Results 21 to 30 of about 10,209 (164)
Neuropsychopharmacology Reports, Volume 45, Issue 4, December 2025.This study reports the development and linguistic validation of the Japanese version of the Chronic Pain Attribution Scale. The tool captures culturally nuanced beliefs about chronic pain causes and provides a foundation for research on treatment responses in Japanese‐speaking populations.
Keiko Yamada +8 more
wiley +1 more source
Updated insights into the molecular pathogenesis of canine atopic dermatitis
Veterinary Dermatology, Volume 36, Issue 4, Page 375-384, August 2025.Abstract Atopic dermatitis (AD) is a common and chronic inflammatory skin disease with frequent relapses. The genomics revolution has greatly contributed and revolutionised our knowledge of human AD; understanding the molecular skin fingerprint of AD and associated pathogenic immune pathways has led to preclinical assessments of several novel ...
Frane Banovic
wiley +1 more source
The effects of unilateral corneal nerve disconnection on bilateral corneal epithelial barrier function [PDF]
, 2016 目的：正常的角膜上皮屏障具有维持眼表内环境稳态，保护角膜免受外来侵袭的功能。目前已知眼外伤、炎症、代谢紊乱、局部用药等因素会引起角膜上皮表层细胞连接蛋白分布及表达量改变，进而导致上皮屏障功能破坏。屏障功能障碍是多种眼表疾病发生、发展的病理学基础。角膜神经也被证实与角膜上皮之间存在着相互沟通和联系。本研究拟探讨切断单侧角膜神经后，双侧上皮屏障功能的变化，并揭示出现这种变化的可能作用机制。 方法：将正常的wistar大鼠随机分成3组即：空白对照组，环钻处理组，划“×”组，每组30只。分组后 ...
刘凡菲
core
Veterinary Dermatology, Volume 36, Issue 4, Page 443-452, August 2025.Background – Allergen immunotherapy is used as aetiological treatment for canine atopic dermatitis (cAD). Objective – To assess the anti‐inflammatory agent‐sparing effect over 1 year of immunotherapy using pullulan‐conjugated recombinant Der f 2 (rDf2‐P). Conclusions and Clinical Relevance – Der f 2‐P immunotherapy can lead to a rapid reduction in anti‐
Masahiko Nagata +7 more
wiley +1 more source
Searching for the novel mediators of LPS/TLR4/MyD88 signalling [PDF]
, 2016 TRAF6蛋白在LPS/TLR4介导的MyD88依赖型的信号通路中起核心的作用，目前已有报道TAK1作为TRAF6的下游底物，与TAB1/TAB2/TAB3形成复合物，进而激活NF-kB、MAPK信号通路，促进细胞炎症因子的释放。但是，随后有实验室利用最新基因敲除技术在小鼠或细胞水平敲掉TAK1、TAB1、TAB2，MEKK3等基因后，用LPS刺激诱导MyD88依赖型信号通路，发现对NF-kB和MAPK信号通路均没有影响。因此，在LPS诱导的LPS/TLR4/MyD88信号通路中 ...
李婉芸
core
Veterinary Dermatology, Volume 36, Issue 4, Page 401-411, August 2025.Background – Itch is a common symptom in skin disorders. While the neural pathways of itch transmission from the skin to the brain are well‐understood in rodents, the same pathways in dogs remain unclear. The knowledge gap hinders the development of effective treatments for canine itch‐related disorders.
Chie Tamamoto‐Mochizuki +1 more
wiley +1 more source
寻常型银屑病患者血清Lipocalin-2检测水平及与疾病活动性、炎症标志物、代谢指标的关系
Zhongguo shiyan zhenduanxue, 2021 寻常型银屑病是一种具有特征性皮损的慢性炎症性皮肤病,易复发,其病理机制尚不完全清楚,多认为T淋巴细胞介导的免疫炎症反应是其发病的重要因素[1]。研究表明,寻常型银屑病患者外周血T淋巴细胞表现为增殖活性增强,活化的T淋巴细胞通过细胞表面粘附因子浸润真皮,真皮层浸润的T淋巴细胞通过释放干扰素,诱导表皮细胞合成肿瘤坏死因子α（TNF-α）及白细胞介素（IL）等细胞因子,导致表皮中性粒细胞浸润,而引起皮肤炎症[2]。
运蓓蕾, 林伟, 刘悦
doaj
N-Oleoylethanolamine attenuates cytokines and adhesion molecules production in TNF-α-induced human umbilical vein endothelial cells by activating PPAR-α and CB2 [PDF]
, 2015 研究背景：动脉粥样硬化（Atherosclerosis,As）是由多个因素造成的开始于动脉内膜的一种疾病，现如今As的发病率和致死率逐渐升高，并且发病年龄年轻化。大量的流行病学调查和实验研究证明,高血脂、高血压、吸烟、糖尿病等都是与As发生相关的危险因素，但关于As发生的机制一直众说纷纭，直到1999年，ROSS等提出“As是一种慢性炎症性疾病”的观点，给As的研究带来了一个全新的方向与思路。本论文的研究就是基于这个观点，从炎症反应的角度去探索一种新的、副作用小的抗动脉粥样硬化药物。油酰乙醇胺（N ...
许旭东
core
Veterinary Dermatology, Volume 36, Issue 3, Page 291-301, June 2025.Background – Canine interdigital furunculosis (CIF) is a complex, relapsing inflammatory condition, typically complicated by deep bacterial infections requiring prolonged systemic antibiotics. Hypothesis/Objectives – This split‐body study, where dogs acted as their own control, evaluated whether the adjunctive use of fluorescent light energy (FLE ...
A. Lange +12 more
wiley +1 more source
慢性房颤患者心房组织中SOCS-1和IL-23水平的动态变化与房颤的关系
Zhongguo shiyan zhenduanxue, 2017 近年来,有关炎症与炎症因子在房颤（AF）发病过程中的作用越来越引起人们重视。白细胞介素-23（IL-23）主要是由活化的单核巨噬细胞及树突状细胞分泌的炎症细胞因子,与许多炎症疾病有关,有学者发现它参与了AF的病理过程[1]。细胞因子信号转导负调控因子-1（SOCS-1）是由炎症因子激活JAK/STAT通路产生的一种炎症因子,它反过来通过抑制该通路对炎症反应有负调控作用,本文对慢性AF患者心房组织中SOCS-1和IL ...
王朋 +5 more
doaj