Results 21 to 30 of about 13,739 (168)
Study of the negative feedback loop of OVOL2 on WNT signaling in colorectal cancer progression [PDF]
, 2015 背景与目的：激活的Wnt信号通路能够促进多种癌细胞的侵袭，而在结直肠癌（CRC）的进展中WNT信号通路参与与否及其参与的机制均知之甚少。OVOL2是Ovo家族成员之一，是由WNT信号通路调控的，具有保守锌指结构的转录因子。该课题主要研究了OVOL2在小鼠和人类肠道肿瘤中的表达和功能，及其协同WNT信号通路在肠道肿瘤进展中的作用。 方法：利用免疫印迹法和实时荧光定量PCR，检测七种结直肠癌细胞中OVOL2蛋白的表达及其mRNA的水平；利用免疫组织化学（IHC）方法，检测OVOL2在结直肠癌组织芯片中的表达；
叶国栋
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SWEET1‐mediated glucose transport is crucial for energy availability in Arabidopsis
New Phytologist, Volume 249, Issue 4, Page 1816-1830, February 2026.Summary The stress‐responsive hormone abscisic acid (ABA) is known for its inhibitory effects on various physiological processes, including seed germination, often resulting in energy deprivation. Interestingly, ABA‐induced germination inhibition can be alleviated by exogenous glucose (Glc), mimicking a functional interplay between ABA and sugar ...
Xueyi Xue +3 more
wiley +1 more source
The Role of PERK-eIF2α-Yap Signaling in the Development of Hepatocellular Carcinoma [PDF]
, 2016 已有研究证实，Hippo信号通路失活会造成肝脏肿大和肿瘤发生，其中Yap的活性在Mst1/2双敲除小鼠肝细胞癌的发生中非常重要；内质网稳态的异常调节也在多种癌症中出现，但未折叠蛋白反应(UPR)在组织稳态中的调节作用还不清楚。我们之前的研究工作发现，在Mst1/2双敲除的小鼠肝脏中UPR被明显激活；进一步研究发现，UPR中的PERK支路能够调控Yap的转录。因此，我们想探究Hippo信号通路和UPR信号通路在肝癌发生发展中的关系。 我们认为Mst1/2双敲除小鼠肝脏中存在的慢性内质网应激 ...
江铭婷
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International Journal of Urban and Regional Research, Volume 50, Issue 1, Page 191-220, January 2026.Abstract Henry George advocated for capturing land value increases for public ends. The active approach of public authorities organizing and financing land development can help capture higher land value increases, as Hartman and Spit indicate. However, this approach hardly happens in developing countries, where the coalition of private developers and ...
Nannan Xu
wiley +1 more source
浙江大学学报. 医学版糖尿病肾病是常见的糖尿病微血管并发症，也是糖尿病患者死亡的主要原因之一。铁死亡是一种铁依赖性调节性细胞死亡，其在糖尿病肾病的发生发展中具有一定作用。腺苷一磷酸活化的蛋白质激酶（AMPK）介导的铁死亡相关信号通路可以延缓糖尿病肾病的进程，但AMPK信号过度激活可能会诱导细胞发生自噬性死亡；激活核转录因子红系2相关因子（Nrf）2和血红素加氧酶（HO）-1介导的信号通路能够抑制细胞铁死亡并改善糖尿病肾病，但HO-1在铁死亡中的调节作用是双向的，激活HIF-1α/HO-1信号通路可能导致细胞内铁过载 ...
刘 攀, 张 正东, 陈 秋
doaj +1 more source
The regulation of TAK1 function by caspase [PDF]
, 2016 TAK1是NF-κB信号通路中的核心激酶蛋白。它参与先天性免疫、炎症反应、肿瘤形成等众多信号通路，其中在炎症反应和天然免疫通路中被深入研究。在TAK1激酶被激活后，它将磷酸化IKK和MAP2K等激酶，进而活化NF-κB和MAPK，从而使细胞的炎症因子表达来产生炎症反应。通过敲除小鼠的TAK1发现，小鼠细胞中与炎症和先天性免疫相关的效应因子如NF-κB、JNK和P38的激活均受到抑制，表明TAK1在相关信号通路的调控过程中处于核心地位。 细胞凋亡是一种细胞程序性坏死的方式，当细胞受到凋亡刺激后 ...
濮云飞
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Veterinary Dermatology, Volume 36, Issue 4, Page 401-411, August 2025.Background – Itch is a common symptom in skin disorders. While the neural pathways of itch transmission from the skin to the brain are well‐understood in rodents, the same pathways in dogs remain unclear. The knowledge gap hinders the development of effective treatments for canine itch‐related disorders.
Chie Tamamoto‐Mochizuki +1 more
wiley +1 more source
Yap Regulates ATF6-Mediated Unfolded Protein Response [PDF]
, 2015 Hippo信号通路最早在果蝇里发现，是在进化上高度保守的一条激酶级联的通路，当Hippo通路的缺失会造其下游调控因子Yap或Taz的激活，促进细胞增殖，抑制细胞凋亡，从而导致器官增大和肿瘤产生。此外，大量文献阐述了内质网压力和肿瘤产生具有相关性。本实验室研究表明，Hippo通路的缺失或Yap蛋白的激活会引起内质网应激信号通路的激活和内质网的增大，并通过内质网应激反应导致肝脏器官增大和肿瘤生成。 当Hippo激酶，在高等动物的同源物为Mst1和Mst2激酶的缺失或Yap激活时 ...
蔡亚波
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How Many Floods Have Occurred in China in the Past Decade? A Perspective From Social Media
Earth's Future, Volume 13, Issue 4, April 2025.Abstract Global climate change has led to frequent and widespread flood disasters in China. Traditional flood disaster investigations mainly focus on major flood events, and small‐scale flood events are often overlooked. This study utilized the Sina Weibo social media platform to detect flood events in 370 cities in China from 2012 to 2023.
D. Shen +5 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2017 急性呼吸窘迫综合征（ARDS）是一种进行性缺氧性呼吸衰竭的危重症疾病。目前ARDS的发病机制在很大程度上仍然不明,但越来越多的证据表明多种信号通路及相关的蛋白可调节急性肺损伤的炎症反应。参与ARDS潜在的信号通路可能包括PI3K/Akt/mTOR信号通路、p38MAPK和ERK信号通路、TLR信号通路、STAT3信号通路、Wnt/
郭龙, 张春媚, 高勇, 赵忠岩
doaj