Results 11 to 20 of about 10,209 (164)

Mechanisms of bariatric surgery for weight loss and diabetes remission 减重手术减轻体重和缓解糖尿病的机制

Journal of Diabetes, Volume 15, Issue 9, Page 736-752, September 2023., 2023
Highlights Controversial changes in intestinal hormones after bariatric surgery (BS) were summarized. The changes of signaling proteins involved in insulin resistance and the newly proposed changes in growth differentiation factor 15, exosomes, and extracellular vesicles after BS were elucidated.
Mengsha Yin, Yao Wang, Mingyue Han, Ruishuang Liang, Shanshan Li, Guixia Wang, Xiaokun Gang   +6 more
wiley   +1 more source

A Review of micro RNAs changes in T2DM in animals and humans miRNAs在2型糖尿病人类和动物中的变化

Journal of Diabetes, Volume 15, Issue 8, Page 649-664, August 2023., 2023
Highlights MicroRNAs (miRNAs) are overexpressed in inflammation, insulin resistance, and type 2 diabetes mellitus (T2DM). Many types of miRNAs are changed during the T2DM progression. miRNAs have a potential role as a biomarker in T2DM diagnosis. Abstract Type 2 diabetes mellitus (T2DM) and its associated complications have become a crucial public ...
Mohammad Reza Afsharmanesh, Zeinab Mohammadi, Azad Reza Mansourian, Seyyed Mehdi Jafari   +3 more
wiley   +1 more source

Cytokine transcriptome profiling in acute experimental canine atopic dermatitis skin lesions after IL‐31 inhibition with lokivetmab

Veterinary Dermatology, Volume 34, Issue 4, Page 327-338, August 2023., 2023
Background – The caninised monoclonal antibody lokivetmab (LKV), directed at interleukin (IL)‐31, is very effective at controlling pruritus in most dogs with atopic dermatitis (AD). However, evidence exists that IL‐31 is not required for the induction of acute allergic skin inflammation, which might explain why this treatment is less efficacious in ...
Chie Tamamoto‐Mochizuki, Natalie Crawford, Jordan M. Eder, Andrea J. Gonzales, Thierry Olivry   +4 more
wiley   +1 more source

HLA‐DR3 mediated CD4 T cell response against GAD65 in type 1 diabetes patients HLA‐DR3介导的CD4 T细胞对1型糖尿病患者GAD65的应答

Journal of Diabetes, Volume 15, Issue 7, Page 607-621, July 2023., 2023
Highlights The CD4 T cells of type 1 diabetes (T1D) patients particularly having HLA‐DRB1*03‐DQA1*05‐DQB1*02 haplotype are reactive against a particular region of the glutamic acid decarboxylase (GAD65) protein. GAD65 peptides encompassing 288–308 amino acid positions (peptide pool 2) may be favored by the HLA‐DR3 molecule for presentation to CD4 T ...
Neihenuo Chuzho, Neetu Mishra, Nikhil Tandon, Uma Kanga, Gunja Mishra, Akanksha Sharma, Narinder K. Mehra, Neeraj Kumar   +7 more
wiley   +1 more source

Electroacupuncture reduces blood glucose by regulating intestinal flora in type 2 diabetic mice 电针通过调节2型糖尿病小鼠肠道菌群降低血糖

Journal of Diabetes, Volume 14, Issue 10, Page 695-710, October 2022., 2022
Highlights Electroacupuncture (EA) regulates the intestinal flora by promoting intestinal motility. EA regulated the intestinal flora to reduce the level of systemic inflammation. EA lowering the blood glucose by the IKKβ/NF‐κB‐JNK‐IRS‐1‐AKT signal pathway.
Jing An, Lingli Wang, Shuangning Song, Lugao Tian, Qingqing Liu, Minhui Mei, Wenhua Li, Shi Liu   +7 more
wiley   +1 more source

Local treatment for canine anal sacculitis: A retrospective study of 33 dogs

Veterinary Dermatology, Volume 33, Issue 5, Page 426-434, October 2022., 2022
Abstract Background Little information has been published regarding treatment of canine anal sacculitis (AS). Objectives Primary objective: determine the outcomes of AS local treatment at the referral dermatology service of the authors' institution. Secondary objective: determine signalment, body condition score (BCS), stool quality and comorbidities ...
Annette Lundberg, Sandra N. Koch, Sheila M.F. Torres   +2 more
wiley   +1 more source

Alterations in epidermal function in type 2 diabetes: Implications for the management of this disease 2型糖尿病患者表皮功能的变化及其对治疗的意义

Journal of Diabetes, Volume 14, Issue 9, Page 586-595, September 2022., 2022
Highlights Individuals with type 2 diabetes display epidermal dysfunction. Epidermal dysfunction can provoke cutaneous and extracutaneous inflammation. Because of the pathogenic role of inflammation in type 2 diabetes, improvements in epidermal functions could benefit type 2 diabetes.
Mao‐Qiang Man, Joan S. Wakefield, Theodora M. Mauro, Peter M. Elias   +3 more
wiley   +1 more source

Effect of type 2 diabetes on A disintegrin and metalloprotease 10 2型糖尿病对解整合素金属蛋白酶10表达的影响

Journal of Diabetes, Volume 14, Issue 6, Page 394-400, June 2022., 2022
Highlights a disintegrin and metalloprotease 10 (ADAM10), a sheddase responsible for the cleavage of a variety of cell surface molecules, has been implicated in the pathogenesis of Alzheimer disease, atherosclerosis, and inflammatory and neoplastic disorders, and systemic ADAM10 concentration may potentially be used as a prognostic biomarker. Our study
Sum Lam, Sammy Wing‐Ming Shiu, Ying Wong, Kathryn Choon‐Beng Tan   +3 more
wiley   +1 more source

Targeting the PI3K/Akt signaling pathway in pancreatic β‐cells to enhance their survival and function: An emerging therapeutic strategy for type 1 diabetes 一种新兴的1型糖尿病治疗策略:靶向胰腺β细胞中的PI3K/Akt信号通路以增强其存活和功能

Journal of Diabetes, Volume 14, Issue 4, Page 247-260, April 2022., 2022
Highlights Phosphoinositide 3‐kinase (PI3K)/Akt signaling is an emerging promising therapeutic target for diabetes. Modulation of the PI3K/Akt signaling pathway, via protein and peptide‐based biologics, parasite‐derived molecules, plant extracts, or through microRNA interactions, will regulate the processes that determine the function of β‐cells and ...
Inah Camaya, Sheila Donnelly, Bronwyn O'Brien   +2 more
wiley   +1 more source

Altered plasma cytokines in dogs with atopic dermatitis

Veterinary Dermatology, Volume 33, Issue 2, Page 131-e38, April 2022., 2022
Background – Canine (Canis lupus familiaris) atopic dermatitis (AD) shares similar clinical signs to human AD. The abnormal immune response of AD is orchestrated by T lymphocytes, and may include variable involvement of cytokines, Regulatory T (Treg) cells, eosinophils, mast cells and other immune components.
Hamutal Mazrier, Linda J. Vogelnest, Rosanne M. Taylor, Peter Williamson   +3 more
wiley   +1 more source