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Effect of Tropomyosin of Macrobrachium nipponense on Mouse Macrophage Polarization Based on Transcriptomic Analysis(基于转录组学分析日本沼虾原肌球蛋白对小鼠巨噬细胞极化的影响) [PDF]

Shipin kexue jishu xuebao, 2022
To study the effect of tropomyosin of Macrobrachium nipponense on macrophage polarization, the differential analysis of gene expression during tropomyosin-induced macrophage polarization was analyzed by transcriptomic analysis.
HU Xin(胡昕), LUO Yeqing(骆叶晴), SUN Yaobin(孙耀斌), CHEN Hongbing(陈红兵), XIE Yanhai(谢彦海)   +4 more
doaj   +1 more source

Use of carrion fly iDNA metabarcoding to monitor invasive and native mammals

Conservation Biology, Volume 37, Issue 5, October 2023., 2023
Abstract Severely fragmented habitats increase the risk of extirpation of native mammal populations through isolation, increased edge effects, and predation. Therefore, monitoring the movement of mammal populations through anthropogenically altered landscapes can inform conservation. We used metabarcoding of invertebrate‐derived DNA (iDNA) from carrion
Kristen Fernandes, Philip W. Bateman, Benjamin J. Saunders, Michael Bunce, Kristine Bohmann, Paul Nevill   +5 more
wiley   +1 more source

Autophagy in the retinal neurovascular unit: New perspectives into diabetic retinopathy 视网膜神经血管单元自噬:糖尿病视网膜病变的新视角

Journal of Diabetes, Volume 15, Issue 5, Page 382-396, May 2023., 2023
HighlightsAutophagy is closely related to retinal neurovascular units in diabetes retinopathy. Different cells participate in the occurrence and development of diseases through autophagy, and targeted autophagy may be a new direction of treatment in the future. Emphasized the close relationship between diabetic retinopathy (DR) and autophagy Summarized
Xiongyi Yang, Zexin Huang, Mei Xu, Yanxia Chen, Mingzhe Cao, Guoguo Yi, Min Fu   +6 more
wiley   +1 more source

Mechanisms of diabetic foot ulceration: A review 糖尿病足溃疡发生机制综述

Journal of Diabetes, Volume 15, Issue 4, Page 299-312, April 2023., 2023
Highlights With the increase in the elderly population, diabetic foot ulcers (DFUs) severely affect human health and societies worldwide. They will pose significant medical, social, and socioeconomic challenges. Reviewing the existing studies on the pathogenesis of DFUs, most of them focus on clinical nursing and treatment.
Haibo Deng, Binghui Li, Qian Shen, Chenchen Zhang, Liwen Kuang, Ran Chen, SiYuan Wang, ZhiQiang Ma, Gongchi Li   +8 more
wiley   +1 more source

Electroacupuncture reduces blood glucose by regulating intestinal flora in type 2 diabetic mice 电针通过调节2型糖尿病小鼠肠道菌群降低血糖

Journal of Diabetes, Volume 14, Issue 10, Page 695-710, October 2022., 2022
Highlights Electroacupuncture (EA) regulates the intestinal flora by promoting intestinal motility. EA regulated the intestinal flora to reduce the level of systemic inflammation. EA lowering the blood glucose by the IKKβ/NF‐κB‐JNK‐IRS‐1‐AKT signal pathway.
Jing An, Lingli Wang, Shuangning Song, Lugao Tian, Qingqing Liu, Minhui Mei, Wenhua Li, Shi Liu   +7 more
wiley   +1 more source

Glomerular cell cross talk in diabetic kidney diseases 糖尿病肾病中肾小球细胞间的相互作用

Journal of Diabetes, Volume 14, Issue 8, Page 514-523, August 2022., 2022
Highlights Glomerular cell cross talk is essential for maintaining the glomerular filtration barrier. In‐depth exploration of intraglomerular signaling pathway changes during diabetic kidney disease may help discover new therapeutic targets. Abstract Diabetic kidney disease (DKD) is a severe microvascular complication of diabetes mellitus.
Ruixue Dong, Youhua Xu
wiley   +1 more source

Targeting the PI3K/Akt signaling pathway in pancreatic β‐cells to enhance their survival and function: An emerging therapeutic strategy for type 1 diabetes 一种新兴的1型糖尿病治疗策略:靶向胰腺β细胞中的PI3K/Akt信号通路以增强其存活和功能

Journal of Diabetes, Volume 14, Issue 4, Page 247-260, April 2022., 2022
Highlights Phosphoinositide 3‐kinase (PI3K)/Akt signaling is an emerging promising therapeutic target for diabetes. Modulation of the PI3K/Akt signaling pathway, via protein and peptide‐based biologics, parasite‐derived molecules, plant extracts, or through microRNA interactions, will regulate the processes that determine the function of β‐cells and ...
Inah Camaya, Sheila Donnelly, Bronwyn O'Brien   +2 more
wiley   +1 more source

The effect of short‐term intensive insulin therapy on inflammatory cytokines in patients with newly diagnosed type 2 diabetes 短期胰岛素强化治疗对新诊断的2型糖尿病患者炎性细胞因子的影响

Journal of Diabetes, Volume 14, Issue 3, Page 192-204, March 2022., 2022
Highlights Many proinflammatory cytokines could be decreased after 1 week of intensive insulin therapy using continuous subcutaneous insulin infusion (CSII). This was the first report showing that the cytokines of interleukin‐6 receptor (IL‐6R), tissue inhibitor of metalloproteinase‐2 (TIMP‐2), platelet‐derived growth factor type BB (PDGF‐BB), and ...
Junyu He, Peiji Dai, Liyi Liu, Yanqing Yang, Xibo Liu, Yanbing Li, Zhihong Liao   +6 more
wiley   +1 more source

Relationships between type 2 diabetes, cell dysfunction, and redox signaling: A meta‐analysis of single‐cell gene expression of human pancreatic α‐ and β‐cells 2型糖尿病、细胞功能障碍和氧化还原信号的关系:人胰腺α‐和β‐细胞单细胞基因表达的meta分析

Journal of Diabetes, Volume 14, Issue 1, Page 34-51, January 2022., 2022
Highlights Meta‐analysis of α‐ and β‐cell transcriptomes reveals modified energy metabolism, immune response, autophagy, and cellular stress pathways in cells from type 2 diabetes mellitus. The proportion of immature and senescent β‐cells is increased in islets from type 2 diabetes mellitus.
Emily Sara Marques, Emily Formato, Wenle Liang, Emily Leonard, Alicia R. Timme‐Laragy   +4 more
wiley   +1 more source

Wnt/β-catenin信号通路在结直肠癌中的研究进展

Zhongguo shiyan zhenduanxue, 2021
结直肠癌(CRC)是目前消化系统常见的恶性肿瘤之一,近年来结直肠癌的发病率逐年上升,结直肠癌的高发病率、死亡率严重影响着人类的健康[1]。而与结直肠癌相关的细胞信号转导通路有多条,如Wnt/β-catenin信号通路、TGF-β/Smads信号通路、Hedgehog信号通路等,其中Wnt通路的异常激活是导致结直肠癌发生、发展的主要原因。研究显示,在结直肠癌的发生、发展、转移、复发及相关治疗的过程中,Wnt/β-catenin信号通路的异常激活起到了重要作用,大部分结直肠癌存在Wnt/β ...
焉秀章, 夏文龙, 夏俊伟, 张海山   +3 more
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