and trifluridine/tipiracil (TFTD) in patients with metastatic colorectal cancer (mCRC) who are refractory to standard chemotherapy, because despite their clinical approval, it still remains unclear which of these two drugs should be used as initial treatment.
Toshikazu Moriwaki +25 more
wiley +1 more source
Impact of commonly prescribed drugs on the risk of colorectal cancer [PDF]
, 2023 Colorectal cancer (CRC) stands as the fourth most prevalent cancer worldwide and the third most common in Sweden. Characterized by a protracted progression stage and insidious onset, CRC poses a considerable challenge for early detection.
Liu, Qing
core +1 more source
Zhongguo shiyan zhenduanxue, 2023 结直肠癌作为癌症相关死亡的第四大原因，也是全球第三大最常诊断的恶性肿瘤。在东欧和亚洲地区，结直肠癌的发病率和死亡率上升迅速，预计到2030年，全球结直肠癌患者将新增220万确诊病例以及110万的死亡病例[1]。在最近的研究报告中指出进行结直肠癌早期癌症筛查诊断能显著降低结直肠癌死亡率[2],本实验初步通过二维色谱质谱联用技术及免疫印迹实验来分析RPS14蛋白在结直肠癌组织与癌旁组织的差异，为结直肠癌的筛查和诊断提供帮助。
岳斯琦, 魏丽萍, 何成彦
doaj
Study of regulation of OVOL2 in colorectal cancer metastasis and invasion [PDF]
, 2016 OVOL2是进化上相当保守的一种转录因子，它与胚胎发育之间的关系已经被很多研究所报道，但是OVOL2与肿瘤的发生发展关系还知之甚少。本文主要从OVOL2是如何调控结直肠癌的转移与侵袭方面做了详细的研究。 首先我们从结直肠癌病人样本的组织芯片中发现肿瘤中OVOL2含量低的病人预后生存期更短。然后我们通过体外细胞增殖实验、裸鼠皮下成瘤实验、小鼠免疫组化实验、HE染色实验证实了OVOL2不能够抑制结直肠癌的增殖。于是我们猜测OVOL2可能是通过抑制结直肠癌转移和侵袭过程，延长患者的寿命 ...
孙广斌
core
Studies of Functions and Mechanisms of JMJD2D in the Development of Colorectal Cancer [PDF]
, 2015 结直肠癌（Colorectalcancer,CRC）是世界范围内的高发性恶性疾病，其发病率和死亡率呈逐年上升趋势，因而引起广大科研工作者对其发生发展的作用机制进行深入研究。文献报导称，在绝大多数结直肠癌的发生发展过程中都伴随着经典Wnt信号通路的异常激活。该通路激活后，其中最重要的效应分子之一β-Catenin入核与TCF/LEF家族成员结合，激活下游促癌基因转录表达，从而促进结直肠癌的发生发展。 组蛋白赖氨酸特异性去甲基化酶4D（Lysine-specificdemethylase4D,KDM4D ...
余力
core
The Effects and Mechanisms of JMJD1A on Colorectal Tumorigenesis [PDF]
, 2015 结直肠癌（colorectalcancer，CRC）是当今世界高发恶性肿瘤之一，多数由散发腺瘤阶段性发展而来，少数结肠癌的发生呈家族性聚集现象或由炎性肠病诱导发生。对结肠癌的早期筛查与诊断是结肠癌防治重点，由于结肠癌患者个体间差异性大，对靶向药物的开发是未来结肠癌治疗的重要辅助手段。 组蛋白去甲基化酶JMJD1A(Jumonjidomaincontaining1A)通过羟基化作用使组蛋白赖氨酸去甲基进而行使转录调节功能，参与精子生成、能量代谢、干细胞更新调控，也参与低氧诱导下的肿瘤调控 ...
苗萌萌
core