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IL-17基因缺失对小鼠重症哮喘肺部炎性反应的影响

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2014
摘 要: 【目的】 探讨IL-17基因缺失对小鼠重症哮喘肺部炎性反应的影响?【方法】 通过鼻腔给予纯化尘螨提取物对野生型(WT)和IL-17基因敲除(IL-17KO)小鼠建立重症哮喘模型,造模结束后,收集支气管肺泡盥洗液(BALF)及肺组织?通过免疫组化染色观察IL-17在WT小鼠肺组织中的表达情况?检测BALF中细胞数量?分型(包括巨噬细胞?中性粒细胞?淋巴细胞?嗜酸性粒细胞和上皮细胞)?通过ELISA测定BALF中IL-17?IL-4?IL-5?IL-13?TNF-?琢?IFN-γ ...
doaj  

番茄红素对脂多糖诱导巨噬细胞炎症反应的作用及其分子机制

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2011
【目的】 探讨番茄红素对脂多糖(LPS)所诱导的RAW264.7巨噬细胞炎症因子生成的影响及其作用的分子机制【方法】 分别用1510 μmol/L 的番茄红素孵育细胞1 h,再用1 μg/mL LPS 处理细胞不同时间,分别用Griess法和ELISA法检测RAW264.7巨噬细胞培养基中NO及IL-6的含量,用Western-blot检测核因子-κB(NF-κB) p65磷酸化和非磷酸化I-κBα丝裂原活化蛋白激酶(MAPKs)的蛋白表达量【结果】 番茄红素能有效地降低炎性因子NO和IL-6分泌 ...
doaj  

[Exploring the mechanism of IgA vasculitis pathogenesis through the interaction of thrombin and inflammatory factors using urinary proteomics]. [PDF]

open access: yesZhongguo Dang Dai Er Ke Za Zhi
Liu MM   +7 more
europepmc   +1 more source

[Effects of enhancing the expression of aryl hydrocarbon receptor in post-traumatic mice macrophages on the inflammatory cytokine level and bactericidal ability]. [PDF]

open access: yesZhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi, 2023
Kuang TY   +8 more
europepmc   +1 more source

[Mechanism of actions and reflections of Masquelet induced membrane technique in diabetic wound]. [PDF]

open access: yesZhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi
Tao K, Cao T, Shao LC.
europepmc   +1 more source

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