Results 21 to 30 of about 355,337 (149)
The Oncologist, Volume 24, Issue 11, Page 1416-1419, November 2019., 2019 Abstract Immune checkpoint blockade (ICB) is an approved therapy for advanced metastatic mismatch repair (MMR)‐deficient cancer regardless of tissue of origin. Although therapy is effective initially, recurrence rates are significant, and long‐term outcomes remain poor for most patients.
Arthur Winer +7 more
wiley +1 more source
The Oncologist, Volume 23, Issue 1, Page 7-15, January 2018., 2018 Abstract Background This study compared the efficacy of regorafenib and trifluridine/tipiracil (TFTD) in patients with metastatic colorectal cancer (mCRC) who are refractory to standard chemotherapy, because despite their clinical approval, it still remains unclear which of these two drugs should be used as initial treatment.
Toshikazu Moriwaki +25 more
wiley +1 more source
, 2021 Currently, surgery, usually supplemented with other adjunctive therapies, is the only potentially curative treatment modality for rectal cancer. There are tree common types of radical resection of rectal carcinoma: abdominoperineal resection (Miles ...
WANG Yan (王燕) +5 more
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, 2023 This paper summarized the common complications and influencing factors after preventive ileostomy closure for lower rectal cancer. Related nursing strategies were analyzed to provide reference for reducing complication rates and relieve clinical symptoms
MA Peifang (马培芳) +1 more
core +1 more source
, 2022 目的既往有多个报道结直肠癌转移方式的研究，但尚缺少基于长期随访并以死亡作为观察终点，总结CRC转移部位、发生率以及相关生存数据的研究。方法本研究回顾中山大学附属第六医院373例结直肠癌死亡患者资料，统计分析肿瘤转移的部位、发生率以及生存资料。结果334例（89.5%）患者为肿瘤相关性死亡，肝转移率为51.5%，肺转移率为40.4%，腹膜转移率为55.7%。单纯肝、肺、腹膜转移患者数分别为27例（8%）、21例（6.3%）、63例（18.9%）。单纯肺转移患者生存明显优于单纯肝转移或单纯腹膜转移（P<
陈晓琼 +7 more
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Zhongguo shiyan zhenduanxue, 2023 结直肠癌作为癌症相关死亡的第四大原因，也是全球第三大最常诊断的恶性肿瘤。在东欧和亚洲地区，结直肠癌的发病率和死亡率上升迅速，预计到2030年，全球结直肠癌患者将新增220万确诊病例以及110万的死亡病例[1]。在最近的研究报告中指出进行结直肠癌早期癌症筛查诊断能显著降低结直肠癌死亡率[2],本实验初步通过二维色谱质谱联用技术及免疫印迹实验来分析RPS14蛋白在结直肠癌组织与癌旁组织的差异，为结直肠癌的筛查和诊断提供帮助。
岳斯琦, 魏丽萍, 何成彦
doaj
, 1986 早期肛管直肠癌治疗效果远比中晚期为优。在尚未找到真正病因和确实的预防措施之前,力争早期发现、早期诊断和早期治疗是现时降低肛管直肠癌死亡率、提高生存率的最有效措施。本文试图通过总结我院外科治疗的早期肛管直肠癌病例资料,分析其临床特点,为医界同道早期发现 ...
万德森
core
Zhongguo shiyan zhenduanxue, 2023 目的 探讨结直肠癌组织和细胞中人整合素α6的表达特点及作用。方法 以人结直肠癌细胞株HT-29、RKO,人永生化结肠上皮细胞系IMCE,以及结直肠癌组织和癌旁正常组织为研究对象。Western blot检测整合素α6在结直肠癌组织和癌细胞中的表达特点；使用整合素α6慢病毒过表达载体转染结直肠癌细胞，进行Transwell细胞迁移和侵袭实验；同时检测整合素α6过表达对结直肠癌细胞E-钙黏蛋白、N-钙黏蛋白、波形蛋白、p-Smad2及Smad2蛋白表达水平。结果 结直肠癌HT-29细胞 ...
邢艳丽 +4 more
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, 2003 目的 探讨结肠镜检查对大肠癌手术的临床作用。方法 分析 116例经病理证实的大肠癌的临床资料、术前结肠镜检查结果和手术治疗情况。结果 结肠镜诊断大肠癌的符合率为 98.3% (114 /116 ) ,其中直肠癌检出率为 5 3.4 % ,直肠癌肛检阳性率 82 .3% ;青年人大肠癌占 3.4 % (4/116 ) ,早期大肠癌占 5 .2 %(6 /116 ) ;BorrmannⅠ型、Ⅱ型、Ⅲ型 ,手术根治率分别为 83.3%、75 .9%、6 0 %。结论 结肠镜检查有助于判断大肠癌的部位、范围 ...
钟燕, 叶震世, 吴艳环
core
Zhongguo shiyan zhenduanxue, 1998 直肠指检与直肠癌的诊断周希欢郭明主张向红直肠指检对直肠癌的诊断极为重要，绝大部分直肠癌可经直肠指检发现病灶。我院自１９８７～１９９７年收治直肠癌６６例，术前主要诊断依据是直肠指检加活组织检查。我们体会，在基层医院直肠指检是诊断直肠癌最重要的检查手段。...
周希欢 +3 more
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