Results 81 to 90 of about 2,214 (157)
Mechanism of Huanglian Wendan Decoction in treatment of pelvic inflammatory disease based on network pharmacology and molecular docking technology [PDF]
Objective To explore the mechanism of Huanglian Wendan Decoction in the treatment of pelvic inflammatory disease using network pharmacology and molecular docking technology.
GAO Xiuan +4 more
core +1 more source
Zhongguo shiyan zhenduanxue, 2015 乳腺癌的发生发展为多基因参与和多阶段协同作用的结果[1]。远处转移是导致乳腺癌患者死亡的主要因素[2]。提高乳腺癌微转移的检出率,对判断患者的预后和合理选择治疗方案,提高患者生存率均有重要意义。在乳腺癌患者的骨髓和外周血液中评价游离的肿瘤细胞已经成为一个肿瘤转移的研究焦点。在1869年,Ashworth[3]提出了循环肿瘤细胞的概念。循环肿瘤细胞是指自发或因诊疗操作进入外周血循环的肿瘤细胞。在1889年,Paget[4 ...
王丽娟, 张研, 吕昭宝
doaj
Application of pyroptosis score in the treatment and prognosis evaluation of gastric cancer. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2023 Li L, Liao A.
europepmc +1 more source
Progress in epigenetic modification of ferroptosis involved in chronic obstructive pulmonary disease [PDF]
Ferroptosis is a special type of programmed cell death, which is different from autophagy, apoptosis and other modes of death, and characterized by mitochondrial shrinkage, membrane density increase and ridge reduction.
CAI Xiaoyu +3 more
core +1 more source
Zhongguo shiyan zhenduanxue, 2019 2型糖尿病(T2DM)是指胰岛素抵抗为主伴胰岛素分泌不足,或胰岛素分泌不足伴有或不伴有胰岛素抵抗所致的糖尿病[1]。糖尿病患者长期高血糖引起多种并发症且症状难以逆转,导致失明、截肢、动脉硬化、认知能力下降及过早死亡,患有糖尿病的个体被诊断为抑郁、焦虑和饮食失调的风险明显增加。不仅显著增加了医疗成本,对患者的生活质量也造成严重的危害。近年来,我国2型糖尿病的发病率逐年上升,发病年龄有明显的年轻化趋势[2]。
申有霞, 毋晶, 赵岩
doaj
Study on the action mechanism of lncRNA MIAT/miR-384-5p in rats with acute myocardial infarction [PDF]
Objective To investigate the role and molecular mechanism of lncRNA MIAT inhibition in acute myocardial infarction (AMI) in rats. Methods Sixty male Sprague-Dawley (SD) rats were randomly divided into sham, AMI, AMI+si-NC, AMI+si-MIAT, AMI+si-MIAT+miR-NC
CHEN Huibin, JIAN Jie, LI Can
core +1 more source
Thapsigargin对人晶状体上皮细胞系SRA01／04增殖抑制的作用机制
Zhongshan Daxue xuebao. Yixue kexue ban, 2007 【目的】研究thapsigargin（TG）对体外培养的人品状体上皮细胞系SRA01／04增殖的影响，并探讨其分子机制。【方法】不同浓度TG处理SRA01／04细胞72h，噻唑蓝比色法（MTT）检测细胞增殖；流式细胞仪（PI法）检测细胞周期改变；透射电镜观察细胞超微结构变化；TUNEL法检测细胞核中DNA的断裂情况；激光共焦显微镜和流式细胞仪检测Caspase3活性亚单位（17／19ku）的表达及阳性细胞表达率。【结果】MTT法测得TG为0．325～5μmol／L时，细胞增殖抑制率变化显著 ...
姬红培, 吴明星, 彭瑞萍
doaj
Zhongshan Daxue xuebao. Yixue kexue ban肺移植（LTx），是治疗终末期肺疾病（ESLD）唯一有效的根治性治疗手段，适用于药物和其他手术治疗无效的晚期肺病患者，可显著改善患者预后。但LTx仍面临诸多挑战，如缺血再灌注损伤（IRI）、长期生存率低等。改善肺IRI对移植术后肺功能的恢复和患者预后有重要意义。肺IRI是指肺组织经历血流中断（缺血）后恢复供血（再灌注）时，反而加重的组织损伤和炎症反应。IRI是导致原发性移植物功能障碍（PGD）的重要病理生理基础，其损伤机制复杂多样，涉及多种细胞死亡的激活。程序性细胞死亡（PCD）是细胞受基因调控发生的 ...
虞燕青, 孙煦勇
doaj
Transcriptome Analysis of Effect of Cordyceps militaris Aqueous Extract in Human Gastric Cancer Cell BGC-823 on Different RCD Pathways [PDF]
Objective: The main regulated cell death (RCD) signaling pathway of Cordyceps militaris (XG) water extract that affects the growth activity of the human gastric cancer cell line BGC-823 was analyzed and predicted using transcriptome sequencing technology.
Fangxu XU +5 more
core +1 more source
Linchuang shenzangbing zazhi, 2014 随着人们生活方式的改变,糖尿病(diabetes mellitus,DM)的发病率逐年升高,糖尿病可以引起多种并发症,导致患者的死亡。世界卫生组织指出,如果不采取重大措施,2025年全世界将出现3.8亿例糖尿病患者;我国成人中约有1.139亿糖尿病患者及约5亿糖尿病前期人群,居世界第一位[1],而且数量日益增多。因此,DM已经成为当前威胁人类健康的主要疾病,引起全球瞩目的焦点。DM的并发症可以波及不同脏器,很大比例的患者会有肾脏的病变,DM导致肾脏病变一直是肾病研究的热点。
朱琳
doaj