nIL-33介导的巨噬细胞极化在口腔鳞状细胞癌中的作用及机制研究进展
口腔鳞状细胞癌(OSCC)是世界范围内最常见的头颈部恶性肿瘤,OSCC的发生与口腔黏膜的癌前病变密切相关。巨噬细胞是黏膜免疫的重要参与者,通过调控不同表型的极化状态促进OSCC进展。核白细胞介素-33(nIL-33)通过调控细胞线粒体代谢重塑巨噬细胞极化。本文系统综述巨噬细胞与口腔鳞癌进展的关系,从细胞核-线粒体调控极化表型角度阐明巨噬细胞极化自我调控机制,以期为靶向巨噬细胞抗OSCC治疗提供思路和参考。
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