Results 21 to 30 of about 11,466 (118)
Network of VAMP714‐dependent interactions during salt stress. Summary Plant responses to salt stress include an altered root architecture mediated by ion imbalances, reactive oxygen species (ROS) accumulation, and altered hormonal responses. Auxin is implicated in these processes.
Jialei Sun +3 more
wiley +1 more source
ABSTRACT Bone restoration is often hindered by the spatiotemporal dysregulation of immune and regenerative signals. Conventional bio‐inert implants, providing only passive support, fail to modulate this microenvironment, leading to infections and poor healing.
Zhizhong Sun +8 more
wiley +1 more source
ABSTRACT Lung cancer is one of the most common and deadly malignancies worldwide. Although immune checkpoint inhibitors, including PD‐1/PD‐L1 blockers, have benefited a subset of patients, response rates remain limited, and recurrence is frequent because of the immunosuppressive tumor microenvironment (TME), characterized by hypoxia and dysregulated ...
Yi Ma +6 more
wiley +1 more source
ABSTRACT The poor soft tissue integration around titanium implants creates a microgap that serves as a pathway for pathogen invasion, resulting in infection, inflammation, and the progression of peri‐implantitis. As the implant’s transmucosal component, the abutment determines the degree of peri‐implant soft tissue attachment.
Xuan Li +7 more
wiley +1 more source
ABSTRACT The efficacy of immunotherapy in triple‐negative breast cancer (TNBC) is often limited, whereas the immunotherapeutic potential of pyroptosis is frequently undermined by a compensatory surge in mitophagy. To address this challenge, this study developed a reactive oxygen species (ROS)‐responsive and mitochondria‐targeted nanomicelle (POM@CTT ...
Qingqing Dou +6 more
wiley +1 more source
ABSTRACT This study introduces novel nonequiatomic TiZrCoCrMoCux (x = 0, 5, 10; at%) medium‐entropy alloys (MEAx) tailored for orthopedic implants, synergistically combining the biocompatibility of Ti‐based alloys, the wear resistance of CoCrMo alloys, and the antibacterial/osteogenic attributes of Cu. The alloy's microstructure, mechanical properties,
Hang Yu +9 more
wiley +1 more source
急性呼吸窘迫综合征(ARDS)是一种进行性缺氧性呼吸衰竭的危重症疾病。目前ARDS的发病机制在很大程度上仍然不明,但越来越多的证据表明多种信号通路及相关的蛋白可调节急性肺损伤的炎症反应。参与ARDS潜在的信号通路可能包括PI3K/Akt/mTOR信号通路、p38MAPK和ERK信号通路、TLR信号通路、STAT3信号通路、Wnt/
郭龙, 张春媚, 高勇, 赵忠岩
doaj
糖尿病肾病是常见的糖尿病微血管并发症,也是糖尿病患者死亡的主要原因之一。铁死亡是一种铁依赖性调节性细胞死亡,其在糖尿病肾病的发生发展中具有一定作用。腺苷一磷酸活化的蛋白质激酶(AMPK)介导的铁死亡相关信号通路可以延缓糖尿病肾病的进程,但AMPK信号过度激活可能会诱导细胞发生自噬性死亡;激活核转录因子红系2相关因子(Nrf)2和血红素加氧酶(HO)-1介导的信号通路能够抑制细胞铁死亡并改善糖尿病肾病,但HO-1在铁死亡中的调节作用是双向的,激活HIF-1α/HO-1信号通路可能导致细胞内铁过载 ...
刘 攀, 张 正东, 陈 秋
doaj +1 more source
ABSTRACT Interlingual translation, as defined by Roman Jakobson, refers to the transfer of meaning between languages. However, this concept has often been conflated with linguistic shifts between distinct cultures and nation‐states. To challenge this misconception, I propose the concept of self‐consumption translation (SCT), a subfield of interlingual ...
Bilin (Belen) Liu
wiley +1 more source
针对智能交通系统基础理论之一的路口交通信号控制问题,以典型"+"字路口为例,提出了更能概括路口多入多出情况的交通信号矩阵控制模型,该模型能反映交通信号的各种实际控制策略,模型参量具有明确的实际意义.在此模型基础上,分析了路口车辆流入量与流出量、车辆流出量与交通信号控制的关系,在避免路口发生碰撞的前提下,得到了路口的优化控制方案.
刘怡光, 游志胜, 曹丽萍
doaj

